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Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

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Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#231
post #77

Earlier quoted context omitted.

If you actually had melanoma (a very aggressive type of skin cancer) you would be glad for one more chance of maybe still being alive a few years from now.

not if you dropped dead from a heart attack after your therapy. Are you familiar with vioxx ? https://www.npr.org/2007/11/10/5470430/timeline-the-rise-and...

IF you dropped dead a decade later, it would be a fantastic trade-off.

Vioxx was a long-term problem. Having that problem instead would be a great trade-off relative to untreated melanoma.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#232

Earlier quoted context omitted.

How does one control the dose for anything? Why are you worried about mRNA vaccines in particular?

Radiation dose, for example, is precisely measured - we know exactly how much radiation the body is exposed to during therapy. mRNA products work by making our cells produce the desired protein/drug. There is no way of controlling how many cells are producing the drug and for how long they are producing it - ergo there is no way of controlling the dose. I hate to break it to you but they have found people producing s…

Citation on the spike protein production?

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#233

This is great news! I think people forget how anti-skin cancer protocols even as simple as applying suntan lotion weren't as popular as recent as 50-60 years ago. Lots of "sun children" of the 50s and 60s are now feeling the repercussions of only applying baby oil and are getting hit with lots of melanoma.

My mother always covered up and always made us kids cover up. She still died of melanoma. Sun may increase the risk, but sun cream doesn't make it impossible. Cancer has no friends. Well done to the drug researchers. I have my fingers crossed someone else gets to avoid this

There's also the effect that sunscreen makes you spend more time in the sun than if you didn't use sunscreen because you think you're "protected".

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#234
post #88

Earlier quoted context omitted.

What’s funny is before the 50s and 60s everyone knew you should cover up and women wore bonnets. That too much sun was bad for you. Laura Ingalls Wilder of Little House fame (I mention this a lot as I read these to my children as an adult, and they’re a fascinating look at 1880s America) has lots of places where her mother says “put on your bonnet! Don’t get too much sun!”. We act like people in the past were ignoran…

No I think you’re looking at this wrong. They thought too much sun was bad for you because back then tanned skin was considering a mark of being poor and pale skin was a mark of being wealthy since rich people didn’t have to work outside. They also had puritanical Victorian notions of modesty and covering up. There was no knowledge linking sun exposure to cancer or negative health effects. People in the past indeed w…

Still very much the case in East Asia.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#235
post #233

Earlier quoted context omitted.

My mother always covered up and always made us kids cover up. She still died of melanoma. Sun may increase the risk, but sun cream doesn't make it impossible. Cancer has no friends. Well done to the drug researchers. I have my fingers crossed someone else gets to avoid this

There's also the effect that sunscreen makes you spend more time in the sun than if you didn't use sunscreen because you think you're "protected".

You are saying that, even if you wear sunscreen and avoid sun burn, the UV exposure will still potentially lead to skin cancer?

I'd like to see the primary research backing that up. Or be told how I misinterpreted your statement.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#236
post #205

Earlier quoted context omitted.

1. That's not what progression-free survival means. I was not pointing to PFS as OS. 2. I don't think AI was mentioned once in this press release. I did not say it was. I said it was written FOR AI trading algorithms to read and invest on. 4. The paragraph immediately following the one you clipped talks about Overall Response Rate (ORR) and throughout the release they discuss Overall Survival (OS). Someone noted this…

Yes every cancer is different, responds to different therapy, and with different survival rates. However, cancer treatment, as a whole, works. Oncologists do not prescribe incredibly intense treatments like chemotherapy out of nowhere. Chemotherapy is often not curative. Instead, it's used to both prolong life and improve quality of life. Dying from late-stage cancer is often painful and miserable. It might be shocki…

They told my father Chemo woudl add six months on his six month estimated lifespan. He died in two months cause the chemo blocked his liver. My sister in law was a chemo nurse and begged him not to get it. He died on loads of morphine. His last words were "It's all a scam!"

Sorry, you have no idea. Talk to a chemo nurse.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#237

This is great news! I think people forget how anti-skin cancer protocols even as simple as applying suntan lotion weren't as popular as recent as 50-60 years ago. Lots of "sun children" of the 50s and 60s are now feeling the repercussions of only applying baby oil and are getting hit with lots of melanoma.

