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Improvement in advanced Alzheimer’s disease following high-dose psilocybin

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Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#121

Post by threeio »

magicalhippo wrote: post #115
saltcured wrote: post #101

Earlier quoted context omitted.

If you have cared for someone with dementia, this isn't so surprising. It isn't a monotonic decline with memories disappearing forever. It is like wave upon wave of changing capacity at different time scales. The general trend is deterioration, but there are frequent periods that can almost seem like remission. There is a well known daily cycle referred to as "sundowning", where the sufferer tends to come unraveled l…

> It isn't a monotonic decline with memories disappearing forever. Last time I visited my grandpa he was really far gone. The day we arrived and subsequent two days he didn't even recognize his daughter, my mom, or even recall he had one. He'd sit in the bedroom and watch the garden, and ask "who's that guy" every 15 minutes or so, as he'd forget about me in the livingroom. The last day we visited before flying home.…

Raised with my grandmother with Alzheimer for all of my childhood she called me by her long dead brother's name.

Walked out the door one day said "See you later grandma" and she said "Have fun ______" and called me by my real name, called my older siblings and said go spend time, she died two days later.

Very common.

Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#122

Post by Marciplan »

40four wrote: post #9

This exact case study came up on a recent Rogan episode with Dean Radin, PhD. While the result is very interesting and perhaps illuminating about the unexpected biological mechanisms, apparently the effects were very short lived. Even more interesting, Dr. Radin discussed one of his companies is working on a new drug that uses the same brain receptors as psilocybin, that has the potential to induce similar effects (w…

please go find better resources over Rogan come on

Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#123

Post by agumonkey »

pixelready wrote: post #103
agumonkey wrote: post #98

Earlier quoted context omitted.

Same thing happens for other disease. Some kind of last honey moon period where your health improves and often followed by a catastrophic relapse. I'm nobody but it makes me feels there's an economic system issue, the body gradually degrades but has the ability one last time to inject a final wave of change to try restore a proper state but the resources are too short and so the attempt cannot sustain itself. I wonde…

I’ve heard this is because a lot of symptoms are not from the disease itself but actually side effects of mounting an aggressive immune system response to the underlying condition. Once your body gives up the fight as a lost cause, you will get a burst of relief and restored function from the lack of immune activity but it happens just before total system collapse.

Oh right, that seems so logical..

Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#124

Post by kube-system »

dwroberts wrote: post #20
UnfitFootprint wrote: post #3

Good riddance - this kind of thing needs to be experimented with more. But 5 grams! This reads like witch doctor science; I’m surprised it passed ethics

Yeah this story was on HN before a few weeks ago and I raised similar - it’s nuts to give that to someone who probably doesn’t have the mental state to be able to comprehend what is going on. Don’t understand how it is possibly ethical to do. Especially with the effects being temporary - can you imagine how awful it must be to regain lucidity outside of your control and then lose it again for the sake of an experimen…

> can you imagine how awful it must be to regain lucidity outside of your control and then lose it again for the sake of an experiment like this?

I would imagine the losing it again part is typically somewhat similar to how someone remembers a surgery under anesthesia -- they don't.

Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#125

Post by make3 »

elzbardico wrote: post #104
make3 wrote: post #96

Earlier quoted context omitted.

hallucinogens where taken by hippies, it was probably a way to put a few extra commies and lefties in prison

Yes, I think half of the politicians nowadays run on cocaine, no busts on TV.

why take cocaine when you can get your doctor to prescribe Adderall to you

Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#127

Post by tasty_freeze »

WhyNotHugo wrote: post #111
UnfitFootprint wrote: post #3

Good riddance - this kind of thing needs to be experimented with more. But 5 grams! This reads like witch doctor science; I’m surprised it passed ethics

5 grams isn't a high dose though, I'm not sure why it's described as such. Shops sell doses starting at 15g, although they recommend newbies take only half of that. Example of a shop which describes 5g as a "light dose": https://www.sirius.nl/atlantis/

You must be talking wet weight. 5g of dry mushrooms is about 50mg of psilocybin, which has been referred to as a "heroic dose" for decades.

Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#128

Post by elzbardico »

make3 wrote: post #125
elzbardico wrote: post #104

Earlier quoted context omitted.

Yes, I think half of the politicians nowadays run on cocaine, no busts on TV.

why take cocaine when you can get your doctor to prescribe Adderall to you

The elites get the finest Colombian artisan cocaine. Comparing it to aderall is like comparing 25 years Japanese malt to cheap Johnny Walker black.

Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#129

Post by jjgreen »

kazinator wrote: post #113
bilsbie wrote: post #49

Earlier quoted context omitted.

What’s exciting though is that this administration recently signed an executive order directing the agency to speed up the development and approval process for psychedelics.

Because Trump is in bad need of this shit?

"oh wow, look at my tiny hands, so tiny, hands"

Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#130

Post by tasty_freeze »

How is this ethical? The ethics section of the summary simply asserts it was OK, but I don't see how this being done in a private practice excuses them from normal strictures. They say this wasn't an experimental protocol, nor research, so I guess they dosed grandma for shits and giggles?

Ethics statement

Ethical approval was not required for this single case report conducted in routine private clinical practice, in accordance with local legislation and institutional requirements. No experimental protocol or prospective research procedures were conducted. Written informed consent was obtained from the patient’s legal guardian for the publication of this case report.

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