Earlier quoted context omitted.
An interesting new drug is Auvelity, where Dextromethorphan is proposed to help stimulate neurotropic growth factor to help the brain repair itself, and similar related drugs like dextromethorphan and ketamine and other NMDA receptor antagonists are innovative drugs to help prevent Alzheimer's.
Haven't heard of Alzheimer's. What kind of use is necessary ? I would assume something like an ultra low dose but daily thing ?
Should DayQuil Be Legal?
151–160 of 322 posts
Re: Should DayQuil Be Legal?
#152> Historically, Sudafed has contained pseudoephedrine, the wonder drug equally good at clearing congestion and making crystal meth.
It's much better at clearing congestion than at making crystal meth. And, as the joke goes, it's easier to make an effective decongestant from meth than it is to buy it from a store.
Re: Should DayQuil Be Legal?
#153This article uses the trick where you pick studies that support your argument and ignore all of the studies that disagree with it. There are other studies where Dextromethorphan improves both objective and subjective measures of coughing: https://pubmed.ncbi.nlm.nih.gov/37232330/ They also picked a study that shows honey outperforming Dextromethorphan but ignored all the studies that show honey performing similarly o…
Isn't it a bad sign that there are such varied results? Perhaps that's only a bad sign for the state of science, but I suspect it's also a bad sign for the effectiveness of the drug.
Re: Should DayQuil Be Legal?
#154The article kinda glossed over it, but one fact under-appreciated by the general public is just how dangerous acetaminophen overdoses can be . Scientists often talk about the "therapeutic index" or "safety ratio" of a drug. It's the LD50 (dose at which 50% of recipients die) divided by the effective dose. Common hard drugs like heroin or methamphetamine have a safety ratio of about 6-10 [1]. "Soft" drugs like marijua…
I didn’t know this until recently either. I grew up on a family where if there was pain, you just take tylenol to deal with it. We always followed the dosage timing and never had issues. So recently when my wife had some chronic pain I suggested taking tylenol but even after two days the pain would not go away and she went to ER. They did a blood check to see if they could find anything. They didn’t find the cause, j…
Not to chastise you or your wife, there is an actual "Liver Warning" on Tylenol Product labels. They warn against 4000mg/day or with alcohol consumption. It's not an on/off switch, the damage occurs on a ramp that achieves a critical point after so much consumption.
Saying this to encourage label reading and to refute those who might try to characterize your wife's experience as anecdotal. And for those who stop reading a page like this one, after the first paragraph that touts "no evidence": https://www.tylenolprofessional.com/safety-and-efficacy/safe... when at the bottom it reveals the Liver Warning.
Re: Should DayQuil Be Legal?
#155It should be legal. Caveat Emptor applies always. to everything. I'd rather have choices available in a marketplace rather than a nanny state stifling innovation through its own incompetence.
Re: Should DayQuil Be Legal?
#156Earlier quoted context omitted.
It's funny that TFA seems to use the comparison to honey as disparagement, rather than interpret the same information as an endorsement of the helpfulness of honey.
I think the point is honey is known as a home remedy, may already be in your house and is available at a much lower price (farmer’s markets and woo merchants possibly excepted).
Honey is also well established in medicine, especially in wound and infection management. I'm not sure of how much clinical evidence supports cough suppression, but it not huge leap to suspect that it could be a second order effect of its antibacterial properties, like in bacterial bronchitis.
Re: Should DayQuil Be Legal?
#157The article kinda glossed over it, but one fact under-appreciated by the general public is just how dangerous acetaminophen overdoses can be . Scientists often talk about the "therapeutic index" or "safety ratio" of a drug. It's the LD50 (dose at which 50% of recipients die) divided by the effective dose. Common hard drugs like heroin or methamphetamine have a safety ratio of about 6-10 [1]. "Soft" drugs like marijua…
Ibuprofen isn’t much better, unfortunately.
Re: Should DayQuil Be Legal?
#158Dextromethorphan is abused to get high. Not sure how it could be a placebo.
Re: Should DayQuil Be Legal?
#159The article kinda glossed over it, but one fact under-appreciated by the general public is just how dangerous acetaminophen overdoses can be . Scientists often talk about the "therapeutic index" or "safety ratio" of a drug. It's the LD50 (dose at which 50% of recipients die) divided by the effective dose. Common hard drugs like heroin or methamphetamine have a safety ratio of about 6-10 [1]. "Soft" drugs like marijua…
Ibuprofen isn’t much better, unfortunately.
The index for ibuprofen is waaaaay better than DayQuil
Re: Should DayQuil Be Legal?
#160This article uses the trick where you pick studies that support your argument and ignore all of the studies that disagree with it. There are other studies where Dextromethorphan improves both objective and subjective measures of coughing: https://pubmed.ncbi.nlm.nih.gov/37232330/ They also picked a study that shows honey outperforming Dextromethorphan but ignored all the studies that show honey performing similarly o…
In my subjective experience, Dextromethorphan (DXM, as the robo-trippers call it) does almost nothing for me, in the 1-5% range The only cold and cough medicine that really truly works is the over-the-counter stuff, pseudoephedrine, works amazing for me. I usually pick up a box of the stuff when school starts in the fall and I go through half a box of it by the following summer.
Pseudoephedrine is a decongestant to relieve the nasal/sinus congestion.
If it helps with your coughing, it’s because it’s stopping the postnasal drip, not suppressing the cough as DXM would by shutting down the cough reflex.
Two different, but very similar use cases. DXM is a god-send in the appropriate time.