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New pancreatic cancer drug might open the door to much longer survival times

economist.com

31–40 of 182 posts

Re: New pancreatic cancer drug might open the door to much longer survival times

#31
post #20

Earlier quoted context omitted.

It seems relevant here because the question was “How will this potentially help me if I get cancer?” and the answer is “Not at all unless you get a particular form of cancer that this applies to”. > Bacteria are also all different, but still they are "one thing", and despite their diversity, antibiotics exist that can deal with many species of them at once. Except people don’t ask “what if I get bacteria” the way the…

> Except people don’t ask “what if I get bacteria” the way they ask about cancer. Yeah, but doctors also don't tell people "you have bacteria" or claim "we found a cure for bacteria". The lack of nuance on average is largely due to a lack of nuance from experts. The media treats cancer as one big thing and bacteria and viruses as separate things. Thus the average joe inherits 'treating cancer as one big thing' from t…

I agree with you about the media. Cancer is often presented as a monolithic thing by the media. I don’t agree at all about experts. Doctors and scientists who research cancers do not lack nuance.

Re: New pancreatic cancer drug might open the door to much longer survival times

#32

Earlier quoted context omitted.

Cancer is not one thing, it's a huge zoo of many many many ways that cells start to break the social contract and divide in an uncontrolled manner. One of the most commonly observed broken mechanisms is mutation in the gene KRAS that turns this on/off growth switch into the permanently on position. This has been known for decades, of course. And there have been huge amounts of effort to try to develop drugs that targ…

The golden panacea for this would be a gene editing mechanism that will work in every cell in the body. Once we have something we can do whole hog gene replacement, most human health problems would be solved forever.

For every cell mechanism that's being abused by cancer to fuel its growth, there are other cells in the body for which that mechanism is crucial for their correct functioning. Wholesale editing every cell in the body mostly guarantees that the patient does not die of cancer -- the cure will kill them before the disease does.

Re: New pancreatic cancer drug might open the door to much longer survival times

#33

Earlier quoted context omitted.

Cancer is not one thing, it's a huge zoo of many many many ways that cells start to break the social contract and divide in an uncontrolled manner. One of the most commonly observed broken mechanisms is mutation in the gene KRAS that turns this on/off growth switch into the permanently on position. This has been known for decades, of course. And there have been huge amounts of effort to try to develop drugs that targ…

> Cancer is not one thing, I know this is a popular "well actually" to do, but it is not always useful in a conversation. Yes, all cancers are different, but yes, cancer is also one thing: unchecked, harmful division of cells. Bacteria are also all different, but still they are "one thing", and despite their diversity, antibiotics exist that can deal with many species of them at once. It is reasonable to talk about b…

Benign cancers are a thing. They might not kill like they show in the Hollywood movies, but your quality of life will be significantly diminished.

Re: New pancreatic cancer drug might open the door to much longer survival times

#34

Earlier quoted context omitted.

> Except people don’t ask “what if I get bacteria” the way they ask about cancer. Yeah, but doctors also don't tell people "you have bacteria" or claim "we found a cure for bacteria". The lack of nuance on average is largely due to a lack of nuance from experts. The media treats cancer as one big thing and bacteria and viruses as separate things. Thus the average joe inherits 'treating cancer as one big thing' from t…

Is it? I'm pretty sure oncologists will say "you have stage 2 breast cancer," but I wasn't in the room at the time.

Oncologists are actually way more specific than even that. Because there are many forms of breast cancer and different treatments depending on the type.

But yeah, oncologists aren’t telling people “you have cancer” the way they might say “you have MRSA”.

Re: New pancreatic cancer drug might open the door to much longer survival times

#36
Another ongoing HN thread from yesterday around some exciting cancer treatment breakthroughs, this time with a CRISPR Cas12a2 mechanism: https://news.ycombinator.com/item?id=48505231

This subthread there is a fascinating explainer about one user's journey into funding and incentivizing research into their own rare form of blood cancer, and how they are able to push forward the state of the art: https://news.ycombinator.com/item?id=48506997 - something of a modern-day (and more accurate) Lorenzo's Oil!

Re: New pancreatic cancer drug might open the door to much longer survival times

#37

Please remember that science is under attack in the United States - new proposals would gut the nih even beyond the horror that is ongoing. As a scientist I am horrified and I truly hope that we don’t abandon the usas historically strong investment in the future.

Kindly share more details

Re: New pancreatic cancer drug might open the door to much longer survival times

#38
post #34

Earlier quoted context omitted.

Is it? I'm pretty sure oncologists will say "you have stage 2 breast cancer," but I wasn't in the room at the time.

Oncologists are actually way more specific than even that. Because there are many forms of breast cancer and different treatments depending on the type. But yeah, oncologists aren’t telling people “you have cancer” the way they might say “you have MRSA”.

Yeah, it's WAY more specific. We got a genetic breakdown, multiple pamphlets on the drugs being used, what they are targeting, and why they work (along with the risks).

Honestly, I think people probably get false impressions because cancer usually hits old people and old people are, frankly, often not reliable narrators.

Re: New pancreatic cancer drug might open the door to much longer survival times

#39

Earlier quoted context omitted.

> Cancer is not one thing, I know this is a popular "well actually" to do, but it is not always useful in a conversation. Yes, all cancers are different, but yes, cancer is also one thing: unchecked, harmful division of cells. Bacteria are also all different, but still they are "one thing", and despite their diversity, antibiotics exist that can deal with many species of them at once. It is reasonable to talk about b…

I understand where you are coming from here, but I think it is helpful for people to overtly grasp that there are very different cancers, very different treatments, and indeed very different outcomes. Without this understanding it becomes a quick jump from "we're spending all this money on cancer" to "we've made no progress" An example of the nuance plays out in the common cancers (like breast and prostrate). These h…

The other part that is simply missing is that cancer, very unfortunately, evolves and mutates. That's how you go from a cancer that responds to treatment to one that is treatment resistant.

Like you said, for a lot of common cancers we have multiple treatments. It's usually not just one magic drug, but rather the doctors working with the most effective treatments down to the least effective treatments.

Re: New pancreatic cancer drug might open the door to much longer survival times

#40

Please remember that science is under attack in the United States - new proposals would gut the nih even beyond the horror that is ongoing. As a scientist I am horrified and I truly hope that we don’t abandon the usas historically strong investment in the future.

Kindly share more details

1. Trump has been trying to cut Science budgers by larger percentages for a while now. Congress has not let them.

2. NIH funding notice of awards has slowed to a crawl since Trump did not get his wish to cut Science funding.

3. Putting scientific funding under political control, instructing them to ignore the reviews conducted by peer scientists.

4. Have practically made international collaborations on grants impossible. An expert in Canada or Europe that would be great? Pretty much, too bad.

5. Pushing policies that make grants cancelable at any moment without need to have a justified reason, including potentially for exercising free speech, disagreeing with Administration doctrine, etc, or because you're ugly. This and the funding uncertainty makes planning difficult...just like business, stability/predictability matters.

6. Pushing policies that prevent funds to help cover costs of dissemination, including conference costs.

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