Earlier quoted context omitted.
Metformin is miserable. Why go on that over a GLP-1?
Because its OTC, xtremelly safe and and it works. What issues do u have with it.
It's not OTC in the US.
Semaglutide linked to lower predicted dementia risk
421–430 of 430 posts
Re: Semaglutide linked to lower predicted dementia risk
#422Earlier quoted context omitted.
I have a very similar situation: on it for about a year, 220lbs to 180 at age ~40. Also very active: weight lifting / biking / swimming and - the sport that made me realize I needed to loose weight - rock climbing. I've always been very outdoorsy-adventurous, and climbing/mountaineering is the natural sort of "end game" for this lifestyle. My weight never really got in the way of anything else in my life (maybe my se…
Do you think the lower energy levels also affect your cognition?
Not really, or I haven't noticed anything. Even from a motivational perspective, which I've heard can be a problem on semaglutide more so than cognition, I haven't noticed anything. It seems to be a pure physical energy thing ("the spirit is willing, but the body...").
However, I started a new position at a startup which is very heavily invested in agentic development, to the point where I basically just drive claude and codex all day long, and haven't written a single line of code for work in 9 months, and that may be causing some cognitive decline...
Re: Semaglutide linked to lower predicted dementia risk
#423Earlier quoted context omitted.
It’s both. There is a very vocal contingent who insist that obesity is not unhealthy.
There are people who claim that, yes, but that’s not broadly what the movement is about. Every philosophy or movement has outliers that misinterpret and act outside of the bounds of that movement and we understand that those outliers don’t represent the group; yet people always look to those outliers with the fat acceptance movement — the fat acceptance movement is not given the benefit of the doubt like others are.…
You are doubtless correct that there is bias. (Literally your stated purpose of the movement is to counter this bias.) But with that said, these voices may be outliers, but they are by far the loudest. I’ve seen people claim that “obese” is a slur. I’ve heard more people claim that health is unrelated to weight more than I’ve heard people say that fat people deserve good healthcare.
From my vantage point the movement has largely been co-opted by extremists who want to pretend that obesity is not a health problem.
Re: Semaglutide linked to lower predicted dementia risk
#424Earlier quoted context omitted.
Because its OTC, xtremelly safe and and it works. What issues do u have with it.
It has negative side effects in many people: https://www.mayoclinic.org/drugs-supplements/metformin-oral-...
GLP-1 also does and it also wasn't used by millions of people in last 50 years.
Re: Semaglutide linked to lower predicted dementia risk
#425Earlier quoted context omitted.
Haven't measured it exactly, but haven't noticed a reduction in my lifts either. I do have a home gym, throttled my marathon training and try my best with Skyr and protein shakes though.
Any idea if a pill form will be available in the future?
Pill form is only available for regular GLP-1, not the double (tirzepatide) and triple agonist (retatrutide).
Re: Semaglutide linked to lower predicted dementia risk
#426Earlier quoted context omitted.
That's a common and very acceptable concern and there's not great answers for it. Mostly a place will do multi-vail testing for purity, sterility, endotoxin and heavy metals. The idea is that the sample is sufficient to show safety. Many are rightfully dubious of this but still thousand and thousands of people taking it.
I'm using reta myself, but honestly it's because sema/tirz isn't allowed for me either. If you have medical tirz available, you should have some serious reasons to jump into the unregulated shark tank.
A lot of us in tech have CVS Caremark as our pharmacy benefit manager and they will cover Zepbound (tirzepatide) for weight loss in the Fall.
The problem is I'm too skinny now to get it!
Re: Semaglutide linked to lower predicted dementia risk
#427Earlier quoted context omitted.
Western disease and sugar heavy diets broadly speaking, which Semaglutide is a countermeasure against. Not yet a vaccine, but in due time (probably via gene therapy). Fructose also helps cancer metastases and spread. https://www.sciencealert.com/common-sugar-appears-to-loosen-...
First of all it’s a nice study. The dosages they always give are way too high and mice are rarely a reliable model. But you’re also ignoring the fact that the same study shows that glucose inhibits the behavior. So your claim that the study indicates its sugar is incorrect. The study indicates a possible impact from fructose which is countered by glucose, so the real issue is the fructose to glucose ratio. Table suga…
Additional citation:
Babies born under sugar rationing grew into adults with lower cancer risk - https://news.ycombinator.com/item?id=49345843 - August 2026
Re: Semaglutide linked to lower predicted dementia risk
#428Earlier quoted context omitted.
I don't buy that. You can buy a steak and a potato for two for less than a bag of Doritos. A banana costs far less than a candy bar. A bag of mixed nuts will provide many meals. Price out a bag of rice, a bag of beans, etc. > food companies' only interest is in maximizing profit Pleasing your customers is how profit is maximized. Besides, I bet if you were faced with two stores, one that charges $x for A, and another…
Where are you getting a steak and potato for 2 for less than a bag of Doritos? Is it a 50 lb bag of Doritos?
Today I bought over a pound of steak for $5.57. Of course, it was on sale.
Re: Semaglutide linked to lower predicted dementia risk
#429Earlier quoted context omitted.
A lot of this largely is not true. People think that paleothic humans ate a lot of meat - they did not. They ate very little meat, we eat the most meat we’ve ever eaten now. And the meat they did eat was lean game meat. It was high in unsaturated fats - like our modern day oils. Not like a steak. A steak is a product of farming. It’s a new invention, Yes oils are “refined”, but humans have been eating unsaturated oil…
People in certain regions always ate a lot of meat. For example, the Inuit don't really have anything else to eat. Nothing edible grows that far North. And they are neither obese nor suffer from classical diseases of civilization, until they start eating highly processed modern food. The Maasai are also known to eat a lot of meat and dairy.
True but the Inuits are the exception, not the rule.
It's been pretty much accepted that out ancestors (a long time ago) were scavengers, then became farmers/Livestock farmers and then industrialization.
It's only with the latest that we did start to produce meat in large quantity.
Re: Semaglutide linked to lower predicted dementia risk
#430Earlier quoted context omitted.
A lot of this largely is not true. People think that paleothic humans ate a lot of meat - they did not. They ate very little meat, we eat the most meat we’ve ever eaten now. And the meat they did eat was lean game meat. It was high in unsaturated fats - like our modern day oils. Not like a steak. A steak is a product of farming. It’s a new invention, Yes oils are “refined”, but humans have been eating unsaturated oil…
No idea where you're getting this from. The paleolithic was during an ice age full of big fatty game like sloths, mammoths, and so on. Some believe we hunted these animals to the point of extinction with a tiny population, which would imply a very high level, arguably unbelievably high, of consumption of meat. Even if we didn't hunt them to extinction we certainly did engage in relatively large scale hunting and cons…
I did read your link but it doesn't prove your point at all.
Population in specific places used to eat meat because nothing grows there, but they were an exception to the rule. It's been known that our ancestors were mostly scavengers.
Hunting animals is much more dangerous that picking strawberry, back then a cut may lead to death, a broken bone was death.