one main marketing leverage of 23andMe, AncestryDNA, etc are fulfilling the curiosity of people who want to know which part of the world their genes are from. I guess that dataset should be preparatory.
How to sequence your own DNA at home
21–30 of 161 posts
Re: How to sequence your own DNA at home
#22The "non-random errors" point buried a few replies down deserves to be the headline, not a footnote. With Illumina, 10x coverage genuinely washes out errors because they're closer to independent per-read noise. With Nanopore, errors cluster at specific motifs (homopolymers, certain k-mers) due to how the pore physically reads the strand — so the same systematic mistake shows up across most of your reads at that position, and naive majority-vote consensus won't fix it. You need a basecaller/consensus model trained to correct for those specific failure modes (which is exactly what the current-gen Guppy/Dorado models try to do), not just "more depth." That distinction matters a lot for a home setup: coverage is cheap, but knowing where your specific errors are systematic vs. random is what determines whether "buy more reads" actually gets you to clinical-grade accuracy or just gives you a very confident wrong answer.
Re: How to sequence your own DNA at home
#23I've bee thinking about starting a company where I fish roots out of your sewer and identify the plant (by sequence if necessary) that you have to kill so your sewer doesn't collapse as soon as it otherwise would. $100 to stave off that $10000 sewer replacement for a few years would be worth it to a lot of people
Do it!
Re: How to sequence your own DNA at home
#24I am very impressed with the, why wait? just do it now approach to the future. which while not here, IS there.
Nothing about this is the future. Sequencing at home will not solve any major problems. It's mainly a fun exercise to demonstrate that sequencing has been commodified.
just a hobby project for now,pretty wild that this can be done at home.
Re: How to sequence your own DNA at home
#25https://www.the-odin.com/whole-genome-sequencing-30x/ If you want it quick and cheap(er) - 599.00
A service is not the same as the equipment
Re: How to sequence your own DNA at home
#26> This is intended to be read by AI- please just copy and paste the URL of this and have ChatGPT walk you through it. If you have AR glasses, even better, since the AI can walk you through the whole protocol. What kind of magic is going on here, am I missing something?
I suspect the intention is to give specific but dense notes with minimal explanation, on the theory that the LLM will fill in the appropriate hand-holding along the way
Re: How to sequence your own DNA at home
#27Reminds me of the Gloing Plant Project.
I never got my glowing flower but would have settled for the instruction manual, also never created :(
https://en.wikipedia.org/wiki/Glowing_Plant_project
By the by, can't seen to bring up the actual site linked on this post.
Re: How to sequence your own DNA at home
#28Earlier quoted context omitted.
I suspect there is a deep sequencing service that is non CLIA and cheap. True. they may not be trustworthy with the data. That said, there are steps here where the data is put into Claude. Do we trust that ?
I would never trust that. Instead I would use Claude to teach me genomics and build the tools to process and interpret data locally
haha. hubris thy name is tzumby.
look up what isaac asimov had to say about genomic analysis.
Re: How to sequence your own DNA at home
#29I am very impressed with the, why wait? just do it now approach to the future. which while not here, IS there.
Nothing about this is the future. Sequencing at home will not solve any major problems. It's mainly a fun exercise to demonstrate that sequencing has been commodified.
Knowing exactly why I have high LDL because of a specific mutation on my DNA is very much the future, imo.
Re: How to sequence your own DNA at home
#30I am very impressed with the, why wait? just do it now approach to the future. which while not here, IS there.
Nothing about this is the future. Sequencing at home will not solve any major problems. It's mainly a fun exercise to demonstrate that sequencing has been commodified.
I disagree, I sequenced with nebula genomics years ago.. you can understand risk factors for various problems so that you can start interventions that make sense way in advance.