>> This is great news... No this is insane news, the world is crazy and dumb. Must be all these LLMs. Stock up more than 150%, based on totally unpublished data and an X post... - The flashy 49% figures are from the old 157 only patient Phase 2, not this Phase 3 trial. The phase 2 was open label, had only 50 controls, and its randomization was disrupted. Meaning 9 patients were reassigned and the final 37 were no lon…

the stock is up 150% because if Moderna has indeed cured cancer, the stock is worth many magnitudes more than that. It's presumably based on the probability this report is indeed as promising as it is at face value. If Moderna had announced "we are 100% sure cancer is cured" the stock would've gone up much more

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#238
post #88

This is great news! I think people forget how anti-skin cancer protocols even as simple as applying suntan lotion weren't as popular as recent as 50-60 years ago. Lots of "sun children" of the 50s and 60s are now feeling the repercussions of only applying baby oil and are getting hit with lots of melanoma.

What’s funny is before the 50s and 60s everyone knew you should cover up and women wore bonnets. That too much sun was bad for you. Laura Ingalls Wilder of Little House fame (I mention this a lot as I read these to my children as an adult, and they’re a fascinating look at 1880s America) has lots of places where her mother says “put on your bonnet! Don’t get too much sun!”. We act like people in the past were ignoran…

That's the right thing for the wrong reason, which can actually significantly forestall figuring out what's actually going on.

Scurvy is like that. They figured out that if you give sailors a ration of fresh fruit juice they don't get scurvy - this works because the fresh fruit juice has Vitamin C and Scurvy is just Vitamin C deficiency. But they didn't know why it worked - why would a cow, a mango, a lettuce, and indeed basically everything else have a chemical in it that humans can't synthesize ? That's crazy. Except, nope, that's really what's going on. At some point an ancestor deleted the synthesis pathway for this chemical, their offspring weren't bothered because fresh literally everything has the chemical anyway, so the deletion stuck around.

At the same time ships get quite a lot faster, travel across the Atlantic is now rapid enough that even if you deliberately abstained from Vitamin C you wouldn't get scurvy, your body hoards many chemicals it needs (a few must be made "fresh" but most can be hoarded) and only develops issues when the hoarded ascorbic acid is exhausted after a few weeks. But they don't know that, and so when they swap a working solution (store fruit, squeeze the juice out, drink fresh juice) for a non-working solution (squeeze the juice, preserve that, drink preserved juice) the apparent results do not change.

Until they do something more extreme. Go to Antarctica, which is incredibly hostile to life anyway, and then stay there for months. Despite your magic preserved fruit juice you get scurvy. The juice wasn't magic, and eventually you will figure out it was the freshness which was magic and from there that there really is a chemical found in cows, mango, lettuce and basically everything alive which we cannot synthesize. Ascorbic acid, Vitamin C.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#239

This is great news! I think people forget how anti-skin cancer protocols even as simple as applying suntan lotion weren't as popular as recent as 50-60 years ago. Lots of "sun children" of the 50s and 60s are now feeling the repercussions of only applying baby oil and are getting hit with lots of melanoma.

>> This is great news... No this is insane news, the world is crazy and dumb. Must be all these LLMs. Stock up more than 150%, based on totally unpublished data and an X post... - The flashy 49% figures are from the old 157 only patient Phase 2, not this Phase 3 trial. The phase 2 was open label, had only 50 controls, and its randomization was disrupted. Meaning 9 patients were reassigned and the final 37 were no lon…

150% increase is because it started from a low point. Moderna's stock lost 94% value after Covid. Stock price speaks to investors' enthusiasm, there is no algorithm.

> This phase 3 news so far is nothing more than a press release.

Can you find a case where a press release after phase 3 was later proven wrong? They do have the data, and most likely the data is positive. They're talking about FDA's approval as soon as late 2027, which is fairly soon.

Do you know what would be more dramatic than stock gaining 150%? that'd be the stock crashing if the press release turned out to be wrong. Follow the money if you are skeptical. See who's selling.

> The flashy 49% figures are from the old 157 only patient Phase 2, not this Phase 3 trial.

There are 1,100 patients in phase 3. More evidence that they're pretty confident.

This is great news.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#240
post #233

Earlier quoted context omitted.

There's also the effect that sunscreen makes you spend more time in the sun than if you didn't use sunscreen because you think you're "protected".

You are saying that, even if you wear sunscreen and avoid sun burn, the UV exposure will still potentially lead to skin cancer? I'd like to see the primary research backing that up. Or be told how I misinterpreted your statement.

Yes, 100%. It's the same reason that my kids are able to tan through the same sunscreen application regimen that leaves me pale.

Source: My Mohs surgeon. And 3 skin cancer surgeries (so far).

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