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Semaglutide linked to lower predicted dementia risk

alz-journals.onlinelibrary.wiley.com

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Re: Semaglutide linked to lower predicted dementia risk

#321

Post by swalsh »

throwaway82931 wrote: post #110
londons_explore wrote: post #23

So has anyone managed to separate the effects of semaglutide from the effects of weight loss? If this is caused by the weight loss, it is a little disappointing that public health didn't act quicker - lots of people have been overweight for a century now, so literally 10's of millions of people could have been saved from dementia had action been taken 100 years ago.

All my immediate family members are obese. I'm not (BMI 24.5, borderline overweight at the high end of normal, highest lifetime BMI was 29.5), but that's through strenuous, exhausting effort over decades. I also exercise regularly, though I've learned over time how disconnected exercise is from weight management. At my weight, I'm not a candidate for going on a GLP-1. I'm sure I could find an unethical doctor to pres…

You can probably get a prescription for a low dose, but you'll be self pay.

Re: Semaglutide linked to lower predicted dementia risk

#323

Post by acuteaura »

jvidalv wrote: post #317
cloudie78 wrote: post #311

Earlier quoted context omitted.

It’s in broad terms weight loss related. More specifically blood glucose and insulin regulation which can be out of whack even if you’re not diabetic on paper. This is why you’ll see people claiming they’re not diabetic but still saw improvement from Ozempic and friends. Their insulin and glucose regulation was spoke. in casual terms “fucked”. GLP-1 receptor agonists such as semaglutide act partly through the brain t…

[flagged]

There is a fine line between being opposed to fat acceptance and thinking performative cruelty works.

(It's does not. It made me so much worse. I have nothing but bad things to say about the medical "professional" who catastrophized my diagnosis to "wake me up" and then shrugged when my response was depressed resignation.)

Re: Semaglutide linked to lower predicted dementia risk

#324

Post by owebmaster »

acuteaura wrote: post #323
jvidalv wrote: post #317

Earlier quoted context omitted.

[flagged]

There is a fine line between being opposed to fat acceptance and thinking performative cruelty works. (It's does not. It made me so much worse. I have nothing but bad things to say about the medical "professional" who catastrophized my diagnosis to "wake me up" and then shrugged when my response was depressed resignation.)

You can't depend on people being nice to take care of your own health.

Re: Semaglutide linked to lower predicted dementia risk

#325

Post by swalsh »

miki123211 wrote: post #115

I swear, Semaglutide is reverse Asbestos. It's something we found and started using to one specific problem, but it later turned out that it has lots of other, extremely wide-ranging consequences. Except that in this case, these consequences are positive.

Calling it now, the downside is the effects are most apparent on higher dosages, but you cant take higher dosages forever. Eventually you run out of body fat, have go reduce the dose, and the benefits dither.

Re: Semaglutide linked to lower predicted dementia risk

#326

Post by abirch »

cloudie78 wrote: post #311
londons_explore wrote: post #23

So has anyone managed to separate the effects of semaglutide from the effects of weight loss? If this is caused by the weight loss, it is a little disappointing that public health didn't act quicker - lots of people have been overweight for a century now, so literally 10's of millions of people could have been saved from dementia had action been taken 100 years ago.

It’s in broad terms weight loss related. More specifically blood glucose and insulin regulation which can be out of whack even if you’re not diabetic on paper. This is why you’ll see people claiming they’re not diabetic but still saw improvement from Ozempic and friends. Their insulin and glucose regulation was spoke. in casual terms “fucked”. GLP-1 receptor agonists such as semaglutide act partly through the brain t…

Jason Fung has preached against modern processed foods that destroy insulin sensitivity. Even artificial sweeteners can raise Insulin levels. His book "The Obesity Code" is a must read and discusses some of the pathways that link insulin and leptin (a hormone associated with eating)

TLDR; I'm a Fungster: https://www.youtube.com/channel/UCoyL4iGArWn5Hu0V_sAhK2w

Re: Semaglutide linked to lower predicted dementia risk

#328

Post by raverbashing »

declan_roberts wrote: post #39
01100011 wrote: post #27

Earlier quoted context omitted.

Semaglutide cleared my liver fat and fixed my moderate NAFLD in a matter of months. Why is retatrutide necessary?

Retatrutide has a specific mechanism for clearing liver fat (glucagon) which makes it one of the most effective ways to treat T2D. This is the 3rd agonist not found in semaglutide or tirzepatide.

Honestly this is overrated.

Getting the person to a caloric deficit is already 90% of the work. And that will make glucagon rise

Re: Semaglutide linked to lower predicted dementia risk

#329

Post by degamad »

refurb wrote: post #313
bluefirebrand wrote: post #274

Earlier quoted context omitted.

It can be very hard to eat a healthy diet if you're poor or if you live in a food desert, or you have a dietary restriction, or some allergies...

I disagree on the “if you’re poor”. I find eating healthy cheaper. You can prepare healthy meals from basic and cheap foodstuffs like vegetables, whole grains and legumes, eggs, low cost meat cuts etc. You can prepare delicious meals for under $1 each. Buying prepared unhealthy foods is what is expensive.

> I find eating healthy cheaper.

Being poor is very expensive.

> You can prepare delicious meals for under $1 each.

If you have the time and resources to do so.

Re: Semaglutide linked to lower predicted dementia risk

#330

Post by kelnos »

SubmarineClub wrote: post #170
eapressoandcats wrote: post #119

Earlier quoted context omitted.

They also clearly have some impacts on metabolism. It’s well known that a challenge with dieting isn’t just eating less, it’s metabolic changes that make weight loss harder. GLP-1’s avoid that.

> metabolic changes that make weight loss harder Which are vastly overblown. I diet every year as part of bodybuilding, at a range of intensities and durations, and have never had issues with sudden metabolic changes that make it harder to lose weight.

"This doesn't happen to me, so clearly it doesn't happen to enough other people to be a real thing."

Also consider that, as a bodybuilder, everything about you that matters to this discussion is significantly different from someone who is not a bodybuilder, which is most people.

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