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New pancreatic cancer drug might open the door to much longer survival times

economist.com

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Re: New pancreatic cancer drug might open the door to much longer survival times

#52

Earlier quoted context omitted.

What does this mean in layman's terms? How will this potentially help me if I get cancer?

Cancer is not one thing, it's a huge zoo of many many many ways that cells start to break the social contract and divide in an uncontrolled manner. One of the most commonly observed broken mechanisms is mutation in the gene KRAS that turns this on/off growth switch into the permanently on position. This has been known for decades, of course. And there have been huge amounts of effort to try to develop drugs that targ…

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Re: New pancreatic cancer drug might open the door to much longer survival times

#53
post #52

Earlier quoted context omitted.

Cancer is not one thing, it's a huge zoo of many many many ways that cells start to break the social contract and divide in an uncontrolled manner. One of the most commonly observed broken mechanisms is mutation in the gene KRAS that turns this on/off growth switch into the permanently on position. This has been known for decades, of course. And there have been huge amounts of effort to try to develop drugs that targ…

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Are you going to give them cancer first too?

This is a horrifying proposal not only on the ethics front but also in the scientific uselessness of it.

This is exactly the type of thing that gave the Nazis the bad name they deserve.

Re: New pancreatic cancer drug might open the door to much longer survival times

#55
post #52

Earlier quoted context omitted.

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Are you going to give them cancer first too? This is a horrifying proposal not only on the ethics front but also in the scientific uselessness of it. This is exactly the type of thing that gave the Nazis the bad name they deserve.

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Re: New pancreatic cancer drug might open the door to much longer survival times

#56
post #55

Earlier quoted context omitted.

Are you going to give them cancer first too? This is a horrifying proposal not only on the ethics front but also in the scientific uselessness of it. This is exactly the type of thing that gave the Nazis the bad name they deserve.

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Until you get to the second order effects. If we want to find a cure for some disease, but we don't have enough people to do experiments on (maybe a lot of eligable prisoners died in previous trials) judges now have an incentive to hand out life sentences to people with that medical condition

Even just subconsciously that would have an effect

Re: New pancreatic cancer drug might open the door to much longer survival times

#58

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I dug a lot into "starving cancer" while we tried to save our dog from an aggressive sarcoma. I can't find his name off hand but I recall reading about a researcher who used a ketogenic diet to keep glucose low, and then occasionally gave drugs to "hammer" the cancer by quickly and temporarily depleting glutamine as well.

Re: New pancreatic cancer drug might open the door to much longer survival times

#59
post #54

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Do they maintain the same diet today?

Yes.

They slacked a bit some months following the surgery, and their blood markers started to drastically slip almost immediately.

Might be also worth noting that prior to all of this they were a staunch "antivegan midwestern farm boy" for 70 years.

Now, after witnessing the results, they are all in on the new dietary lifestyle change, and tell all their friends.

Re: New pancreatic cancer drug might open the door to much longer survival times

#60
post #55

Earlier quoted context omitted.

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Until you get to the second order effects. If we want to find a cure for some disease, but we don't have enough people to do experiments on (maybe a lot of eligable prisoners died in previous trials) judges now have an incentive to hand out life sentences to people with that medical condition Even just subconsciously that would have an effect

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