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Semaglutide linked to lower predicted dementia risk

alz-journals.onlinelibrary.wiley.com

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Re: Semaglutide linked to lower predicted dementia risk

#411

Post by loeg »

eapressoandcats wrote: post #217
SubmarineClub wrote: post #170

Earlier quoted context omitted.

> metabolic changes that make weight loss harder Which are vastly overblown. I diet every year as part of bodybuilding, at a range of intensities and durations, and have never had issues with sudden metabolic changes that make it harder to lose weight.

That’s very nice for you, but it is a phenomenon that is well documented by research: https://pmc.ncbi.nlm.nih.gov/articles/PMC4989512/

It's not as significant as most people make it out to be (also born out by the research).

Re: Semaglutide linked to lower predicted dementia risk

#412

Post by simianparrot »

cthalupa wrote: post #339
simianparrot wrote: post #300

Earlier quoted context omitted.

[flagged]

Except this entire narrative is thrown off by the fact that obesity has been a problem before any of that and is a problem in countries without any of that. Even places like Korea where you are literally shamed constantly by friends and family for being even remotely overweight has obesity growing all while having basically the exact opposite culture of what you are complaining about. Basically the only developed cou…

South Korea's obesity threshold is much lower than western Europe and the US. There you're considered obese at 25 kg/m2 or above. In Europe and the US it's 30 kg/m2.

There's also factors like this: https://biz.chosun.com/en/en-science/2026/08/17/SC54HFSN7JAU...

I didn't mean to say the cases I listed are exclusively the only ones, but I still maintain they are a major part of it.

Japan teaches accountability and taking personal responsibility -- it's a country where its capital city can get away with barely any places to dispose of your trash and not be littered. DEI is barely a thing, if at all. And it definitely does not celebrate mediocrity.

Re: Semaglutide linked to lower predicted dementia risk

#413

Post by hypertele-Xii »

ivraatiems wrote: post #65
londons_explore wrote: post #23

So has anyone managed to separate the effects of semaglutide from the effects of weight loss? If this is caused by the weight loss, it is a little disappointing that public health didn't act quicker - lots of people have been overweight for a century now, so literally 10's of millions of people could have been saved from dementia had action been taken 100 years ago.

Semaglutide was invented in the early 2000s. Weight loss is an extremely complicated and societally mediated problem that we didn't have a 'cheat code' like this for until recently.

Weight loss is extremely simple. The human body has two mutually-exclusive metabolic modes: burning sugar, and burning fat. Mode switching is automatic: if you eat sugar, your body runs sugar-burning mode and any fat you eat at the same time is stored. To lose weight, simply don't eat sugar; your body auto-switches to ketosis and burns fat reserves.

Foods with both sugar and fat make you gain weight, e.g. ice cream is 50% sugar 50% fat. Eat ice cream every day and you'll only gain weight.

The only "social problem" we now have is that women are on a power-trip rebelling against the men who used to keep them honest about eating. Hence "body positivity" from feminists.

Re: Semaglutide linked to lower predicted dementia risk

#414

Post by majkinetor »

loeg wrote: post #409
majkinetor wrote: post #348

Earlier quoted context omitted.

You should start Metformin now and thank me later.

Metformin is miserable. Why go on that over a GLP-1?

Because its OTC, xtremelly safe and and it works.

What issues do u have with it.

Re: Semaglutide linked to lower predicted dementia risk

#415

Post by pkilgore »

Didn't EVOKE fail at the primary endpoint of reducing dementia?

Sure, they hit a fucking surrogate, that's sometimes interesting for additional research.

But we have incredibly strong clinical evidece oral semaglutide did not significantly reduce clinical progression in patients with early symptomatic Alzheimer's disease.

Re: Semaglutide linked to lower predicted dementia risk

#416

Post by preg_match »

jaggederest wrote: post #384
preg_match wrote: post #371

Earlier quoted context omitted.

