The biggest hurdles for me were - should I use separate profiles and how to get apps. Initially, I started with a separate profile for google stuff (like play store/services and apps downloaded from there, like Viber), but eventually I moved everything to the owner profile (and took a bit of a privacy and battery hit in the matter of convenience). Still, being able to control many app permissions, gives me a good state of mind that apps are not doing more then I expect.
Just looked at what android 17 brings to the table and I'm mildly excited - especially improving performance and adding more permissions (like ACCESS_LOCAL_NETWORK)