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Semaglutide linked to lower predicted dementia risk

alz-journals.onlinelibrary.wiley.com

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Re: Semaglutide linked to lower predicted dementia risk

#281

Post by SwamyM »

wildrice wrote: post #267
Suppafly wrote: post #253

Earlier quoted context omitted.

I really wish my insurance would cover GLP-1s, because I think reduction in fatty liver and other ancillary benefits, along with the weight loss, would be medically helpful for me.

I was paying $1400 a month of my GLP-1 (on top of the $2400 monthly health insurance premium). I eventually just bought a batch from a reputable online compounding pharmacy for a very small fraction of that (about 12 months of meds at a time), and send one of the vials in for testing at a mass spectrometer for about $500.

Would you mind sharing the online pharmacy and the testing facility you used?

I've been wary of using online pharmacies due to concerns with knowing what's legitimate and what's not, so maybe a recommendation would help.

If you don't want to share publicly, can you put you contact info in your profile and I'll reach out to you?

Re: Semaglutide linked to lower predicted dementia risk

#282

Post by phil21 »

antinomicus wrote: post #43
declan_roberts wrote: post #24

If you're overweight or especially if you're T2D I highly encourage you to discuss GLP-1 with your doctor. If you're T2D then get research retatrutide which looks to be an actual cure for T2D by clearing liver fat. It should be released early next year but research-use is available and what everybody is taking. Companies like finnrick do public testing of research peptides and a good place to gather names.

I’m on tirzepatide right now from Eli lily, and I’ve been very interested in Reta, but I can’t say that I jump at the chance to inject something into myself that hasn’t been tested directly on the actual thing I’m about to put into my body. I know there are testing companies that will test certain sources but it’s not like they’ve tested the vial you get. If there’s some kind of pathogen or bacteria or whatever in th…

> I know there are testing companies that will test certain sources but it’s not like they’ve tested the vial you get.

It's why you order a decent amount of it (e.g. 2 years supply, it lasts forever in a freezer) and pay for your own randomized testing of the batch you got. You go direct to the source, not via the middle men selling it for 10x markup on a per-vial basis.

Certainly not perfect, and it adds significant cost - but still way cheaper than the regular sources via pharmacy for Zepbound.

I'm not convinced reta really shows that greater of results than tirz though. YMMV significantly here. Tirz is already so effective you are chasing marginal gains for the most part.

Re: Semaglutide linked to lower predicted dementia risk

#283

Post by musicale »

to11mtm wrote: post #97
hattmall wrote: post #42

Earlier quoted context omitted.

Treat junk food like cigarettes

And have a real conversation around Corn syrup. Even today, a Soda with 'real sugar', at least for me, is far more satiating for thirst or a 'quick sweet treat' than the same brand/'flavor' using corn syrup, that includes both the big chains as well as the local names. If I drink a soda with sugar in it, I usually wind up wanting water after. If I drink something with corn syrup, I usually just want more of whatever…

Research results notwithstanding, my anecdata suggest that sugar soda tastes better, and I am not quite sure why. I think it might have better flavor overtones or better mouth feel or something. Less gluey somehow even though there shouldn't be any difference. Maybe the sugar recipes are better in ways unrelated to the sweetener (and bottled soda is also usually better than canned, but fountain sugar soda still seems better than fountain corn syrup soda) or maybe the processing is subtly different.

Re: Semaglutide linked to lower predicted dementia risk

#284

Post by object-a »

phil21 wrote: post #280
object-a wrote: post #106

Earlier quoted context omitted.

What is junk food? For example — are cheeseburgers and French fries junk food? What about when you make them at home, or at a fancy restaurant without artificial ingredients? Is it certain additives? If McDonalds makes a happy meal without additives, is it no longer junk food? What does treat them like cigarettes mean? Tax them? Ban them within 15 feet of a building entrance? Put warning labels? Is giving or selling…

> For example — are cheeseburgers and French fries junk food? What about when you make them at home, or at a fancy restaurant without artificial ingredients? Is it certain additives? If McDonalds makes a happy meal without additives, is it no longer junk food? Yes, this is all junk food. It's not that difficult. Eaten in moderation these things are fine. But they are highly palatable calorie dense meals that are not…

Lean ground beef, bread, cheese, and a small salad are not “junk food” in themselves, but when you stack them into a cheeseburger they become junk food. Meanwhile salad entrees at several restaurants have more calories, sodium, and sugar than a Big Mac, but would be seen as healthy choices.

