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Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

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Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#191

In other news, your barber thinks you need a haircut. Until there is a proven net overall health benefit to this therapy, I wouldn't waste much ink on it. Also, can someone please tell me how one controls the dose for an mRNA therapy ?

How does one control the dose for anything? Why are you worried about mRNA vaccines in particular?

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#192
post #88

Earlier quoted context omitted.

What’s funny is before the 50s and 60s everyone knew you should cover up and women wore bonnets. That too much sun was bad for you. Laura Ingalls Wilder of Little House fame (I mention this a lot as I read these to my children as an adult, and they’re a fascinating look at 1880s America) has lots of places where her mother says “put on your bonnet! Don’t get too much sun!”. We act like people in the past were ignoran…

No I think you’re looking at this wrong. They thought too much sun was bad for you because back then tanned skin was considering a mark of being poor and pale skin was a mark of being wealthy since rich people didn’t have to work outside. They also had puritanical Victorian notions of modesty and covering up. There was no knowledge linking sun exposure to cancer or negative health effects. People in the past indeed w…

People were aware of heatstroke and sunstroke before the Victorians. There's biblical references to heatstroke and even in Roman and Greek texts.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#193

In other news, your barber thinks you need a haircut. Until there is a proven net overall health benefit to this therapy, I wouldn't waste much ink on it. Also, can someone please tell me how one controls the dose for an mRNA therapy ?

A successful phase 3 trial means that the drug is actually effective, not just safe. That's what they test in phase 3.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#194
post #42

Earlier quoted context omitted.

Because, it is always all about you...

Clearly his issue is not understanding its actually all about 'grandma'.

It's about protecting each other, basic empathy. Doing the bare minimum to and taking miniscule risk to protect the lives of people around you. Sorry that's hard to understand.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#195

My father is currently dying of malignant melanoma with brain metastasis... I wish this treatment was available a few years ago.

Immune therapy didn't help? Darn.

Immune therapy is hit or miss. Friends lung cancer was exquisitely sensitive to it. Stage 4 to no sign of disease. Another friend with melanoma immune therapy didn't seem to help at all.

Melanoma is usually completely resistant to traditional cancer drugs. So that sometimes immune therapy works is very welcome.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#196
post #42

Earlier quoted context omitted.

Because, it is always all about you...

That's the definition of a personal decision.

I might decide to shit on your front porch every morning. It is the definition of a personal decision.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#198

Earlier quoted context omitted.

Vaccines that have a large impact on transmission and infection are there not just for you but for your community. The covid shots were good against hospitalization and death in older folks, but they were not great at preventing infection or transmission (despite what you may have gleaned from the speakers blaring ads in every public setting for all that time). You can fall back to the "flooding the hospitals" argume…

You're misinterpreting data here. You are conflating the fact that the clinical trials didn't measure infection/transmission (which is very hard to do in a clinical trial) with the distinct claim that they didn't reduce transmission in reality. The vaccines were extremely effective at reducing transmission during the first waves of COVID, where such an intervention was most valuable. And due to viral growth dynamics,…

All I'm saying is if you sum up the time (between vaccine release and today) that a person was strongly protected from covid infection and transmission, it's a relatively small portion of that time.

Thats my pushback against gp's argument that you have to give this thing to your young kids to protect me.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#199
post #50

I for one would like to see the data rather than a press release. Is this even serious? A press release with no link to outside twitter? I feel like everything companies, and presidents, say now is directly geared to triggering AI trades. The only thing they are looking at with this drug is people living one more month over existing drugs. THIS IS NOTHING. "The median PFS (progression-free survival) for KEYTRUDA was…

1. That's not what progression-free survival means. 2. I don't think AI was mentioned once in this press release. 3. This drug was approved for trial in 2014, so if it had something to do with deep learning, that would actually be a massive announcement. 4. The paragraph immediately following the one you clipped talks about Overall Response Rate (ORR) and throughout the release they discuss Overall Survival (OS). 5.…

My interpretation of "triggering AI trades" is about tricking AI into buying stock, not tricking people into buying AI stocks.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#200

Earlier quoted context omitted.

Individualized immune cancer therapy has been touted as the next big thing for half a century. It's nothing new, and with few exceptions, such as skin cancer, has failed to yield much. scientists, for decades, have tired to harness the immune system to attackcancer and it almost never works.

Personalized mRNA vaccines are in fact, extremely new, and only made possible by recent advances across multiple fields. This comment reveals a total lack of basic understanding on this topic.

> This comment reveals a total lack of basic understanding on this topic.

My thoughts as well, Keytruda alone has been a miracle to many many people at this point (quoting GP: "scientists, for decades, have tired [sic] to harness the immune system to attack cancer and it almost never works."), I frequently get ads for local CAR-T centers (unthinkable a little over a decade ago)

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