161–170 of 395 posts
Has anyone else had GI issues from creatine? Even at low doses?
Isn't that, like, the most common side effect of it? I was just googling for side effects, and different sources vary a bit, but almost all list digestive discomfort
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19 patients completed, according to the article. And List Sorting, Oral reading, and Flanker only? The first and last are part of global and fluid composites, so those have to be excluded from comparison. That leaves us with 3 improved scores out of 12 tests. So 9 did not improve, or got worse. Figure 3 (of the original article) shows that the changes aren't big. Just "significant". Since the participants were in the…
Sounds like something we should study more rather than dismiss.
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This is a myth, its not bad for your kidneys. The reason this gets spread is because you will have higher levels of creatine in your urine if your Doctor tests your urine for kidney function, which indicates kidney disease. However, If you reveal to that doctor that you're supplementing Creatine it will not be concern them.
At the risk of sounding stupid. Doesn’t this mean it would mask actual kidney disease? So you’d be ignoring potential warning signs.
Side question: I've always been a recreational runner, running 3/4x a week, completed a few half marathons, and recently decided to _also_ go to the gym to do strength training as it has a lot of benefits for runners too. Should I consider/take creatine, is it useful?
If you intend to have any benefits of going to the gym then protein (and overall calorie consumption) would have to be monitored.
Running sort of conflicts with working out: it wants you to be light and burns plenty of energy.
Gym wants you to gain mass. No mass gains -> gym us useless.
Creatine is kind of an afterthought in this bigger picture. Might give you an extra rep or two but that's it.
besides i’d rather just avoid brainrot and substances in general
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I don't know what your experience is, according to mine there are some people who are better than chance at picking this up. And I believe my experience is something expected. People are also certain kind of a neural network. If an LLM system is trainable to be a decent detector, I don't see a reason why at least some people couldn't be.
I haven't seen any evidence an LLM is trainable to be a decent detector for anything people have made any kind of attempts at trying to get past them. Which is as expected as access to a detector effectively makes the problem equivalent to the halting problem (you can tweak the output using a detector as judge until you have a process to bypass it). Some of them are somewhat able to recognised "raw" output.
Similar as with coding, yes, halting problem!, but we've been always reviewing code nonetheless.
The article made up the claim it’s not from the paper itself. There was some improvement in cognitive scores, but no placebo group. Without a placebo group, there are a lot of explanations for the data.
I'll add to this: the referenced trial occurred over 8 weeks, so even if we stipulate that the improvements in cognition (which are dubious, as tgv points out in this comment: https://news.ycombinator.com/item?id=48347906) are due to treatment rather than some other effect, we don't know that the effect is disease-modifying as opposed to symptomatic. As with acetylcholinesterase inhibitors, it may just be having a cognition-enhancing effect which, nevertheless, does not alter the underlying disease trajectory (i.e. just shifting the declining trajectory up vertically by a constant amount), and might revert shortly after discontinuing use of the drug.
A controlled trial, over a much longer duration, and ideally with a wash-out period, would be necessary to identify a disease-modifying effect.
Curious if anyone has had hair issues while taking it. I’m aware that there’s no positive evidence for an effect, but there is an at least plausible mechanism. I’ve gone through two periods where I took it and liked the effects, but felt like I shed way more hair and stopped due to that.
Side question: I've always been a recreational runner, running 3/4x a week, completed a few half marathons, and recently decided to _also_ go to the gym to do strength training as it has a lot of benefits for runners too. Should I consider/take creatine, is it useful?
I take 10g creatine, it did wonders for me. More energy and mental sharpness.
Strength training is essential for runners to avoid injury at high mileage. Sleep, strength, and nutrition. It can’t be ignored or you will get injured.
Some folks mention cutting it out to lose weight but at higher mileage I find it hard to keep on weight anyway.