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Scientists say they've reversed brain aging in mice with a nasal spray

sciencedaily.com

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Re: Scientists say they've reversed brain aging in mice with a nasal spray

#11

Post by MattDamonSpace »

delichon wrote: post #10

I'm afraid of the result if we take someone wrapped in a comforting haze of dementia (I'm getting there) and force them into cold harsh reality. It may be as welcome a sobriety to an alcoholic. If the insurance stops paying does it become Flowers for Algernon? We have several drugs that emulate dementia in various ways and call them recreational.

Presumably this drug (like all the others) is dirt-cheap to synthesize and the only reason anything is expensive is a government granted monopoly that’s nominally encouraging innovation

Re: Scientists say they've reversed brain aging in mice with a nasal spray

#13

Post by qnleigh »

> Behavioral testing showed that treated models performed significantly better on memory and recognition tasks.

"Treated models" - it sounds like they're trying really hard to hide the fact that this was all in mice. From the paper:

> Therefore, using a mouse model, this study investigated whether IN administration of hiPSC-NSC-EVs in late middle age can significantly reduce oxidative stress and curb microglia-mediated neuroinflammaging in the hippocampus.

Cool! But please be honest in your press releases.

Re: Scientists say they've reversed brain aging in mice with a nasal spray

#14

Post by cookiengineer »

ianburrell wrote: post #12
instagib wrote: post #7

“While additional research is still needed before the treatment could be tested in humans, the study offers a striking possibility.” (In mice)

We are going to end up with immortal mice.

Always pack your towel for space travel!

Re: Scientists say they've reversed brain aging in mice with a nasal spray

#15

Post by jmward01 »

MattDamonSpace wrote: post #11
delichon wrote: post #10

I'm afraid of the result if we take someone wrapped in a comforting haze of dementia (I'm getting there) and force them into cold harsh reality. It may be as welcome a sobriety to an alcoholic. If the insurance stops paying does it become Flowers for Algernon? We have several drugs that emulate dementia in various ways and call them recreational.

Presumably this drug (like all the others) is dirt-cheap to synthesize and the only reason anything is expensive is a government granted monopoly that’s nominally encouraging innovation

I don't grant the assumption that innovation is helped with the current US system. It is entirely possible that it is actually hurt considerably compared to other systems. There is a massive incentive to prolong health problems if you make money on treating them. Even without people being evil, when the major learning signal (money) points constantly towards 'prolong the problem' it isn't hard to imagine that the system that evolves from it is actively worse than nearly any other system with a good loss function like 'health' or even just 'fame and notoriety for the scientists involved'

Re: Scientists say they've reversed brain aging in mice with a nasal spray

#16

Post by ryankrage77 »

qnleigh wrote: post #13

> Behavioral testing showed that treated models performed significantly better on memory and recognition tasks. "Treated models" - it sounds like they're trying really hard to hide the fact that this was all in mice. From the paper: > Therefore, using a mouse model, this study investigated whether IN administration of hiPSC-NSC-EVs in late middle age can significantly reduce oxidative stress and curb microglia-mediat…

ctrl+f'd for 'mice', no results. I can think of no other word than deceit.

Re: Scientists say they've reversed brain aging in mice with a nasal spray

#20

Post by skissane »

jmward01 wrote: post #15
MattDamonSpace wrote: post #11

Earlier quoted context omitted.

Presumably this drug (like all the others) is dirt-cheap to synthesize and the only reason anything is expensive is a government granted monopoly that’s nominally encouraging innovation

I don't grant the assumption that innovation is helped with the current US system. It is entirely possible that it is actually hurt considerably compared to other systems. There is a massive incentive to prolong health problems if you make money on treating them. Even without people being evil, when the major learning signal (money) points constantly towards 'prolong the problem' it isn't hard to imagine that the sys…

China is making huge investments in biotech, and its regulators tend to be more permissive than those in many Western countries. It would not surprise me if sooner or later, China begins to take the lead in medical innovation and the US is reduced to playing catch-up.

Of course, more permissive regulation means increased safety risks for consumers and clinical trial participants-but if you don’t live in China, that’s a price you won’t personally pay.

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