I'm sure you can eat a diet fairly high in meat and dairy and be healthy, IF you are lean enough and exercise enough. However, I can pretty confidently say the Intuit did not eat nearly as much meat and dairy as modern Americans. And, the meat they did eat was not the same because it was wild, not farmed. But, humans have been eating unsaturated fat from nuts, seeds, and meat for millennia. Unsaturated fat is not the…

> However, I can pretty confidently say the Intuit did not eat nearly as much meat and dairy as modern Americans. Incorrect, your points are otherwise true. Inuit diet was close to 100% animal products, way more than anyone but carnivore diet people today eat.

By percentage, sure, by absolute value, no.

Most Americans are obese, so we’re already eating way more than the intuit. Probably 1000+ calories more a day.

And then, Americans eat multiple servings of meat with every meal.

Re: Semaglutide linked to lower predicted dementia risk

#417

Post by jnovek »

dpark wrote: post #377
jnovek wrote: post #336

Earlier quoted context omitted.

I think you’re misunderstanding the fat acceptance movement. It’s about separating the illness from the person, not about obesity health. In our society it would be impossible to be unaware that obesity is unhealthy. People go out of their way to be mean to fat people. The fat acceptance movement is essentially “please don’t do that”.

It’s both. There is a very vocal contingent who insist that obesity is not unhealthy.

There are people who claim that, yes, but that’s not broadly what the movement is about.

Every philosophy or movement has outliers that misinterpret and act outside of the bounds of that movement and we understand that those outliers don’t represent the group; yet people always look to those outliers with the fat acceptance movement — the fat acceptance movement is not given the benefit of the doubt like others are.

To me that implies that there is underlying bias.

Re: Semaglutide linked to lower predicted dementia risk

#418

Post by loeg »

majkinetor wrote: post #414
loeg wrote: post #409

Earlier quoted context omitted.

Metformin is miserable. Why go on that over a GLP-1?

Because its OTC, xtremelly safe and and it works. What issues do u have with it.

It has negative side effects in many people: https://www.mayoclinic.org/drugs-supplements/metformin-oral-...

Re: Semaglutide linked to lower predicted dementia risk

#419

Post by leoedin »

wackget wrote: post #120
object-a wrote: post #106

Earlier quoted context omitted.

What is junk food? For example — are cheeseburgers and French fries junk food? What about when you make them at home, or at a fancy restaurant without artificial ingredients? Is it certain additives? If McDonalds makes a happy meal without additives, is it no longer junk food? What does treat them like cigarettes mean? Tax them? Ban them within 15 feet of a building entrance? Put warning labels? Is giving or selling…

Most of the time when people try to define healthy food vs. junk food in a fair and unbiased way, the line gets drawn at "whole foods" vs "processed foods". A typical burger meal is definitely processed food because the meat is processed mechanically and mixed from different sources (usually with added fat); the bun is made from refined flour and refined oils; and the fries are thinly-cut potatoes blanched and fried…

I don't think there's a neat categorisation. If I cook at home, starting with just vegetables and cuts of meat, at some point the food I'm making stops being "whole foods" and starts being "processed foods". But when is that?

If I cook bread at home, is that a processed food? How about if I make a steak sandwich with that bread? How about if I first pass the steak through a mincing machine? Still whole? Or processed now?

What if I add an egg, some crumbs from the bread I made earlier, and some salt and pepper. Still whole? And then I formed it into a patty and cooked it on a pan. Is it now processed?

When does it become processed and how does that look different to my stomach when I chew it?

Re: Semaglutide linked to lower predicted dementia risk

#420

Post by lostmsu »

onefish wrote: post #303
01100011 wrote: post #38

I'm a big semaglutide proponent after being on it for a year. I know research says it helps with inflammation, arthritis (separately from weight reduction), and all sorts of magical things. I lost 40 pounds in a year(230 to 190) at age 50. Great! I also went from being active and fat(weightlifting with some cardio) to basically having no energy. In the last year I've had arthritis appear in several joints. I'm awake…

I have a very similar situation: on it for about a year, 220lbs to 180 at age ~40. Also very active: weight lifting / biking / swimming and - the sport that made me realize I needed to loose weight - rock climbing. I've always been very outdoorsy-adventurous, and climbing/mountaineering is the natural sort of "end game" for this lifestyle. My weight never really got in the way of anything else in my life (maybe my se…

Do you think the lower energy levels also affect your cognition?
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