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Cannabis users face substantially higher risk of heart attack (2025)

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Re: Cannabis users face substantially higher risk of heart attack (2025)

#41

Post by kranner »

embedding-shape wrote: post #5

> researchers were unable to account for several potential confounding factors including the duration and amount of cannabis use or the use of tobacco or other drugs. Personally I'd wager a bet it's the tobacco and/or smoking that is the harmful part, but it kind of dumbfounds me they failed to account for "details" like "duration and amount of cannabis use", that feels like a very vital thing to control for. Nothing…

Edible forms of cannabis raise heart rate and blood pressure substantially as well.

Re: Cannabis users face substantially higher risk of heart attack (2025)

#42

Post by Noaidi »

sandcat_ wrote: post #8

Not really related, but the other thing I found out recently that cannabis can cause is the worst panic attack I have ever experienced: a DPDR (derealization / depersonalization) panic attack. I’ve had regular panic attacks before. I get one a year, roughly, where I get essentially heart attack symptoms. But this was something else. It felt like something was truly, irrevocably broken with my mind and I couldn’t even…

THC increases glutamate release[1], which is most likely the source of this panic. I have psychotic episodes even with a a few big hits but then again I have schizoaffefctive disorder. Glutamate is my arch enemy.

[1] https://link.springer.com/article/10.1186/s42238-025-00277-9

Re: Cannabis users face substantially higher risk of heart attack (2025)

#43

Post by sscaryterry »

latexr wrote: post #17
embedding-shape wrote: post #5

> researchers were unable to account for several potential confounding factors including the duration and amount of cannabis use or the use of tobacco or other drugs. Personally I'd wager a bet it's the tobacco and/or smoking that is the harmful part, but it kind of dumbfounds me they failed to account for "details" like "duration and amount of cannabis use", that feels like a very vital thing to control for. Nothing…

> Nothing is good for you in too great amounts, even water https://youtube.com/watch?v=XewVicFzRxw&t=152s

Yep, https://en.wikipedia.org/wiki/Median_lethal_dose

Re: Cannabis users face substantially higher risk of heart attack (2025)

#44

Post by detourdog »

Dan_- wrote: post #15
embedding-shape wrote: post #5

> researchers were unable to account for several potential confounding factors including the duration and amount of cannabis use or the use of tobacco or other drugs. Personally I'd wager a bet it's the tobacco and/or smoking that is the harmful part, but it kind of dumbfounds me they failed to account for "details" like "duration and amount of cannabis use", that feels like a very vital thing to control for. Nothing…

Exactly. Being unable to account for this covariate (tobacco use) pretty much invalidates this analysis. The odds ratio for tobacco use is basically the same (3x). Also, title needs a 2025.

Not to mention cocaine.

Re: Cannabis users face substantially higher risk of heart attack (2025)

#45

Post by shevy-java »

What I find fascinating is how smokers rationalize their behaviour, e. g. "weed is harmless". When they compare it to fentanyl or heroine/cocaine, but compounds are never intrinsically harmless. But you can not get that message across most folks who are smoking weed. It's a somewhat similar issue, to some extent, when you look at sumo wrestlers. These have a significantly lower life expectancy on average than the rest of the society in Japan, but the sumo association does not acknowledge that. It's really strange how the human mind operates.

Re: Cannabis users face substantially higher risk of heart attack (2025)

#46

Post by ck2 »

block_dagger wrote: post #38
ck2 wrote: post #24

people just want their recreational drugs it's as stupid as smoking/vaping and not even black box warnings will get people to stop now if you need pain management I can respect that 100% but you need to investigate Palmitoylethanolamide and Geraniol as alternatives * https://news.ycombinator.com/item?id=48700498

Can you respect folks who are treating mental/emotional pain or just physical?

sure but you aren't going to help mental/emotional problems by getting stoned

there are far better, legal supplements to treat that anyway, less expensive too

dope activates AMPK in the brain/CNS and turns off AMPK in the body/heart it's an incredibly stupid thing to do to yourself (also why people get "the munchies")

literally why it's called dope (before dope meant "cool")

Re: Cannabis users face substantially higher risk of heart attack (2025)

#47

Post by yehosef »

Noaidi wrote: post #31
embedding-shape wrote: post #14

Earlier quoted context omitted.

Literally just wrote about that: https://news.ycombinator.com/item?id=48794178 > I've smoked cannabis daily for maybe 15 years [...] Visited a cardiologist like two months ago and have perfectly fine heart despite the smoking.

Many people have had cardiologists say they have perfectly fine hearts go on to have heart attacks months later. My brother was one of these people. He was going in for spinal surgery, cardio said his heart was fine. Two weeks after surgery he was short of breath. Turns out he needed a triple bypass. And that was a physical change. Heart attacks happen because of electrocardiac issues as well.

[flagged]

Re: Cannabis users face substantially higher risk of heart attack (2025)

#48

Post by pipes »

Noaidi wrote: post #31
embedding-shape wrote: post #14

Earlier quoted context omitted.

Literally just wrote about that: https://news.ycombinator.com/item?id=48794178 > I've smoked cannabis daily for maybe 15 years [...] Visited a cardiologist like two months ago and have perfectly fine heart despite the smoking.

Many people have had cardiologists say they have perfectly fine hearts go on to have heart attacks months later. My brother was one of these people. He was going in for spinal surgery, cardio said his heart was fine. Two weeks after surgery he was short of breath. Turns out he needed a triple bypass. And that was a physical change. Heart attacks happen because of electrocardiac issues as well.

Did you brother have a Coronary Artery Calcium score scan?

Re: Cannabis users face substantially higher risk of heart attack (2025)

#49

Post by [deleted] »

teekert wrote: post #27

I wonder about all the confounding effects. In my country (famous for cannabis to be easy to come by (for decades already), and I saw many smoke from age 16 up as I grew up in 90's, 00's). I have always felt that the heavy cannabis smokers had something to compensate; stress, unrest, impending depression, friction with parents. It was never the healthy sporty types with fulfilling relationships, good grades or a nice…

[deleted]

Re: Cannabis users face substantially higher risk of heart attack (2025)

#50

Post by detourdog »

KellyCriterion wrote: post #32
teekert wrote: post #27

I wonder about all the confounding effects. In my country (famous for cannabis to be easy to come by (for decades already), and I saw many smoke from age 16 up as I grew up in 90's, 00's). I have always felt that the heavy cannabis smokers had something to compensate; stress, unrest, impending depression, friction with parents. It was never the healthy sporty types with fulfilling relationships, good grades or a nice…

> stress, unrest, impending depression, friction with parents Well, Id guess these are reasons for any case of substance missuse?

I believe it’s an “artificial” reward mechanism for some people. The ability to control one’s own rewards is an easy habit to take up. If the rewards aren’t coming from externalities one needs to get them from somewhere.
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