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Semaglutide linked to lower predicted dementia risk

alz-journals.onlinelibrary.wiley.com

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Re: Semaglutide linked to lower predicted dementia risk

#81

Post by jambalaya8 »

dbalatero wrote: post #78
WalterBright wrote: post #70

Earlier quoted context omitted.

I don't buy that. You can buy a steak and a potato for two for less than a bag of Doritos. A banana costs far less than a candy bar. A bag of mixed nuts will provide many meals. Price out a bag of rice, a bag of beans, etc. > food companies' only interest is in maximizing profit Pleasing your customers is how profit is maximized. Besides, I bet if you were faced with two stores, one that charges $x for A, and another…

Where are you getting a steak and potato for 2 for less than a bag of Doritos? Is it a 50 lb bag of Doritos?

Maybe it's 4oz of very lean tough steak and a single small russet potato with no fat, and the two mentioned are five year olds.

Re: Semaglutide linked to lower predicted dementia risk

#82

Post by tiahura »

bariswheel wrote: post #48

tdlr: This is a Novo Nordisk-funded study focusing on predictive biomarkers rather than real-world dementia cases. Novo Nordisk's actual dedicated clinical trials for Alzheimer's completely failed to show that semaglutide stops cognitive decline. "A predictive biomarker is like a "check engine" light on your dashboard. It warns you that there is a risk of a future problem. In this study, the researchers only checked…

Doesn’t socialized medicine mean that big brother already knows the answer to these questions? Why isn’t NHS or whomever more useful on these issues?

Re: Semaglutide linked to lower predicted dementia risk

#83

Post by dev_l1x_be »

bariswheel wrote: post #48

tdlr: This is a Novo Nordisk-funded study focusing on predictive biomarkers rather than real-world dementia cases. Novo Nordisk's actual dedicated clinical trials for Alzheimer's completely failed to show that semaglutide stops cognitive decline. "A predictive biomarker is like a "check engine" light on your dashboard. It warns you that there is a risk of a future problem. In this study, the researchers only checked…

Not only that but high intakes of added sugars and fast-acting, high-glycemic carbohydrates are linked to an increased risk of cognitive decline and dementia. Excess simple sugars, particularly fructose and sucrose, promote insulin resistance, chronic inflammation, and vascular damage that impair brain function and accelerate neurodegeneration. So with other words, you diet is a major contributing factor here. The medical establishment and big pharma simple ignores the fact that the biggest health risk for a human being is the "modern" high sugar diet that Kellogs introduced in the US and spread to the western world (even to Asia at some extent).

Re: Semaglutide linked to lower predicted dementia risk

#84

Post by tiahura »

WarmWash wrote: post #67
Aurornis wrote: post #50

Earlier quoted context omitted.

That is the question now. Some studies have some early evidence that GLP-1s might reduce inflammation markers a little more than weight loss alone. Giving GLP-1s to normal weight people doesn’t work well because they can have to work harder to maintain their weight. That can be a real problem as people get older where maintaining muscle mass is important for quality of life and longevity. I remember how hard it was t…

My assumption was that GLP-1's don't suppress appetite so much as suppress the compulsion to eat when not necessary/more than necessary?

It’s both. That’s why it’s so effective.

Re: Semaglutide linked to lower predicted dementia risk

#85

Post by hinkley »

roryirvine wrote: post #5
randycupertino wrote: post #2

This is interesting. Diabetes is a well-known risk factor for dementia.

As is being sedentary - there are probably lots of interconnected factors in play, and GLP-1 receptor agonists seem to help with more than one (perhaps even many) of them. Unpicking the exact chains of causation is likely going to be extremely complex, but the general picture continues to look good.

We should probably be studying people who wear smart watches and collecting the activity levels to control for that.

But if GLP-1 makes you more active, who am I to complain. There's the reason they approve stomach stapling surgeries on morbidly obese people. They are so compromised that anything that gives them a chance to be more active offsets some of the risks of surgery, and the risks of inaction.

Re: Semaglutide linked to lower predicted dementia risk

#87

Post by clipsy »

siva7 wrote: post #66
kbelder wrote: post #62

Earlier quoted context omitted.

>50 years ago women didn't have voting rights Where are you? In the US, women have had full voting rights for over 100 years.

No, black woman (among many other minorities) certainly didn't. I guess that part isn't taught in american schools as thoroughly as it should be.

If you're seriously claiming black women didn't have the right to vote in 1976, you should probably provide some evidence rather than snide remarks.

Re: Semaglutide linked to lower predicted dementia risk

#88

Post by p_j_w »

hattmall wrote: post #42
object-a wrote: post #36

Earlier quoted context omitted.

What should public health have done differently?

Treat junk food like cigarettes

People have tried. Any time the government tries to do anything a substantial portion of the electorate throws a childish hissy fit and tries to make out that the Bolsheviks are coming to make their fries less tasty for no good reason.

Re: Semaglutide linked to lower predicted dementia risk

#89

Post by ChuckMcM »

bariswheel wrote: post #48

tdlr: This is a Novo Nordisk-funded study focusing on predictive biomarkers rather than real-world dementia cases. Novo Nordisk's actual dedicated clinical trials for Alzheimer's completely failed to show that semaglutide stops cognitive decline. "A predictive biomarker is like a "check engine" light on your dashboard. It warns you that there is a risk of a future problem. In this study, the researchers only checked…

Which sort of affirms the mantra, "If you can't prove causation, try to prove correlation." This because you can market correlation to unsophisticated readers and imply causation.

Re: Semaglutide linked to lower predicted dementia risk

#90

Post by phil21 »

kwanbix wrote: post #52
londons_explore wrote: post #23

So has anyone managed to separate the effects of semaglutide from the effects of weight loss? If this is caused by the weight loss, it is a little disappointing that public health didn't act quicker - lots of people have been overweight for a century now, so literally 10's of millions of people could have been saved from dementia had action been taken 100 years ago.

Well, if you consider that is much cheaper to eat trash than healthy, and that food companies' only interest is in maximizing profit, you have what we have.

I don’t consider that since it’s simply not true.

When I grew up relatively poor we never ate out or ate junk food because it is ridiculously expensive in comparison. We made our food from cheap ingredients. To save money.

Yes it takes more time and is far more work and is less convenient. US society has valued convenience over everything else for a few generations now. Cheaper it is not.

And it holds true today with my own grocery shopping. Cooking meals and being smart about grocery shopping is far cheaper per meal than buying premade junk. The few times I do have a cart full of products from the middle aisles I am astounded at how expensive it is.

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