The reason point 2 is hard is because it’s really difficult to actually draw the line between normal food and junk/ultraprocessed foods in a way that can regulated. You can give guidelines on what a balanced diet should look like and warn away from excess consumption of certain foods, but bans or restrictions are hard.

Well, except for maybe sodas

Re: Semaglutide linked to lower predicted dementia risk

#285

Post by cyberax »

ivraatiems wrote: post #65
londons_explore wrote: post #23

So has anyone managed to separate the effects of semaglutide from the effects of weight loss? If this is caused by the weight loss, it is a little disappointing that public health didn't act quicker - lots of people have been overweight for a century now, so literally 10's of millions of people could have been saved from dementia had action been taken 100 years ago.

Semaglutide was invented in the early 2000s. Weight loss is an extremely complicated and societally mediated problem that we didn't have a 'cheat code' like this for until recently.

Semaglutide was patented only in 2018. The previous medication was liraglutide.

It behaved similarly but had a half-life of only a few hours. It required daily injections, and you could feel its effects wax and wane throughout the day.

Re: Semaglutide linked to lower predicted dementia risk

#286

Post by wtetzner »

NorthSouthNorth wrote: post #185
SubmarineClub wrote: post #167

Earlier quoted context omitted.

[flagged]

I think this is easy to say as a healthy eater (I am one too, always have been). However, unlearning a lifetime of bad habits is hard. But yeah, it's costing nations billions that could be better spent.

It's not just habits. It changes the composition of your gut microbiome, hormones, etc. All of that can make changing your diet much harder than one might think.

Re: Semaglutide linked to lower predicted dementia risk

#287

Post by tbugrara »

preg_match wrote: post #223
aucisson_masque wrote: post #192

Earlier quoted context omitted.

Could be just because you stopped eating bad food. Things improve dramatically once you limit your intake of industrialized food.

Not that dramatically. Things like fatty liver take a long time to reverse. It’s not like you stop eating junk food and then suddenly your body is chilling. No, the damage is done and takes a long time to repair. It’s like smoking. You can benefits from quitting smoking within 20 minutes. But to reach the full benefit and reversal, you need 15 years.

This isn't true, fatty liver can improve very quickly. Where are you getting "15 years" from?

Re: Semaglutide linked to lower predicted dementia risk

#288

Post by dripdry45 »

object-a wrote: post #150
wackget wrote: post #120

Earlier quoted context omitted.

Most of the time when people try to define healthy food vs. junk food in a fair and unbiased way, the line gets drawn at "whole foods" vs "processed foods". A typical burger meal is definitely processed food because the meat is processed mechanically and mixed from different sources (usually with added fat); the bun is made from refined flour and refined oils; and the fries are thinly-cut potatoes blanched and fried…

Why does grinding the meat at home make a huge difference vs grinding it in a factory? Depending on the cut you choose, the condiments you add, and the portion size, a hamburger at home could be Lot less healthy than a McDonald’s burger. McDonald’s patties don’t have any fillers afaict. The point is that “junk food” is a pretty amorphous and vague category. If you want to enforce portion or calorie restrictions you c…

The additives to the meat. Has to retain its color, be preserved, and they also add pink slime to it. McDonald’s adds soy, I believe, and there are all kinds of other things that go into it. If you grind your meat at home you’re going to get some delicious burger.

Heh, grind your meat

Re: Semaglutide linked to lower predicted dementia risk

#289

Post by taneq »

wao0uuno wrote: post #263
agos wrote: post #219

Earlier quoted context omitted.

If it’s not too hard why are people not doing it?

Because not doing it is even easier.

Well now we’ve just moved the goal posts with the “easy” and “hard” labels on them, and nothing of value was said.

Re: Semaglutide linked to lower predicted dementia risk

#290

Post by taneq »

WarmWash wrote: post #67
Aurornis wrote: post #50

Earlier quoted context omitted.

That is the question now. Some studies have some early evidence that GLP-1s might reduce inflammation markers a little more than weight loss alone. Giving GLP-1s to normal weight people doesn’t work well because they can have to work harder to maintain their weight. That can be a real problem as people get older where maintaining muscle mass is important for quality of life and longevity. I remember how hard it was t…

My assumption was that GLP-1's don't suppress appetite so much as suppress the compulsion to eat when not necessary/more than necessary?

What is appetite?
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