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Semaglutide linked to lower predicted dementia risk

alz-journals.onlinelibrary.wiley.com

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Re: Semaglutide linked to lower predicted dementia risk

#401

Post by Lagoon3384_SWE »

whatisthiseven wrote: post #343
Lagoon3384_SWE wrote: post #333

Very american thread and comments. At most I was 24 BMI and I felt like a fat bastard during COVID. Work from home in sweatpants and I got up to 24 BMI. 77-78kg, 182cm. I just did not weigh myself so I actually did not notice I had gained! But I did and decided to do something about it. But I lost the weight pretty quickly. I grew up at 60-65kg and that is where I feel at home in my body. I feel like myself basically…

Yes, the world is very aware of how to lose weight. Turns out knowledge doesn't work very well, or rather loses efficacy in certain environments. Individuals can vary in their ability to regulate the hunger response signal they feel, which is stronger with higher weight (as your body now needs more calories to maintain its larger size). GLP-1s don't appear to have such an efficacy loss and do work well. Sometimes wit…

I like to compare weight to smoking.

Here in Sweden only 5% smoke now.

40-50% used to smoke in the 60s.

It's like we have forgotten how to change peoples behaviours? Even when the answer is right in front of us in the past.

Growing up in the 90s and 00s "never smoke" campaigns were relentless and it has born fruit. Thankfully, also my parents never smoked and instilled how bad it is. But the public campaigns, the smoke packet images, the price increases.

So yes a lot of it is global incentives.

But you can still be an individual.

Same with clothes, growing up everyone wanted to be black in 2005 or emo. I had to re-discover good menswear like OCBDs and chinos. It does take some effort.

So, I like to see it as a differentiatory. Yes most is environment. I grew up with a skinny and active family. In a Swedish city. Truly obese people are rare and something IS wrong with them. Mentally and/or physically. You cannot just give up and blame everything else.

Summary from you feels like: "aaah help the food is teleporting into my mouth heeelp!!"

I would honestly love to have a discord or phonecall with all disagreeers with my points.

Cheers!

Re: Semaglutide linked to lower predicted dementia risk

#402

Post by kccqzy »

sowbug wrote: post #388
01100011 wrote: post #205

Earlier quoted context omitted.

I'm trying but I've got a toddler and now it seems like every joint hurts. No time to get to a gym and no room for a decent home gym. I did start to do back day again at the Y when we go on the weekend for the pool. We'll see...

One small thing to try is so-called Asian squats while you're playing with your kid. Hip and groin neuralgia started suspiciously soon after my tirzepatide weight loss. I seem to have gotten it under control after mobility exercises centered around squatting. It took almost six months to get from falling backwards to being able to squat flat-footed. Now it's a comfortable and useful stance. My theory is the weight lo…

The Asian squat has a very different focus than the squats I do in the gym. In the gym, a barbell back squat puts 200+ lb of weight on my shoulder, I squat down, hold for one second and then come up. In contrast the Asian squat needs no weight, but I need to stay at the bottom position for many seconds. It most likely exercises muscles in a different way than my usual squats. I can hardly do the Asian squats because I don’t practice holding at the bottom position.

Re: Semaglutide linked to lower predicted dementia risk

#403

Post by 01100011 »

loeg wrote: post #265
skirmish wrote: post #255

Earlier quoted context omitted.

A pair of adjustable dumbbells in the corner of the living room is still very doable. Lots of bodyweight exercises too you could look into.

Back squats and deadlifts are both unreasonably effective, and impossible to load sufficiently with dumbbells.

Yeah, this is my problem. I love deadlifts. I even have a bar and several hundred pounds of plates. But they sit under junk in my garage with no hope for unburying them until next year. I have 100lbs of adjustable dumbbells but that's just not the same for me. But in either case the energy and motivation are just not there. I used to love the gym or even working out at home but now meh.

Re: Semaglutide linked to lower predicted dementia risk

#404

Post by 0xcde4c3db »

cthalupa wrote: post #339
simianparrot wrote: post #300

Earlier quoted context omitted.

[flagged]

Except this entire narrative is thrown off by the fact that obesity has been a problem before any of that and is a problem in countries without any of that. Even places like Korea where you are literally shamed constantly by friends and family for being even remotely overweight has obesity growing all while having basically the exact opposite culture of what you are complaining about. Basically the only developed cou…

Yeah, it's almost impressive how often hypotheses for what's causing rising obesity rates simply ignore actual data. I haven't been able to find it again, but a while back I stumbled on a journal article that was basically some epidemiologists ranting about this. IIRC there are whole categories of proposed causes that you can eliminate just based on the fact that that the rise is correlated across age groups.

Re: Semaglutide linked to lower predicted dementia risk

#405

Post by dev_l1x_be »

eapressoandcats wrote: post #126
Aurornis wrote: post #107

Earlier quoted context omitted.

