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That can't be good. Life cycle of a human egg is organized around preserving mitochondria to be as young and fresh as possible across generations. Using adult cell, even a stem cell to make an egg probably gives it mitochondrial damage that usually takes hundreds of human generations to accumulate.
That can't be good. Life cycle of a human egg is organized around preserving mitochondria to be as young and fresh as possible across generations. Using adult cell, even a stem cell to make an egg probably gives it mitochondrial damage that usually takes hundreds of human generations to accumulate.
Mitochondria can be translplanted/replaced. There already therapies and babies born out of these kinds of procedures
That can't be good. Life cycle of a human egg is organized around preserving mitochondria to be as young and fresh as possible across generations. Using adult cell, even a stem cell to make an egg probably gives it mitochondrial damage that usually takes hundreds of human generations to accumulate.
genuinely curious: how does any life still exist if this holds true?
Earlier quoted context omitted.
Mitochondria can be translplanted/replaced. There already therapies and babies born out of these kinds of procedures
Can you point me to anything about mitochondrial transplants? I'd love to see bat mitochondria transplanted into other mammals. They must have really superior ones given the energy expenditures needed to support flight and their long lifespans.
That can't be good. Life cycle of a human egg is organized around preserving mitochondria to be as young and fresh as possible across generations. Using adult cell, even a stem cell to make an egg probably gives it mitochondrial damage that usually takes hundreds of human generations to accumulate.
I wonder if you could coax cells from the testes back into stem cells to then re-specialize into ovarian cells.
Earlier quoted context omitted.
Mitochondria can be translplanted/replaced. There already therapies and babies born out of these kinds of procedures
Can you point me to anything about mitochondrial transplants? I'd love to see bat mitochondria transplanted into other mammals. They must have really superior ones given the energy expenditures needed to support flight and their long lifespans.
The origins of stem cells for use in the biosciences and in cosmetics are extremely brutal and should be illegal. Sandra Bullock explains it better than I could: https://youtu.be/PwO3TEj9-5g
Earlier quoted context omitted.
Mitochondria can be translplanted/replaced. There already therapies and babies born out of these kinds of procedures
Can you point me to anything about mitochondrial transplants? I'd love to see bat mitochondria transplanted into other mammals. They must have really superior ones given the energy expenditures needed to support flight and their long lifespans.
The reason is that genetics/evolution don't yet seem to fully explain how humans exist. A computer genetic algorithm run for a billion generations doesn't lead to anything anywhere near the the complexity of a human.
I suspect there are as-yet undiscovered effects which shape the next generation. Whether that be DNA methylation, gut bacteria passing from mother to child, selection of the 'correct' egg or sperm out of millions, or something new and un-discovered etc.
And if those effects are bypassed with artificial conception, we might end up with humans which aren't as strong, aren't as smart, aren't as well adapted to a changing environment, etc.
The effect will be small for each generation, but after 5-10 generations of a combination of artificial and natural conception you could end up with meaningful loss of fitness - or perhaps a lack of gain of fitness that would have otherwise occurred.