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Scientists say they've reversed brain aging in mice with a nasal spray

sciencedaily.com

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Re: Scientists say they've reversed brain aging in mice with a nasal spray

#21
edit: admin dang has fixed the title

I always interpret the rule [0] "Otherwise please use the original title, unless it is misleading or linkbait; don't editorialize." as applying to stories like this one.

Adding the words [in mice] would not only be the acceptable exception the rule is referring to, but probably necessary. This would align the title properly with the article contents and avoid giving people false expectations about human results.

[0] https://news.ycombinator.com/newsguidelines.html

Re: Scientists say they've reversed brain aging in mice with a nasal spray

#22

Earlier quoted context omitted.

Presumably this drug (like all the others) is dirt-cheap to synthesize and the only reason anything is expensive is a government granted monopoly that’s nominally encouraging innovation

I don't grant the assumption that innovation is helped with the current US system. It is entirely possible that it is actually hurt considerably compared to other systems. There is a massive incentive to prolong health problems if you make money on treating them. Even without people being evil, when the major learning signal (money) points constantly towards 'prolong the problem' it isn't hard to imagine that the sys…

I want to agree with you but have other systems provided better drugs / research than the US? Afaik SOTA in anything medical is basically US researched but .. I haven't actually looked into it that much.

Re: Scientists say they've reversed brain aging in mice with a nasal spray

#24
post #7

“While additional research is still needed before the treatment could be tested in humans, the study offers a striking possibility.” (In mice)

We are going to end up with immortal mice.

Actually the fact that we don’t have immortal mice is what makes me feel like this current optimism with respect to life extension is pretty unrealistic.

Re: Scientists say they've reversed brain aging in mice with a nasal spray

#25

edit: admin dang has fixed the title I always interpret the rule [0] "Otherwise please use the original title, unless it is misleading or linkbait; don't editorialize." as applying to stories like this one. Adding the words [in mice] would not only be the acceptable exception the rule is referring to, but probably necessary. This would align the title properly with the article contents and avoid giving people false e…

[dead]

Re: Scientists say they've reversed brain aging in mice with a nasal spray

#26
post #13

> Behavioral testing showed that treated models performed significantly better on memory and recognition tasks. "Treated models" - it sounds like they're trying really hard to hide the fact that this was all in mice. From the paper: > Therefore, using a mouse model, this study investigated whether IN administration of hiPSC-NSC-EVs in late middle age can significantly reduce oxidative stress and curb microglia-mediat…

Ok, I've inmiced the title above. Thanks for catching this.

Re: Scientists say they've reversed brain aging in mice with a nasal spray

#27

These billionaire mice are funding this research; humans should do the same

So you are telling me that the mice from Hitchhikers guide are real?

“These creatures you call mice you see are not quite as they appear, they are merely the protrusions into our dimension of vast, hyper-intelligent pan-dimensional beings.”

—Slartibartfast

Re: Scientists say they've reversed brain aging in mice with a nasal spray

#28
post #3

The source paper: https://isevjournals.onlinelibrary.wiley.com/doi/10.1002/jev...

Addition of a source-paper link to complex science studies like this should be encouraged (if not mandatory) at the top of posts like this.

Real-world reports can be valuable to some readers who are non-plussed by journalistic interpretations.I don't see deception going on in this one; it's clear about its limits.

Re: Scientists say they've reversed brain aging in mice with a nasal spray

#30
post #13

> Behavioral testing showed that treated models performed significantly better on memory and recognition tasks. "Treated models" - it sounds like they're trying really hard to hide the fact that this was all in mice. From the paper: > Therefore, using a mouse model, this study investigated whether IN administration of hiPSC-NSC-EVs in late middle age can significantly reduce oxidative stress and curb microglia-mediat…

ctrl+f'd for 'mice', no results. I can think of no other word than deceit.

It’s very probably not deceit, it’s just biomedical research jargon from the original paper that was written for a scientist audience that didn’t get translated to a lay audience language for a sciencedaily/press release format.
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