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Semaglutide linked to lower predicted dementia risk

alz-journals.onlinelibrary.wiley.com

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Re: Semaglutide linked to lower predicted dementia risk

#181

Post by ThrowawayTestr »

amrrs wrote: post #49
01100011 wrote: post #38

I'm a big semaglutide proponent after being on it for a year. I know research says it helps with inflammation, arthritis (separately from weight reduction), and all sorts of magical things. I lost 40 pounds in a year(230 to 190) at age 50. Great! I also went from being active and fat(weightlifting with some cardio) to basically having no energy. In the last year I've had arthritis appear in several joints. I'm awake…

Is it kind of the stuff where the benefits outweigh the side effects? I'm just scared of the unknowns with the drug with such overwhelming positive research. Maybe, I'm a paranoid person but I'm unable to believe that such a powerful drug isn't without any side effect, clinically proven.

The drug has been in use for 20 years. The only side effect I've had is nausea and it passes after a few minutes.

Re: Semaglutide linked to lower predicted dementia risk

#182

Post by matthewdgreen »

01100011 wrote: post #38

I'm a big semaglutide proponent after being on it for a year. I know research says it helps with inflammation, arthritis (separately from weight reduction), and all sorts of magical things. I lost 40 pounds in a year(230 to 190) at age 50. Great! I also went from being active and fat(weightlifting with some cardio) to basically having no energy. In the last year I've had arthritis appear in several joints. I'm awake…

Try Tirzepatide or one of the other drugs. They each have their own side effect profile.

Re: Semaglutide linked to lower predicted dementia risk

#183

Post by kulahan »

brazukadev wrote: post #162
eastbound wrote: post #134

Earlier quoted context omitted.

You say force a diet change on a patient. OP certainly meant forcing a diet change in the input of American factories. Sugar can be found in fruits. That's the right place. If you need some, use fruits, maybe alcohol. Everything else can be slashed. No sugar in prepared meals anymore. No sugar in pasta anymore. And most of all, no sugar in water. Sugar input makes more damage than cocaine today. We can call it the Pr…

people are so addicted to sugar that you are getting downvoted and maybe even flagged. I like "The War on Sugar" idea (even tho I went out 1 hour ago to buy lots of chocolates and candies, as I'm an addict).

I think it’s more because it’s kind of a strange rambling rant? He didn’t make any good points, he just made an analogy between it and alcohol prohibition like 7 times. He didn’t even bother to bring the idea home in the end, he just left it free-floating there. It’s just not a great comment.

Re: Semaglutide linked to lower predicted dementia risk

#184

Post by clipsy »

siva7 wrote: post #91
clipsy wrote: post #87

Earlier quoted context omitted.

If you're seriously claiming black women didn't have the right to vote in 1976, you should probably provide some evidence rather than snide remarks.

Then teach us.. when did they got actual voting rights? (i'm not trying to be snarky but sometimes it' not easy seeing the level of history ignorance in society)

I can't help but notice that you're still providing absolutely no evidence for an extraordinary claim.

Re: Semaglutide linked to lower predicted dementia risk

#185

Post by NorthSouthNorth »

SubmarineClub wrote: post #167
OptionOfT wrote: post #158

Earlier quoted context omitted.

We're too soft on companies, but equally too hard on people who have a food addiction.

[flagged]

I think this is easy to say as a healthy eater (I am one too, always have been). However, unlearning a lifetime of bad habits is hard. But yeah, it's costing nations billions that could be better spent.

Re: Semaglutide linked to lower predicted dementia risk

#186

Post by perching_aix »

bariswheel wrote: post #48

tdlr: This is a Novo Nordisk-funded study focusing on predictive biomarkers rather than real-world dementia cases. Novo Nordisk's actual dedicated clinical trials for Alzheimer's completely failed to show that semaglutide stops cognitive decline. "A predictive biomarker is like a "check engine" light on your dashboard. It warns you that there is a risk of a future problem. In this study, the researchers only checked…

So translated to human, does this basically mean then that semaglutide distorts dementia-predictions by altering the related biomarkers, rather than actually help with dementia?

