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Should DayQuil Be Legal?

theargumentmag.com

211–220 of 322 posts

Re: Should DayQuil Be Legal?

#211

It should be legal. Caveat Emptor applies always. to everything. I'd rather have choices available in a marketplace rather than a nanny state stifling innovation through its own incompetence.

With computerized registers and loyalty programs, it is way too easy to profile. I am not too worried about looking like I chug too much aspirin; it's the further out assumptions or speculations that models (like I myself once designed or otherwise) might make that I worry about, that would not require proof, and would not be documented somewhere. I mean there is also stuff "like" congestion pricing to worry about, and maybe that would work better to make people think about liberties and tech. Dunno.

Re: Should DayQuil Be Legal?

#212

The article kinda glossed over it, but one fact under-appreciated by the general public is just how dangerous acetaminophen overdoses can be . Scientists often talk about the "therapeutic index" or "safety ratio" of a drug. It's the LD50 (dose at which 50% of recipients die) divided by the effective dose. Common hard drugs like heroin or methamphetamine have a safety ratio of about 6-10 [1]. "Soft" drugs like marijua…

[flagged]

LD50 is around 30mg/kg which is an absolute monster amount. Dosages of over 5000x the dose to get "high" have been tested.

At those levels, you'd be dealing with other intense effects before you'd drop dead.

Iversen, L. L. The Science of Marijuana / Leslie L. Iversen. Oxford University Press, 2000.

Re: Should DayQuil Be Legal?

#213

Earlier quoted context omitted.

[flagged]

Dude, chill out. Everything has a fatal dose, you can literally look up the LD50 and find that it’s a big number. Nobody is coming for your weed.

To be fair, a lot of governments and pearl-clutchers actually are coming for your weed.

Re: Should DayQuil Be Legal?

#214

Earlier quoted context omitted.

> As the person holding the money, it's my job to look at what is effective and what the active ingredients are in any given product That ignores over a century of law regarding drug safety and efficacy, and false advertising.

Not to mention it ignores reality. Most consumers have neither the time now knowledge to research everything they buy. That's one of the roles of government.

That's one of the important reasons - I thought - that we have the FDA in the first place. But these days I'm really not so sure. So many promising treatments rejected (or just stalled forever) while pointless placebos and worse get or remain approved.

So - why again does the FDA exist?

Re: Should DayQuil Be Legal?

#215

The article kinda glossed over it, but one fact under-appreciated by the general public is just how dangerous acetaminophen overdoses can be . Scientists often talk about the "therapeutic index" or "safety ratio" of a drug. It's the LD50 (dose at which 50% of recipients die) divided by the effective dose. Common hard drugs like heroin or methamphetamine have a safety ratio of about 6-10 [1]. "Soft" drugs like marijua…

I'm grateful for you mentioning this. I grew up with ibuprofen as my default painkiller without really thinking of it too much but am about to do PRP which requires no NSAIDs for a week prior and 3 months after - but they do allow/recommend Tylenol as an alternative, especially for the post-procedure pain. I just would've assumed it was a sufficiently good substitute that I could treat them equivalently but now i kno…

Nsaids are dangerous in all sorts of other ways, kidney, gut lining. Pain medications that work and are safe seem to all be highly addictive.

Re: Should DayQuil Be Legal?

#216

Earlier quoted context omitted.

Dude, chill out. Everything has a fatal dose, you can literally look up the LD50 and find that it’s a big number. Nobody is coming for your weed.

I think the thing is that there is no official accepted value of LD50 for THC since there has never been a recorded death from THC: > The median lethal dose (LD50) of THC has been determined in various animal species through oral administration and ranges from 800 to 9000 mg/kg. In humans, there have been no recorded instances of fatal overdoses resulting from acute THC use. However, estimates for a potentially letha…

It's not true that there has never been a recorded death from THC. A quick literature search turned up:

B. Hartung, S. Kauferstein, S. Ritz-Timme, T. Daldrup, Sudden unexpected death under acute influence of cannabis, Forensic Science International (2014), http://dx.doi.org/10.1016/j.forsciint.2014.02.001. Case report of two otherwise-healthy 20-something men who died of cardiac arrhythmia's following large marijuana doses.

https://3402974.fs1.hubspotusercontent-na1.net/hubfs/3402974...

Noble, M. J., Hedberg, K., & Hendrickson, R. G. (2019). Acute cannabis toxicity. Clinical Toxicology, 57(8), 735–742. https://doi.org/10.1080/15563650.2018.1548708. Clinical review of 253 Poison Center cases involving acute cannabis poisoning; 8 patients were admitted to the ICU, 3 were intubated, and 1 died.

https://pubmed.ncbi.nlm.nih.gov/30676820/

There's also a Heyndrickx 1969 paper that everybody cites (including my original reference on hazard ratios), but I can't find an abstract or full text anywhere on the web.

Cases of cannabis poisoning fatalities are extremely rare, but they do exist. Your citation was apparently unaware of (or possibly published before) the other cases.

Re: Should DayQuil Be Legal?

#217
I'm not sure what it is in the Dayquil - the DXM or the "decongestant," but there is a stimulant effect that is half of what I buy it for. It is the most effective medication I have found for getting me off the couch and able to power through a workday with a moderate cold, and definitely does something that Acetaminophen alone doesn't do.

Re: Should DayQuil Be Legal?

#218

The article kinda glossed over it, but one fact under-appreciated by the general public is just how dangerous acetaminophen overdoses can be . Scientists often talk about the "therapeutic index" or "safety ratio" of a drug. It's the LD50 (dose at which 50% of recipients die) divided by the effective dose. Common hard drugs like heroin or methamphetamine have a safety ratio of about 6-10 [1]. "Soft" drugs like marijua…

Safety ratio as you present it is a bit misleading, numbers for hard/soft drugs are usually for a single dose.

Re: Should DayQuil Be Legal?

#219
post #169

Earlier quoted context omitted.

Indeed. I like beer quite a lot and have for a very long time, so acetaminophen is banned from my medicine cabinet.

Seems like the logical thing to ban from your stomach for the time periods you need acetaminophen is the beer, unless I'm missing something.

Alcoholism, you're missing alcoholism.

Re: Should DayQuil Be Legal?

#220

The article kinda glossed over it, but one fact under-appreciated by the general public is just how dangerous acetaminophen overdoses can be . Scientists often talk about the "therapeutic index" or "safety ratio" of a drug. It's the LD50 (dose at which 50% of recipients die) divided by the effective dose. Common hard drugs like heroin or methamphetamine have a safety ratio of about 6-10 [1]. "Soft" drugs like marijua…

It's a good darwin effect clearer/cleaner I think.

Can't read or follow simple instructions? Well maybe modern society is not for you anymore.

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