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Frog-derived gut bacterium eradicates tumors in mice

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Re: Frog-derived gut bacterium eradicates tumors in mice

#51

We are destroying ecosystems so fast that there will be no frogs and we will regret it. The same with all the nature

We get what we deserve. We let the top 1% destroy our planet and also let them live the longest in their bunkers, while we deal with the repercussions of not having done enough. But I've noticed that folks on HN are very very fond of capitalism, so it's no point arguing against it on here and on the effects of wealth accumulation and greed.

people are very fond of it here -> there's no point arguing against it here?

Backwards logic. If they're fond of it then they're the people to be arguing against, no?

Re: Frog-derived gut bacterium eradicates tumors in mice

#52
Previus discussion (from the university press release) https://news.ycombinator.com/item?id=46306894 (498 points | 6 months ago | 140 comments) I'll rehash my comment

They used mice, because they are good for early tries. The researchers had 9 bacterias and only 1 was successful. Experiments in mice are cheaper and have less ethical problems than experiments in humans. (Hey! They even injected the cancer cells in mice and waited a week until it grow. Nobody will approve something like that in humans.)

The title claims that the tumos were eradicated. The title hides that it was a small tumor they injected in the mice and more importantly that it disappeared for two weeks until the experiment ended. It's difficult to guess if it will be useful for humans with bigger tumors because they are harder to detect, and it would work for a interesting enough period like 5 years.

There is also and old comment by octaane https://news.ycombinator.com/item?id=46308732 I'll quote it partially:

> Several things trigger my bullshit meter. Quote:

>> "This dramatically surpasses the therapeutic efficacy of current standard treatments, including immune checkpoint inhibitors (anti-PD-L1 antibody) and liposomal doxorubicin (chemotherapy agents)"

> PD-L1 monoclonal antibodies are only effective against cancers that are PD-L1 positive. [...] Many tumor types are not PD-l1 positive.

> Doxy is an ancient SOC chemo.

> [...]

Re: Frog-derived gut bacterium eradicates tumors in mice

#55
post #18

Earlier quoted context omitted.

~~I wouldn't be so sure about "clearly". We're still very squarely in the "fancy auto-complete" stage of "AI", the name of which I still consider more branding than reality.~~ Edit: Ignore me, I'm sleepy and can't read, lol

The person you’re replying to was being glib

Lol! Yep, that's my bad. Too sleepy right now.

Re: Frog-derived gut bacterium eradicates tumors in mice

#56
post #19

I wonder if animals have always seen frogs as unpleasant medicine they need to eat occasionally. My dog would happily scarf them down if I let him. Or does it have to be IV administered? Also who thinks -- "hmm we've found a new random bacteria --- let's give a bunch of tumors to mice and then IV inject this random thing into them!"? There must have been something about the microbe that gave them a hint. Maybe it's i…

> unpleasant

> happily

I think you answered your own question really, a lot of animals just enjoy eating them (humans included!)

Re: Frog-derived gut bacterium eradicates tumors in mice

#57

We are destroying ecosystems so fast that there will be no frogs and we will regret it. The same with all the nature

We get what we deserve. We let the top 1% destroy our planet and also let them live the longest in their bunkers, while we deal with the repercussions of not having done enough. But I've noticed that folks on HN are very very fond of capitalism, so it's no point arguing against it on here and on the effects of wealth accumulation and greed.

[deleted]

Re: Frog-derived gut bacterium eradicates tumors in mice

#58
post #18

Earlier quoted context omitted.

~~I wouldn't be so sure about "clearly". We're still very squarely in the "fancy auto-complete" stage of "AI", the name of which I still consider more branding than reality.~~ Edit: Ignore me, I'm sleepy and can't read, lol

How in the world did you miss such obvious sarcasm?

Whoops, lack of sleep, haha.

Re: Frog-derived gut bacterium eradicates tumors in mice

#60

We are destroying ecosystems so fast that there will be no frogs and we will regret it. The same with all the nature

We get what we deserve. We let the top 1% destroy our planet and also let them live the longest in their bunkers, while we deal with the repercussions of not having done enough. But I've noticed that folks on HN are very very fond of capitalism, so it's no point arguing against it on here and on the effects of wealth accumulation and greed.

Yeah, sure, capitalism, 1%, etc. Spoken like a 15yo who just saw some DSA- agitprop on TikTok and is now ready to solve the world's problems.
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