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Acetaminophen vs. ibuprofen

asteriskmag.com

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Re: Acetaminophen vs. ibuprofen

#191

Post by rustyhancock »

watwut wrote: post #166
iamniels wrote: post #130

Earlier quoted context omitted.

In Western Europe too. > but it does absolutely nothing with actual pain. It is placebo at best. This is simply false.

It is not false. It does nothing. Head hurts, you take paracetamol ... head still hurts. The belly hurts, you take paracetamol ... nothing change. When I took ibuprofen it did actually made an actual real change.

You're partially right compared to placebo only about 5% of people are painfree over the effect of a placebo when taking paracetamol.

Paracetamol got it's start as replacing the more effective but much more dangerous and withdrawn drug Phenacetin.

Why don't people notice that it's such a small benefit over nothing? Well because placebo effect is quite good for pain and pain is usually transitory anywhere..if you have a tension headache you're probably going to aim to relax. Turn away from the screen or even have some caffeine and those are more effective than paracetamol!

Re: Acetaminophen vs. ibuprofen

#192

Post by Dries007 »

petesergeant wrote: post #40
vasco wrote: post #35

Earlier quoted context omitted.

Or 10 slightly larger ones edit: https://www.24pharma.nl/paracetamol-eg-1000mg-120-tabletten

I’ve pretty much only ever seen them sold at 500mg; are you regularly seeing them where you are sold in 1g form?

The linked size is also quite common in Belgium.

Re: Acetaminophen vs. ibuprofen

#193

Post by d--b »

To me it's obvious that acetaminophen and ibuprofen do not target the same kind of problems. I am not a woman, but my wife says acetaminophen does not work on menstrual pain for instance.

I take acetaminophen for fever, and those kind of full-body diffuse ill-feeling.

I take ibuprofen for localized intense pain.

I take aspirin for headaches and sore muscles.

Re: Acetaminophen vs. ibuprofen

#194

Post by jcynix »

user_7832 wrote: post #63
eru wrote: post #53

Earlier quoted context omitted.

Here in Singapore NAC is sold to make muckus more liquid to alleviate coughs. Apparently for some people it also helps with lessening tolerance for their ADHD meds, but I'm not so sure about that.

> Apparently for some people it also helps with lessening tolerance for their ADHD meds, but I'm not so sure about that. I'd believe it. I first heard of NAC on the nootropic subreddit in a past lifetime. The benefits vary, but generally it's a safe thing with a low chance of making anything worse , but a possibility to improve things. Many neurodivergent folk have written about how they benefit. I'd give more info o…

You'll find a detailed description oft potential effects and uses here: https://en.wikipedia.org/wiki/Acetylcysteine (aka NAC)

Re: Acetaminophen vs. ibuprofen

#196

Post by wouldbecouldbe »

shankr wrote: post #168
wouldbecouldbe wrote: post #123

Earlier quoted context omitted.

Try dealing with a herniated disc, more ibu is definitely better. Too little wont do anything, proper dose and you feel healed

Yeah can confirm. I try to keep it low but then pain lingers for days and cumulatively over the days most probably I took as much as I should have taken in stating few days already.

yeah tried to reserve ibu for sleep and during the day walking as much as possible. I know not everyone feels better while walking, luckily I did.

Re: Acetaminophen vs. ibuprofen

#197

Post by jcynix »

dgan wrote: post #135
pugio wrote: post #17

Really lovely article. In paramedicine we usually treat 10g of acetaminophen in a 24-hour window as a potentially fatal overdose. That's also why the law in Australia was changed to require acetaminophen to come in blister packs (harder to get each pill out) of no more than 16. At 500 mg, that only gets you up to 8 g if you eat the whole thing, which is still hopefully non-fatal. I always thought a simple over-the-co…

I randomly bought NAC just to try it. I dont know about the chemical interactions, but going out with collegues at that time taught me that it's basically impossible to get drunk. Usually a pint of beer is enough to make le feel at least a little dizzy, but when taking NAC, it was all like drinking water

NAC taken before consuming alcohol has a positive effect apparently, but taken afterwards it's detrimental as mentioned here: https://en.wikipedia.org/wiki/Acetylcysteine

Re: Acetaminophen vs. ibuprofen

#198

Post by keane »

dgan wrote: post #135
pugio wrote: post #17

Really lovely article. In paramedicine we usually treat 10g of acetaminophen in a 24-hour window as a potentially fatal overdose. That's also why the law in Australia was changed to require acetaminophen to come in blister packs (harder to get each pill out) of no more than 16. At 500 mg, that only gets you up to 8 g if you eat the whole thing, which is still hopefully non-fatal. I always thought a simple over-the-co…

I randomly bought NAC just to try it. I dont know about the chemical interactions, but going out with collegues at that time taught me that it's basically impossible to get drunk. Usually a pint of beer is enough to make le feel at least a little dizzy, but when taking NAC, it was all like drinking water

Just a note: “research about the safety of taking NAC every day for the long term is limited.” cf. a concerning 2019 animal study regarding higher risks of cancer https://doi.org/10.1172/jci.insight.127647 also discussed at https://www.science.org/content/blog-post/n-acetyl-cysteine-...

Re: Acetaminophen vs. ibuprofen

#199

Post by ButlerianJihad »

jcynix wrote: post #197
dgan wrote: post #135

Earlier quoted context omitted.

I randomly bought NAC just to try it. I dont know about the chemical interactions, but going out with collegues at that time taught me that it's basically impossible to get drunk. Usually a pint of beer is enough to make le feel at least a little dizzy, but when taking NAC, it was all like drinking water

NAC taken before consuming alcohol has a positive effect apparently, but taken afterwards it's detrimental as mentioned here: https://en.wikipedia.org/wiki/Acetylcysteine

Vaccine Ordering https://xkcd.com/2422/

Re: Acetaminophen vs. ibuprofen

#200

Post by keane »

djsavvy wrote: post #62
rao-v wrote: post #36

Earlier quoted context omitted.

Could somebody package Tylenol with a sufficient amount of NAC to de-risk it? I suspect such a formulation would not require trials?

See superscript 6 on the article. Apparently NAC might has side effects of its own.

One of the side effects in a study in mice was inducing lung cancer: https://doi.org/10.1172/jci.insight.127647
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