Live data from Hacker News

Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

twitter.com

31–40 of 330 posts

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#31
post #17

Earlier quoted context omitted.

oh nice. If it goes up another 100% I may not lose money on this stock anymore.

I mean, this appears to be validation of mRNA in general, right?

Saving a couple million people in the pandemic wasn’t validation enough?

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#32

Earlier quoted context omitted.

I mean, this appears to be validation of mRNA in general, right?

Saving a couple million people in the pandemic wasn’t validation enough?

100%. What I meant to say was that this proves that it wasn't somehow a one trick pony.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#33

Earlier quoted context omitted.

> For all the hate I have for the COVID vaccine Can you clarify that? It saved 100K+ lives even by incredibly conservative estimates, and allowed life to returned to normal at least a year earlier than otherwise.

I can't speak for other people but I was upset to enter a medical era where bureaucrats were forcing medical decisions on me. I was forced to get it or lose my job despite 1) working remotely, 2) having already had Covid and 3) being healthy and not at risk of Covid death but being the largest risk for myocarditis.

Is that when you entered that era? Or did you enter it when you were a newborn in the hospital, or a kid entering school?

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#34

This is great news! I think people forget how anti-skin cancer protocols even as simple as applying suntan lotion weren't as popular as recent as 50-60 years ago. Lots of "sun children" of the 50s and 60s are now feeling the repercussions of only applying baby oil and are getting hit with lots of melanoma.

[flagged]

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#35
post #27

Earlier quoted context omitted.

> For all the hate I have for the COVID vaccine Can you clarify that? It saved 100K+ lives even by incredibly conservative estimates, and allowed life to returned to normal at least a year earlier than otherwise.

[flagged]

You got RFK because half the population thought they were unique snowflakes who could not abide by the same simple rules as everyone else. The price he'll extract is significant impacts on health, wealth and well-being.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#36
post #14

Earlier quoted context omitted.

What are the reasons for the hate of the COVID vaccine?

Probably one of the most polarizing issues of the last 5 years.

"Polarizing" is a word that kind of applies, especially if one is trying to be polite, but really it's one of the most politically disinformed issues in a long long time.

A bunch of grifters pushed fear, uncertainty, and doubt for personal gain, at the expense of the health of the nation. I try not to blame people who got tricked, but at some point we need to treat people like adults who are responsible for their own actions, and hold them accountable for the harm they perpetuate by believing BS and acting on it.

A democracy cannot function when its members are low-functioning, and when bad information dominates. Those who spread disinformation, relish the conspiracy and disinformation because it makes them feel special emotionally, and wallow in the mess of it, are hurting us all.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#37
post #34

This is great news! I think people forget how anti-skin cancer protocols even as simple as applying suntan lotion weren't as popular as recent as 50-60 years ago. Lots of "sun children" of the 50s and 60s are now feeling the repercussions of only applying baby oil and are getting hit with lots of melanoma.

[flagged]

Article: "two forms of rare melanoma are not caused by exposure to the sun.."

> Most skin cancers are not a big deal, and even Melanomas can vanish on their own

PSA: don't take medical advice from internet comments

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#38

Earlier quoted context omitted.

People were assured that COVID vaccine mRNA would disappear within days and the spike protein would short-lived. Yet Yale-led researchers later detected circulating S1 and full-length spike as late as 709 days after vaccination. They also left the public in the dark about the risk of vaccine-associated myocarditis, especially in young males, many of whom experienced permanent heart tissue damage. That is a massive ga…

> They also left the public in the dark about the risk of vaccine-associated myocarditis, especially in young males, many of whom experienced permanent heart tissue damage. Not true. This was correctly disclosed in the trial results as a super super super tail risk. Once they realized that the (minuscule) risk could be even further mitigated by simply spacing out the booster schedule, they adjusted that (Feb 2022). N…

again. over how long.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#39
post #27

Earlier quoted context omitted.

> For all the hate I have for the COVID vaccine Can you clarify that? It saved 100K+ lives even by incredibly conservative estimates, and allowed life to returned to normal at least a year earlier than otherwise.

[flagged]

Except that your children are still vectors for getting others sick. Vaccines are there not just for you but your community.
Post reply on HN