Imagine something like this happening halfway to Mars and zero chance of escaping, getting any help or parts sent to you.
Seems like these structural integrity problems are always inside the Russian section. So if you're on a Russian mission to Mars, yes it would be reasonable to be worried. Otherwise this seems like a non-issue.
Except you forgot to mention an epic leak in Destiny just three years after it was attached to the ISS: "At its highest rate, the station was leaking about 5 pounds of air per day overboard." [0] Imagine that happening on the 4th year of American Mars mission.
Also, if you on American mission to Mars, it would be reasonable to worry about cooling system dying mid-flight requiring three spacewalks to fix it: "We'd lose cooling capability to half of the electronics on the U.S., European and Japanese part of the space station." [1]