Live data from Hacker News

New pancreatic cancer drug might open the door to much longer survival times

economist.com

91–100 of 182 posts

Re: New pancreatic cancer drug might open the door to much longer survival times

#91

Please remember that science is under attack in the United States - new proposals would gut the nih even beyond the horror that is ongoing. As a scientist I am horrified and I truly hope that we don’t abandon the usas historically strong investment in the future.

I've been wondering why they attack science outside of they think it is woke and liberal. It makes no sense to cut off the hand that saves you even as a rich billionaire who wants to control people in a fascist society.

They are all about science and research. What they don’t want is for scientific discoveries to be publicly available, because then it is harder to leverage them for absurd profit margins.

Re: New pancreatic cancer drug might open the door to much longer survival times

#92
post #62

Earlier quoted context omitted.

1. Trump has been trying to cut Science budgers by larger percentages for a while now. Congress has not let them. 2. NIH funding notice of awards has slowed to a crawl since Trump did not get his wish to cut Science funding. 3. Putting scientific funding under political control, instructing them to ignore the reviews conducted by peer scientists. 4. Have practically made international collaborations on grants impossi…

[flagged]

You know so little about this, ad it is terribly frustrating to me. Scientists have been made out to be villains, when, on the whole, these are some the hardest working, most motivated people you will ever encounter.

Re: New pancreatic cancer drug might open the door to much longer survival times

#93
post #62

Earlier quoted context omitted.

[flagged]

>100% support (10s of millions of Americans do) many of these cuts when scientists are hired because they know someone, or are part of some “group” rather than being the best choice. Prove it. Prove this happens at a large scale. This is just nonsense talking points.

[flagged]

Re: New pancreatic cancer drug might open the door to much longer survival times

#94
post #32

Earlier quoted context omitted.

The golden panacea for this would be a gene editing mechanism that will work in every cell in the body. Once we have something we can do whole hog gene replacement, most human health problems would be solved forever.

For every cell mechanism that's being abused by cancer to fuel its growth, there are other cells in the body for which that mechanism is crucial for their correct functioning. Wholesale editing every cell in the body mostly guarantees that the patient does not die of cancer -- the cure will kill them before the disease does.

Only cells that have the necessary signature get the edit

Re: New pancreatic cancer drug might open the door to much longer survival times

#95

Earlier quoted context omitted.

Unfortunately, anecdotes are not data, and although a patient can try anything they want, there is no way to know that such dietary changes are beneficial or potentially harmful for most patients without doing a randomized controlled trial and hoping for strong adherence from the participants.

> anecdotes are not data It's 2026, this is SOP. It's why I referenced the metabolic pathways derived from data backed research, linked to a data driven study, and used language like "we had significant success with our loved one " and "if you want something that you can do to try ". Honestly this reads like an "aHCkTualLy!1!" from someone without experience of having a loved one suffering from a cancer diagnosis. Pe…

I have had a family member die of pancreatic cancer before age 60. It is, of course, terrible beyond belief. I'm not sure what you mean by "SOP" in this context. Referencing a bio-plausible mechanism is not actually clinically meaningful. It can provide a direction for study, but does not replace an actual clinical trial. As I said, "a patient can try anything they want".

But since we don't actually know whether such a recommendation will harm or help any individual patient, no one should be taking this recommendation as advice, and at the very least you should not be "highly recommending" specific dietary changes to people based on one anecdotal experience.

Re: New pancreatic cancer drug might open the door to much longer survival times

#96
post #93

Earlier quoted context omitted.

>100% support (10s of millions of Americans do) many of these cuts when scientists are hired because they know someone, or are part of some “group” rather than being the best choice. Prove it. Prove this happens at a large scale. This is just nonsense talking points.

[flagged]

Sigh.

I'm sure the average person was completely fed up with the federal grant process for medical issues and it was a driving force in their voting decision. Excellent proof.

Re: New pancreatic cancer drug might open the door to much longer survival times

#97

Earlier quoted context omitted.

What does this mean in layman's terms? How will this potentially help me if I get cancer?

Cancer is not one thing, it's a huge zoo of many many many ways that cells start to break the social contract and divide in an uncontrolled manner. One of the most commonly observed broken mechanisms is mutation in the gene KRAS that turns this on/off growth switch into the permanently on position. This has been known for decades, of course. And there have been huge amounts of effort to try to develop drugs that targ…

Thanks for the explanation!

Re: New pancreatic cancer drug might open the door to much longer survival times

#98

Earlier quoted context omitted.

Kindly share more details

1. Trump has been trying to cut Science budgers by larger percentages for a while now. Congress has not let them. 2. NIH funding notice of awards has slowed to a crawl since Trump did not get his wish to cut Science funding. 3. Putting scientific funding under political control, instructing them to ignore the reviews conducted by peer scientists. 4. Have practically made international collaborations on grants impossi…

Could you explain how much the US spends on its science budget compared to peers? It would help us really understand how much he's cutting it and harming our science base if we knew the numbers. For example if we're spending 50% less than EU or Canada.

Re: New pancreatic cancer drug might open the door to much longer survival times

#99

Earlier quoted context omitted.

> anecdotes are not data It's 2026, this is SOP. It's why I referenced the metabolic pathways derived from data backed research, linked to a data driven study, and used language like "we had significant success with our loved one " and "if you want something that you can do to try ". Honestly this reads like an "aHCkTualLy!1!" from someone without experience of having a loved one suffering from a cancer diagnosis. Pe…

I appreciated your comment, and strongly believe that diet and lifestyle changes are badly ignored when it comes to treating all kinds of diseases, in large part because of the difficulty of getting people to follow through. To be fair, if you're a dementia or cancer patient, making intense lifestyle changes is much harder than pills or surgery. Anyway, my point is, don't worry too much about the ignorant " but actua…

> making intense lifestyle changes is much harder than pills or surgery.

This is very true. It was certainly a lot of work for us, and a lot of work for them.

In the first months I was cooking everything.

By the end of the chemo treatment the patient had learned to cook these new meals for themselves.

Re: New pancreatic cancer drug might open the door to much longer survival times

#100

Earlier quoted context omitted.

> anecdotes are not data It's 2026, this is SOP. It's why I referenced the metabolic pathways derived from data backed research, linked to a data driven study, and used language like "we had significant success with our loved one " and "if you want something that you can do to try ". Honestly this reads like an "aHCkTualLy!1!" from someone without experience of having a loved one suffering from a cancer diagnosis. Pe…

I have had a family member die of pancreatic cancer before age 60. It is, of course, terrible beyond belief. I'm not sure what you mean by "SOP" in this context. Referencing a bio-plausible mechanism is not actually clinically meaningful. It can provide a direction for study, but does not replace an actual clinical trial. As I said, "a patient can try anything they want". But since we don't actually know whether such…

We all grieve in our own way. I am sorry for your loss.
Post reply on HN