Re: Semaglutide linked to lower predicted dementia risk

#187

Post by NorthSouthNorth »

kccqzy wrote: post #92
01100011 wrote: post #38

I'm a big semaglutide proponent after being on it for a year. I know research says it helps with inflammation, arthritis (separately from weight reduction), and all sorts of magical things. I lost 40 pounds in a year(230 to 190) at age 50. Great! I also went from being active and fat(weightlifting with some cardio) to basically having no energy. In the last year I've had arthritis appear in several joints. I'm awake…

I’m also active and fat. And to me being active is more important than losing weight; I’d rather continue to do those long 2000kcal bike rides on weekends than having a healthier BMI. I’ve heard stories of my own friends bonking during a ride and I decided that I wanted to err on the side of overeating. So semaglutide doesn’t interest me. You aren’t the only one I’ve heard who started to have no energy after being on…

People bonk because they're not eating enough DURING the ride. I'll eat (actually mostly drink) like 120-200g carbs on longer rides. Record is 700g during a 200km ride. I've seen big guys bonk too. It has very little to do with your BF% (although this is nuanced based on power zones and training 'durability' etc, etc).

Re: Semaglutide linked to lower predicted dementia risk

#188

Post by projektfu »

Retric wrote: post #161
bityard wrote: post #137

Earlier quoted context omitted.

The medical establishment that I have familiarity with (in the US) pretty much only ever treats symptoms, not causes. Don't believe me? Next time you go to see your primary care physician, ask them what you should be doing to lower your risk of whatever malady tends to run in your family. (Diabetes, cancer, dementia, etc.) They're going to stare at you in blank confusion for a few seconds before making some vague sug…

In my experience that’s wildly inaccurate. Dietary choices, weight loss, exercise, etc are often given as an effective means of avoiding and or controlling a wide range of conditions. People are instead blowing off such advice because they don’t want to hear it.

I never knew Kaiser Permanente was so "anti-establishment" but I get pages of recommendations for healthy eating and exercise every time I go and also randomly as part of my "Personal Action Plan".

Re: Semaglutide linked to lower predicted dementia risk

#189

Post by jaggederest »

Jaygles wrote: post #172
jaggederest wrote: post #117

Earlier quoted context omitted.

Speaking as someone who had the same kind of reservations, I think you sound exactly like me, and if I had any advice to my past self, it would be "get on it as early as it's available, start much lower than anyone thinks is sane, and never ever stop". I got a concierge doctor who absolutely evaluates what I ask for skeptically, and pay for my GLP medications out of pocket, so I feel ethically totally comfortable wit…

What downsides have you experienced?

Gastrointestinal - nausea, extreme fullness, paradoxically both rapid and slow transit (I recommend lots of fiber, but that will make you too full too), bloating, all kinds of negative stuff, and obviously if you're on a calorie deficit because you get full off a single bite of food you're going to have low energy and feel pretty garbage on that front (thus ramp slowly), but also some jitteryness, all manner of things. I would call the first week on a tiny dose something like a very mild GI bug or flu, in terms of everything I experienced.

That said, I'm extremely prone to side effects, most people I know who have tried them started at maybe half the standard dose and had zero side effects at all. I'm the best possible guinea pig for these things, because if I can tolerate it, almost anyone who isn't frankly allergic or something can.

The other downside, obviously, is injections - you will need to learn how to use sterile technique to inject yourself or pay the incredibly high costs for the pens. The pills are also an option but I have no personal experience and their bioavailability is so low I don't know that I fully trust them.

They will completely change your relationship with food and alcohol, too. Your tastes will probably shift, nearly everybody I know who is on them has essentially given up booze (maybe a couple drinks a year, more or less)

Re: Semaglutide linked to lower predicted dementia risk

#190

Post by ShinyLeftPad »

paulpauper wrote: post #144
fkdupman wrote: post #131

Reading about GLP-1 medications reminds me of the movie Limitless. Being on them sounds great, getting off of them not so much.

not really. these drugs only merely make you not overweight or obese, which was normal until around 1980 or so.

The study implies it also does other stuff though. That's the thing
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