The first early human eggs from stem cells
conception.bio
The first early human eggs from stem cells
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Re: The first early human eggs from stem cells
#2Related (2021) Turning stem cells into human eggs (97 points, 102 comments) https://news.ycombinator.com/item?id=29040823
Re: The first early human eggs from stem cells
#3A japanese scientist again (Katsuhiko Hayashi is in Osaka).
Shinya Yamanaka created iPSPs in 2009:
https://en.wikipedia.org/wiki/Shinya_Yamanaka
Guess the japanese excel at micromanaging. Although one could say that the research here in the article is more epic than Shinya's discovery, but I remember having watched one of his presentation and it convinced me of pure epicness, if you understand how his team found the "Yamanaka factors". That was by human (work) consistency. About as epic as Christiane Nüsslein-Volhard and her mutant screens, that also involved tons of micro-experiments.
Re: The first early human eggs from stem cells
#4How hard you have to work to break scroll on web page?
Nice article, but going through it was a technical nightmare.
Can we stop adding unnecessary JS to website to stop global warming by calculating AND ALTERING SCROLL?
Re: The first early human eggs from stem cells
#5That can't be good. Life cycle of a human egg is organized around preserving mitochondria to be as young and fresh as possible across generations. Using adult cell, even a stem cell to make an egg probably gives it mitochondrial damage that usually takes hundreds of human generations to accumulate.
Re: The first early human eggs from stem cells
#6How hard you have to work to break scroll on web page? Nice article, but going through it was a technical nightmare. Can we stop adding unnecessary JS to website to stop global warming by calculating AND ALTERING SCROLL?
Good idea in theory but terribly impractical in practice.
Re: The first early human eggs from stem cells
#7That can't be good. Life cycle of a human egg is organized around preserving mitochondria to be as young and fresh as possible across generations. Using adult cell, even a stem cell to make an egg probably gives it mitochondrial damage that usually takes hundreds of human generations to accumulate.
I wonder if you could coax cells from the testes back into stem cells to then re-specialize into ovarian cells.
Re: The first early human eggs from stem cells
#8That can't be good. Life cycle of a human egg is organized around preserving mitochondria to be as young and fresh as possible across generations. Using adult cell, even a stem cell to make an egg probably gives it mitochondrial damage that usually takes hundreds of human generations to accumulate.
genuinely curious: how does any life still exist if this holds true?
Re: The first early human eggs from stem cells
#9How hard you have to work to break scroll on web page? Nice article, but going through it was a technical nightmare. Can we stop adding unnecessary JS to website to stop global warming by calculating AND ALTERING SCROLL?
Odd. It was a designers dream (and a readability nightmare) but I didn't have an issue with scroll.
Firefox on Samsung S23, not exactly a new or a powerful phone but rendered it fine.
Re: The first early human eggs from stem cells
#10That can't be good. Life cycle of a human egg is organized around preserving mitochondria to be as young and fresh as possible across generations. Using adult cell, even a stem cell to make an egg probably gives it mitochondrial damage that usually takes hundreds of human generations to accumulate.
Really interesting point if true. Makes sense to me, and I’m sure the team is trying to solve it