> The medical establishment and big pharma simple ignores the fact that the biggest health risk for a human being is the "modern" high sugar diet The medical establishment isn’t ignoring this at all. They’ve been pushing for healthier diets forever. Primary doctors have always been pushing for healthy eating. That doesn’t mean patients welcome the advice or follow it. Everyone knows that eating high sugar diets and b…

There was a fringe that said being overweight was not unhealthy, but the more salient points were the following: 1. BMI was basically just pulled out of a hat, and it turns out that for many health concerns, the overweight class does better than the normal weight class, with the actual “clearly worse” outcomes really coming up as you trend into obesity. 2. Environmental and genetic factors are huge contributors to pe…

I think it would be enough to ban high fructose corn syrup.

Re: Semaglutide linked to lower predicted dementia risk

#406

Post by basilgohar »

preg_match wrote: post #293
basilgohar wrote: post #266

Earlier quoted context omitted.

There are other significant factors beyond the ones you mentioned, such as inflammation due to processed foods, certain oils, and more that are common in industrialized medicine. Plenty of anecdata of people who stopped eating certain categories of food and certain conditions they had for a long time went away. In my son's case, a severe case of eczema that persisted for years went away in a matter of weeks after we…

A lot of this largely is not true. People think that paleothic humans ate a lot of meat - they did not. They ate very little meat, we eat the most meat we’ve ever eaten now. And the meat they did eat was lean game meat. It was high in unsaturated fats - like our modern day oils. Not like a steak. A steak is a product of farming. It’s a new invention, Yes oils are “refined”, but humans have been eating unsaturated oil…

If you got out of my comment that oils and fats are bad, then you didn't understand my point. I was emphasizing on the negative effects of processed foods.

Re: Semaglutide linked to lower predicted dementia risk

#407

Post by loeg »

01100011 wrote: post #403
loeg wrote: post #265

Earlier quoted context omitted.

Back squats and deadlifts are both unreasonably effective, and impossible to load sufficiently with dumbbells.

Yeah, this is my problem. I love deadlifts. I even have a bar and several hundred pounds of plates. But they sit under junk in my garage with no hope for unburying them until next year. I have 100lbs of adjustable dumbbells but that's just not the same for me. But in either case the energy and motivation are just not there. I used to love the gym or even working out at home but now meh.

Are you done losing weight? It will probably feel better to go back to maintenance calories than to be in a deficit. And consider lowering your dose, gradually.

Re: Semaglutide linked to lower predicted dementia risk

#408

Post by loeg »

throwaway82931 wrote: post #110
londons_explore wrote: post #23

So has anyone managed to separate the effects of semaglutide from the effects of weight loss? If this is caused by the weight loss, it is a little disappointing that public health didn't act quicker - lots of people have been overweight for a century now, so literally 10's of millions of people could have been saved from dementia had action been taken 100 years ago.

All my immediate family members are obese. I'm not (BMI 24.5, borderline overweight at the high end of normal, highest lifetime BMI was 29.5), but that's through strenuous, exhausting effort over decades. I also exercise regularly, though I've learned over time how disconnected exercise is from weight management. At my weight, I'm not a candidate for going on a GLP-1. I'm sure I could find an unethical doctor to pres…

> At my weight, I'm not a candidate for going on a GLP-1. I'm sure I could find an unethical doctor to prescribe it if I looked hard enough,

FWIW, BMI as low as 27.0 is on-label ish, so if you went to an ordinary doctor with some rocks in your pocket you might be able to get a prescription relatively easily. I got a prescription from my GP with a nominal BMI right around there (I didn't take my shoes off or empty my pockets for the scale).

Re: Semaglutide linked to lower predicted dementia risk

#409

Post by loeg »

majkinetor wrote: post #348
throwaway82931 wrote: post #110

Earlier quoted context omitted.

All my immediate family members are obese. I'm not (BMI 24.5, borderline overweight at the high end of normal, highest lifetime BMI was 29.5), but that's through strenuous, exhausting effort over decades. I also exercise regularly, though I've learned over time how disconnected exercise is from weight management. At my weight, I'm not a candidate for going on a GLP-1. I'm sure I could find an unethical doctor to pres…

You should start Metformin now and thank me later.

Metformin is miserable. Why go on that over a GLP-1?

Re: Semaglutide linked to lower predicted dementia risk

#410

Post by loeg »

zhivota wrote: post #275
Aurornis wrote: post #50

Earlier quoted context omitted.

That is the question now. Some studies have some early evidence that GLP-1s might reduce inflammation markers a little more than weight loss alone. Giving GLP-1s to normal weight people doesn’t work well because they can have to work harder to maintain their weight. That can be a real problem as people get older where maintaining muscle mass is important for quality of life and longevity. I remember how hard it was t…

I'm normal weight and am on a low dose (1mg every 10 days) of tirzepatide. I'm able to maintain my weight at this dose, and I've seen improvements in inflammation and other blood markers as well. It's not impossible, it's just difficult to do within the normal health system parameters (specific dosages tested for weight loss, etc.). I use a gray market supplier direct from China and reconstitute the dose myself.

I have no trouble eating maintenance calories at 25.0 BMI on 3.5-4.5 mg/wk of tirzepatide, lol. (1mg every 10 days normalizes to 0.7mg/wk.)
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