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Vibe coding my way to a healthy family: Introducing Gamow Labs

ddmckinnon.com

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Re: Vibe coding my way to a healthy family: Introducing Gamow Labs

#31

Post by jlengrand »

data_maan wrote: post #18

Aside from the sad life events, little information is shares about his "system", the thing HN is interested in. Is this more than a harness built on top of a SOTA commercial LLM?

"the thing HN is interested in". Really though?

We're talking about a deep human experience here. I don't know about HN as a whole but I personally come out of this much more touched about the human side of the story and how someone's life events can tremendously change their paths and goals than the LLM itself.

Re: Vibe coding my way to a healthy family: Introducing Gamow Labs

#32

Post by arjie »

fabbbbb wrote: post #16

It reads like a specific genome would lead to deterministic outcomes. It does not. Life is messy. Most Down Syndrome people have happy lives, some can even live alone and have an independent daily live. Life expectancy is up to 60 years. Yet in Iceland „Democratization“ of genetic diagnosis lead to basically 0% Down Syndrome kids (births). Where does this stop? What with someone of a genetic indication of aggressive…

With pre-implantation genetic testing, a sufficiently large number of embryos, and a sufficiently small number of children desired, it's just a ranking question. A pair of parents with 6 embryos, and 2-3 children desired will likely just try their most viable embryos first. One can argue that they should try the embryos that carry known conditions before they try the ones that don't, but I can't imagine under what ethical structure that is desirable.

As for trisomy-21, if we wish to increase the rates in the future we can stop performing pre-implantation testing and the MSAFP and nuchal translucency and so on. After all, even if we abort all embryos that carry the markers today, new such embryos will be formed in the future since it comes from non-disjunction so selection pressure once removed will allow it to return.

Re: Vibe coding my way to a healthy family: Introducing Gamow Labs

#33

Post by inglor_cz »

fabbbbb wrote: post #16

It reads like a specific genome would lead to deterministic outcomes. It does not. Life is messy. Most Down Syndrome people have happy lives, some can even live alone and have an independent daily live. Life expectancy is up to 60 years. Yet in Iceland „Democratization“ of genetic diagnosis lead to basically 0% Down Syndrome kids (births). Where does this stop? What with someone of a genetic indication of aggressive…

Most cannot live alone and their parents have to take care about a huge, powerful 100 kg baby that needs constant attention until its death.

My friend from elementary school has had a Down kid at 19. She takes it well, but managing a grown-up man five times as strong as her (she is petite) when he decides to do something like "take his bicycle and ride on a busy highway" is exhausting.

This is why most people abort Down fetuses.

Re: Vibe coding my way to a healthy family: Introducing Gamow Labs

#35

Post by fabbbbb »

inglor_cz wrote: post #33
fabbbbb wrote: post #16

It reads like a specific genome would lead to deterministic outcomes. It does not. Life is messy. Most Down Syndrome people have happy lives, some can even live alone and have an independent daily live. Life expectancy is up to 60 years. Yet in Iceland „Democratization“ of genetic diagnosis lead to basically 0% Down Syndrome kids (births). Where does this stop? What with someone of a genetic indication of aggressive…

Most cannot live alone and their parents have to take care about a huge, powerful 100 kg baby that needs constant attention until its death. My friend from elementary school has had a Down kid at 19. She takes it well, but managing a grown-up man five times as strong as her (she is petite) when he decides to do something like "take his bicycle and ride on a busy highway" is exhausting. This is why most people abort D…

Does this make sense to you and her? Does she wish the kid would not have been born?

Re: Vibe coding my way to a healthy family: Introducing Gamow Labs

#36

Post by nkrisc »

fabbbbb wrote: post #16

It reads like a specific genome would lead to deterministic outcomes. It does not. Life is messy. Most Down Syndrome people have happy lives, some can even live alone and have an independent daily live. Life expectancy is up to 60 years. Yet in Iceland „Democratization“ of genetic diagnosis lead to basically 0% Down Syndrome kids (births). Where does this stop? What with someone of a genetic indication of aggressive…

People born with Down syndrome deserve all the respect and dignity any other person does.

I have two kids. If I could have chosen whether or not they would be born with Down syndrome I would choose would “without” every single time. If either of them were born with it I would love them the same but I would never choose it, if I had the choice to make.

Re: Vibe coding my way to a healthy family: Introducing Gamow Labs

#37

Post by fabbbbb »

throwaw12 wrote: post #26
ungreased0675 wrote: post #2

I’m skeptical that general purpose LLMs are a good fit for a very specialized medical analysis task. Something trained specifically for the task would be the path I’d explore.

> I’m skeptical that general purpose LLMs are a good fit for a very specialized medical analysis task If they can save more lives without harming other lives I would gladly take it during the analysis. Even saving 1% more lives is an amazing achievement!

How will this lead to saving lives? The only possible consequence is abortion?

Re: Vibe coding my way to a healthy family: Introducing Gamow Labs

#38

Post by akie »

fabbbbb wrote: post #35
inglor_cz wrote: post #33

Earlier quoted context omitted.

Most cannot live alone and their parents have to take care about a huge, powerful 100 kg baby that needs constant attention until its death. My friend from elementary school has had a Down kid at 19. She takes it well, but managing a grown-up man five times as strong as her (she is petite) when he decides to do something like "take his bicycle and ride on a busy highway" is exhausting. This is why most people abort D…

Does this make sense to you and her? Does she wish the kid would not have been born?

Such an inconsiderate and loaded question.

Screening an embryo that could not survive outside the womb and deciding to stop the pregnancy based on the results is not the same as "wishing the kid wasn't born".

Re: Vibe coding my way to a healthy family: Introducing Gamow Labs

#39

Post by fabbbbb »

vasco wrote: post #13
tedesign wrote: post #6

This is extremely disturbing.

Man tries to find way to improve situation that gave him needless distress surrounding the death of his newborn. Internet reply: this is extremely disturbing

Well the „improvement“ here seems to be „it has some likelihood of genetic disorder let’s speed up death“

Re: Vibe coding my way to a healthy family: Introducing Gamow Labs

#40

Post by pietro72ohboy »

jlengrand wrote: post #31
data_maan wrote: post #18

Aside from the sad life events, little information is shares about his "system", the thing HN is interested in. Is this more than a harness built on top of a SOTA commercial LLM?

"the thing HN is interested in". Really though? We're talking about a deep human experience here. I don't know about HN as a whole but I personally come out of this much more touched about the human side of the story and how someone's life events can tremendously change their paths and goals than the LLM itself.

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