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How to sequence your own DNA at home

bradleywoolf.com

31–40 of 161 posts

Re: How to sequence your own DNA at home

#31

I've bee thinking about starting a company where I fish roots out of your sewer and identify the plant (by sequence if necessary) that you have to kill so your sewer doesn't collapse as soon as it otherwise would. $100 to stave off that $10000 sewer replacement for a few years would be worth it to a lot of people

Hard to get a plumber to knock on my door for under $100. Maybe you mean $500? Or is it $100 for the lab bit only?

Re: How to sequence your own DNA at home

#34

I've bee thinking about starting a company where I fish roots out of your sewer and identify the plant (by sequence if necessary) that you have to kill so your sewer doesn't collapse as soon as it otherwise would. $100 to stave off that $10000 sewer replacement for a few years would be worth it to a lot of people

That’s a really clever idea, I would definitely pay for that in the right circumstances.

Now that I think about it - could you just pour some sort of biodegradable broad-spectrum herbicide down the drain to get the same effect for cheaper?

Re: How to sequence your own DNA at home

#35
post #18

> This is intended to be read by AI Fuck this

Man, doctors thought they had it bad before. For just a six yards I can play Peter Thiel at home! $6k invested so I can set an AI in YOLO mode to tell me I have some hyper-specific version of kennel cough? “But that occurs in dogs?” “You’re right. Let me look into actual gene sequencing instead of just guessing. I think the N is the load bearing letter.”

Funniest thing I read today, thank you!

Re: How to sequence your own DNA at home

#36
post #31

I've bee thinking about starting a company where I fish roots out of your sewer and identify the plant (by sequence if necessary) that you have to kill so your sewer doesn't collapse as soon as it otherwise would. $100 to stave off that $10000 sewer replacement for a few years would be worth it to a lot of people

Hard to get a plumber to knock on my door for under $100. Maybe you mean $500? Or is it $100 for the lab bit only?

Well if you have this problem, then having the plumber over is a sunk cost. You're paying them regularly to clear the sewer, and their snake will come back with root matter in the bit. Put that sample in a zip-lock bag and call me. I'll come over, take the sample, and identify the plants near your sewer line. If I get a match, I'll sell that info to you for $100.

Once I figure out how to make it work at all, I'll build a network of plant nerds and teach them to do the same in their cities, and pivot to providing lab services and training for them. Much of the time no sequencing will be required, just a microscope and knowledge of what's growing nearby. But if they have more than one plant of the same species, sequencing will be necessary.

Fingers crossed they're not clones, though I suppose I could do lab testing for that as well, and then I maybe you'd have to kill multiple just to be sure you got the one. In that case, hopefully I'd have at least narrowed it down for you. Probably would just deny the job if the odd of being helpful are low, like if you have 50 clones of the same tree all growing along your sewer line, then I can't help you, it's time to start saving for a liner or a replacement.

It's like uber, but for shit-covered roots.

Re: How to sequence your own DNA at home

#37

I've bee thinking about starting a company where I fish roots out of your sewer and identify the plant (by sequence if necessary) that you have to kill so your sewer doesn't collapse as soon as it otherwise would. $100 to stave off that $10000 sewer replacement for a few years would be worth it to a lot of people

That’s a really clever idea, I would definitely pay for that in the right circumstances. Now that I think about it - could you just pour some sort of biodegradable broad-spectrum herbicide down the drain to get the same effect for cheaper?

This is precisely what I do each year with a product designed for this exact purpose. $8+shipping gets me enough for my annual pipe maintenance. It's even the special kind because I have clay pipes.

I don't wasn't to kill parents idea. It's neat, and Im sure there's use cases that my solution doesn't meet

Re: How to sequence your own DNA at home

#38
post #21

one main marketing leverage of 23andMe, AncestryDNA, etc are fulfilling the curiosity of people who want to know which part of the world their genes are from. I guess that dataset should be preparatory.

Problem with those providers - they only check 700K positions out of 3 billion and there is no mapping quality or allelic depth data in those dataset and this is critical for assessing whether the detected variant is a false positive or real.

It's not suitable for health investigations since most of DNA is not sequenced and genotyping technology is known to produce high rate of false positive for rare mutations.

(I'm the solo-founder of Gene Inspector Pro, mentioned in the blog post). AMA. :)

Re: How to sequence your own DNA at home

#40
post #16
post #15

Earlier quoted context omitted.

I suspect there is a deep sequencing service that is non CLIA and cheap. True. they may not be trustworthy with the data. That said, there are steps here where the data is put into Claude. Do we trust that ?

I would never trust that. Instead I would use Claude to teach me genomics and build the tools to process and interpret data locally

It's not impossible: Claude can take care of bioinformatics part. But to understand genetics and cellular biology you need a knowledge foundation first.

Unless you just want it on a level "Does this mutation leads to a genetic disorder X" - this is a simple way to put it, but not enough to actually understand genetics.

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