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New pancreatic cancer drug might open the door to much longer survival times

economist.com

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Re: New pancreatic cancer drug might open the door to much longer survival times

#111

Post by throwaway81523 »

epistasis wrote: post #10
basisword wrote: post #7

Earlier quoted context omitted.

What does this mean in layman's terms? How will this potentially help me if I get cancer?

Cancer is not one thing, it's a huge zoo of many many many ways that cells start to break the social contract and divide in an uncontrolled manner. One of the most commonly observed broken mechanisms is mutation in the gene KRAS that turns this on/off growth switch into the permanently on position. This has been known for decades, of course. And there have been huge amounts of effort to try to develop drugs that targ…

Can we end up with a situation like antimicrobial resistance, where cancer itself evolves to resist these new treatments?

Re: New pancreatic cancer drug might open the door to much longer survival times

#113

Post by Nifty3929 »

onesandofgrain wrote: post #57

We should be spending the same amount of money on health and disease as we spend on AI. Ogogogogogo

It is more than plausible that spending money on AI is spending money on healthcare. I believe with little certainty that AI will help us find new ways to fight disease, improve our health and live longer lives.

Re: New pancreatic cancer drug might open the door to much longer survival times

#114

Post by noisy_boy »

fhdkweig wrote: post #5

The relevant line is: "oncologists went wild over the results of a drug called daraxonrasib." https://en.wikipedia.org/wiki/Daraxonrasib

I kinda want to see a group of oncologists lose it and go wild and party like never before.

Re: New pancreatic cancer drug might open the door to much longer survival times

#115

Post by ulbu »

throwaway81523 wrote: post #111
epistasis wrote: post #10

Earlier quoted context omitted.

Cancer is not one thing, it's a huge zoo of many many many ways that cells start to break the social contract and divide in an uncontrolled manner. One of the most commonly observed broken mechanisms is mutation in the gene KRAS that turns this on/off growth switch into the permanently on position. This has been known for decades, of course. And there have been huge amounts of effort to try to develop drugs that targ…

Can we end up with a situation like antimicrobial resistance, where cancer itself evolves to resist these new treatments?

evolution is a wrong concept to approach it. cancer is not a separate life form, but a bug in the regeneration system of a complicated life form. it doesn’t exist outside of it, it cannot propagate.

Re: New pancreatic cancer drug might open the door to much longer survival times

#117

Post by 8note »

ulbu wrote: post #115
throwaway81523 wrote: post #111

Earlier quoted context omitted.

Can we end up with a situation like antimicrobial resistance, where cancer itself evolves to resist these new treatments?

evolution is a wrong concept to approach it. cancer is not a separate life form, but a bug in the regeneration system of a complicated life form. it doesn’t exist outside of it, it cannot propagate.

the single celled dog might beg to differ.

sometimes a cancer can then survive on its own back as a single celled organism

Re: New pancreatic cancer drug might open the door to much longer survival times

#118

Post by mgerdts »

pancreaticdiet wrote: post #59
rylando wrote: post #54

Earlier quoted context omitted.

Do they maintain the same diet today?

Yes. They slacked a bit some months following the surgery, and their blood markers started to drastically slip almost immediately. Might be also worth noting that prior to all of this they were a staunch "antivegan midwestern farm boy" for 70 years. Now, after witnessing the results, they are all in on the new dietary lifestyle change, and tell all their friends.

By any chance does this person live near Montrose CO and tend to the lawn at a church next to the Holiday Inn Express?

Re: New pancreatic cancer drug might open the door to much longer survival times

#119

Post by oh_my_goodness »

michaelmrose wrote: post #105
shevy-java wrote: post #86

Earlier quoted context omitted.

But that's not a cure. If they don't take that drug, assuming it works, they still have the original mutation in the cancer cells. > Patients that take part in clinical trials really are the heroes here. Are they? To me personally, putting people into a permanent state of requiring drugs to survive, is not really cure. It's just maximizing income for those selling those drugs. And none of those drugs work exceedingly…

Everyone dies. Dying 5 years later is a victory. I would go so far as saying if it was you or someone who you care about you would understand. https://usafacts.org/articles/how-have-cancer-rates-changed-... >However, even though the overall number of cases rises as the population grows, fewer people are getting and dying from cancer. Between 2000 and 2021, the incidence rate — or the rate of new cancer cases per 100,…

Unfortunately in this particular case people die about 6 months later, not 5 years. See the article.

Re: New pancreatic cancer drug might open the door to much longer survival times

#120

Post by Spooky23 »

shevy-java wrote: post #86
epistasis wrote: post #19

Earlier quoted context omitted.

The next 1-5 years will tell us which cancers this new drug will work well on, right now it's only been tried in pancreatic cancer when people have failed their first treatment. The new drug from the article, daroxonrasib, has nine trials i see currently, here: https://clinicaltrials.gov/search?intr=daraxonrasib&viewType... The first two are the trial that just completed and showed success: people that have pancreati…

But that's not a cure. If they don't take that drug, assuming it works, they still have the original mutation in the cancer cells. > Patients that take part in clinical trials really are the heroes here. Are they? To me personally, putting people into a permanent state of requiring drugs to survive, is not really cure. It's just maximizing income for those selling those drugs. And none of those drugs work exceedingly…

My wife died of aggressive melanoma. Immunotherapy would likely have helped her if not for some complications that delayed it.

Today, only 4 years later, there are two therapies, one RNA based and one CART that would have been usable in her situation. She’d be alive today most likely.

Frankly, you have no idea what you’re talking about as you spew toxic bullshit. 5 year survival would meant being there for her son through high school. That survival rate was 65% in 2022 and closer to 80% now in recent trials.

Normally I’d scroll on, but in these degenerate days it is important to counter bullshit before it becomes policy.

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