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Semaglutide linked to lower predicted dementia risk

alz-journals.onlinelibrary.wiley.com

1–10 of 430 posts

Re: Semaglutide linked to lower predicted dementia risk

#4

This is interesting. Diabetes is a well-known risk factor for dementia.

Western disease and sugar heavy diets broadly speaking, which Semaglutide is a countermeasure against. Not yet a vaccine, but in due time (probably via gene therapy). Fructose also helps cancer metastases and spread.

https://www.sciencealert.com/common-sugar-appears-to-loosen-...

Re: Semaglutide linked to lower predicted dementia risk

#5

This is interesting. Diabetes is a well-known risk factor for dementia.

As is being sedentary - there are probably lots of interconnected factors in play, and GLP-1 receptor agonists seem to help with more than one (perhaps even many) of them.

Unpicking the exact chains of causation is likely going to be extremely complex, but the general picture continues to look good.

Re: Semaglutide linked to lower predicted dementia risk

#6

This is interesting. Diabetes is a well-known risk factor for dementia.

As is being sedentary - there are probably lots of interconnected factors in play, and GLP-1 receptor agonists seem to help with more than one (perhaps even many) of them. Unpicking the exact chains of causation is likely going to be extremely complex, but the general picture continues to look good.

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Re: Semaglutide linked to lower predicted dementia risk

#7
post #3

We are very early in the semaglutide world, exciting times ahead!

For sure we still need to find out many related outcomes.

Last year it become known that it increases (high relative risk, low absolute risk) non-arteritic anterior ischemic optic neuropathy (NAION), ie sudden, sometimes permanent vision loss.

https://www.ema.europa.eu/en/news/prac-concludes-eye-conditi...

Re: Semaglutide linked to lower predicted dementia risk

#8
"Semaglutide attenuates a proteomics-based dementia risk signature "

ie : clinically meaningless.

The company behind this, Novo Nordisk is increasingly desperate, as tirzepatide destroys the semaglutide revenue stream and the consequent job losses decimate the company

Re: Semaglutide linked to lower predicted dementia risk

#9

This is interesting. Diabetes is a well-known risk factor for dementia.

Western disease and sugar heavy diets broadly speaking, which Semaglutide is a countermeasure against. Not yet a vaccine, but in due time (probably via gene therapy). Fructose also helps cancer metastases and spread. https://www.sciencealert.com/common-sugar-appears-to-loosen-...

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Re: Semaglutide linked to lower predicted dementia risk

#10

Earlier quoted context omitted.

Western disease and sugar heavy diets broadly speaking, which Semaglutide is a countermeasure against. Not yet a vaccine, but in due time (probably via gene therapy). Fructose also helps cancer metastases and spread. https://www.sciencealert.com/common-sugar-appears-to-loosen-...

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Just pattern matching as an autistic human. Similar results were seen on a ketogenic diet (and to some extent, intermittent fasting). What do they have in common? Sugar intake reduction. Is it surprising sugar potentially fuels cancer, contributes to dementia, etc? It shouldn’t be. It’s indirect and a casual connection.

There is no health benefit to a high sugar or Western diet, only downside. I think calling it poison is hyperbole, but it’s definitely not healthy, based on all available evidence. I expect to see longitudinal scale results over the next decade as everyone starts taking GLP-1s.

(I take a glp-1, they’re an amazing drug class, it changes how your brain operates, charlie day waving arms in front of a whiteboard meme here)

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