111–120 of 138 posts
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This is why you should never consent to DNA collection because they will just keep it and sell it later without paying you a cent.
You know what? Good. If there is something good in it they can have it. Probably not a whole lot in my case, but still, if this enables people to have better lives, let them go at it!
The post is written almost as if there is no prior art on (germline) variant interpretation. In fact, it is an established niche field with multiple commercial vendors existing for years (and diagnostics for critically ill infants is the most well known use case - google Stephen Kingsmore or Rady's children hospital for one). I'd be surprised if the approach is really something novel at this point. It is definitely t…
There can be plenty of prior art; however, AI can democratize that knowledge. There are many things it's helped me accomplish which are trivial to people who are far more knowledgeable than me.
nostos/limbus, genoox, engenome, congenica are a few companies/products that I have heard about and have been around for years (the last one was defunct from what I heard last however).
Disclaimer: not affiliated to any of these.
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> I’m skeptical that general purpose LLMs are a good fit for a very specialized medical analysis task If they can save more lives without harming other lives I would gladly take it during the analysis. Even saving 1% more lives is an amazing achievement!
How will this lead to saving lives? The only possible consequence is abortion?
It sounds like you just take issue with abortion. That’s more of a you problem than a problem with quantifying baby deaths.
My first son will be born in 2 months and I must say, between stories like this and others that I learned in antenatal classes - I have never been more terrified in my life
Dad of 2 girls. 8 and 4. Not saying that life couldn’t have been equally great without them, but they are amazing. Rewired me in best way possible: to appreciate non-work life as much as anything else (perhaps more). None of us really know what to do!
I was a “such is life” type of person when experiencing tragedy, and fairly ho-hum during joyous moments. With kids, something changed, or “rewired”. I tear up at Bluey episodes and lose sleep due to irrational fears of an early death and not witnessing moments in my kids’ lives.
Having and raising kids is a trip.
https://www.janestreet.com/tech-talks/algorithm-for-precisio...
It’s a fascinating story similar to this one, but using “old” AI. The dude spent years learning genetics, and built a program called “medikanren” with Will Byrd. It’s p much a huge graph database of facts they extracted from academic papers, and query using logic programming. It’s a great story
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You know what? Good. If there is something good in it they can have it. Probably not a whole lot in my case, but still, if this enables people to have better lives, let them go at it!
It's not good. They can sell it to insurance companies as well. Who might decide not to provide you with health insurance based on your genetic profile.
Aside from the sad life events, little information is shares about his "system", the thing HN is interested in. Is this more than a harness built on top of a SOTA commercial LLM?
This was not intended to be a technical post (obvious I hope). I'm planning on getting one out in the next few weeks characterizing the system and how it performed on real clinical use-cases vs. alternatives and existing tools. The TL;DR is that Gamow Labs is a harness and interface company on top of SOTA LLMs as you suggested, but my harness and interface outperforms the existing thing. While this approach would hav…
Not sure if OP is actually in here, but anybody interested in this topic should absolutely watch this talk by Matt Might: https://www.janestreet.com/tech-talks/algorithm-for-precisio... It’s a fascinating story similar to this one, but using “old” AI. The dude spent years learning genetics, and built a program called “medikanren” with Will Byrd. It’s p much a huge graph database of facts they extracted from academic…
Earlier quoted context omitted.
This was not intended to be a technical post (obvious I hope). I'm planning on getting one out in the next few weeks characterizing the system and how it performed on real clinical use-cases vs. alternatives and existing tools. The TL;DR is that Gamow Labs is a harness and interface company on top of SOTA LLMs as you suggested, but my harness and interface outperforms the existing thing. While this approach would hav…
Can you say a little more about how current genomic techniques rely on human interpretation? Is that mostly where you use an LLM (to act human-like), or is your approach different than that?
Your assumption is correct about my technique. I cloned (and expanded) this workflow into an LLM harness, so the LLM is basically orchestrating a bunch of tools that normally humans would use (and writing the conclusions and doing all the standard LLM stuff).