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Acetaminophen vs. ibuprofen

asteriskmag.com

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Re: Acetaminophen vs. ibuprofen

#51

Post by Natsu »

pugio wrote: post #17

Really lovely article. In paramedicine we usually treat 10g of acetaminophen in a 24-hour window as a potentially fatal overdose. That's also why the law in Australia was changed to require acetaminophen to come in blister packs (harder to get each pill out) of no more than 16. At 500 mg, that only gets you up to 8 g if you eat the whole thing, which is still hopefully non-fatal. I always thought a simple over-the-co…

I've heard it suggested that acetaminophen just come with a small dose of NAC alongside it to make it safer. I guess this would require a lot of regulatory work to approve, but given that 500 people a year OD, it seems like a thing we should at least consider.

Meanwhile, it's funny that it seems like acetaminophen should safer in more scenarios, but the other has a lot of overdoses with typical use, I guess that's why there's a gap between the two, because ODs are apparently a lot more common or at least more legible than problems caused by the other drug.

Re: Acetaminophen vs. ibuprofen

#52

Post by devmor »

throwaway27448 wrote: post #27
pugio wrote: post #17

Really lovely article. In paramedicine we usually treat 10g of acetaminophen in a 24-hour window as a potentially fatal overdose. That's also why the law in Australia was changed to require acetaminophen to come in blister packs (harder to get each pill out) of no more than 16. At 500 mg, that only gets you up to 8 g if you eat the whole thing, which is still hopefully non-fatal. I always thought a simple over-the-co…

What does ingesting 10g of acetaminophen even look like? I've got to imagine the fatal dose is far, far, far lower with chronic usage. Finding out that people are ingesting grams is profoundly disturbing.

I have taken 4-5g in a day while suffering from intense pain before.

There is a limit to the amount of opioids they will prescribe you, even if you are in mind shattering pain. For instance while attempting to get your dental insurance to actually cover a treatment you may find yourself between risking organ damage or risking $5000+ in ER visit bills only to have them refuse to give you anything but Tramadol.

Re: Acetaminophen vs. ibuprofen

#53

Post by eru »

pugio wrote: post #17

Really lovely article. In paramedicine we usually treat 10g of acetaminophen in a 24-hour window as a potentially fatal overdose. That's also why the law in Australia was changed to require acetaminophen to come in blister packs (harder to get each pill out) of no more than 16. At 500 mg, that only gets you up to 8 g if you eat the whole thing, which is still hopefully non-fatal. I always thought a simple over-the-co…

Here in Singapore NAC is sold to make muckus more liquid to alleviate coughs.

Apparently for some people it also helps with lessening tolerance for their ADHD meds, but I'm not so sure about that.

Re: Acetaminophen vs. ibuprofen

#54

Post by throwaway27448 »

protocolture wrote: post #47
throwaway27448 wrote: post #39

Earlier quoted context omitted.

Is this not suicidal behavior?

I took 2 full packs in a day once while trying to recover from severe pain. Didnt find out until later that it was supposedly a fatal dose.

Mm. Apparently i don't understand pain and the medication it drives people towards.

Re: Acetaminophen vs. ibuprofen

#55

Post by burnt-resistor »

foobiekr wrote: post #22
farmeroy wrote: post #10

I've known people who've overdosed on Tylenol and died. I'm not saying that ibuprofen won't give you acid reflux and won't damage your kidneys, but due to I tend to take a lot of ibuprofen and also for take another medication that constricts my arteries and for get a lot of blood/urine work done... and my kidney function is good and despite everything I'm generally healthy. So I would say, like many things, what medi…

Just don't take it on an empty stomach.

That's ibuprofen. Which can be partially mitigated by famotidine.

IBU: -stomach -kidneys -bp+ -clotting --NERD --NECD --NEUD --SNIUAA --SNIDR --DRESS

APAP: -liver --DRESS

-- extreme, rare side-effects

Re: Acetaminophen vs. ibuprofen

#57

Post by simoncion »

throwaway27448 wrote: post #54
protocolture wrote: post #47

Earlier quoted context omitted.

I took 2 full packs in a day once while trying to recover from severe pain. Didnt find out until later that it was supposedly a fatal dose.

Mm. Apparently i don't understand pain and the medication it drives people towards.

> Apparently i don't understand pain...

Speaking as someone who is not-infrequently in significant pain, I sincerely hope that you never have to.

Re: Acetaminophen vs. ibuprofen

#58

Post by sph »

burnt-resistor wrote: post #55
foobiekr wrote: post #22

Earlier quoted context omitted.

Just don't take it on an empty stomach.

That's ibuprofen. Which can be partially mitigated by famotidine. IBU: -stomach -kidneys -bp+ -clotting --NERD --NECD --NEUD --SNIUAA --SNIDR --DRESS APAP: -liver --DRESS -- extreme, rare side-effects

You expect us to know those acronyms?

Re: Acetaminophen vs. ibuprofen

#59

Post by sozforex »

applfanboysbgon wrote: post #41
throwaway27448 wrote: post #39

Earlier quoted context omitted.

Is this not suicidal behavior?

This can easily happen over the course of 24 hours if you're in "fuck me I'll do anything to make it stop" levels of pain. I've taken more than 20 ibuprofens in a day a few times in my life, which, while not medically advised, did not kill me. I actually had no idea acetaminophen was so dangerous.

Just in case, ibuprophen does not work well for pain relief [at lest for some kind of pain]. Paracetamol [acetaminophen] usually is much better against pain. And paracetamol + ibuprophen can help with strong pain for which neither paracetamol or ibuprophen work at normal doses.

Re: Acetaminophen vs. ibuprofen

#60

Post by triage8004 »

pugio wrote: post #17

Really lovely article. In paramedicine we usually treat 10g of acetaminophen in a 24-hour window as a potentially fatal overdose. That's also why the law in Australia was changed to require acetaminophen to come in blister packs (harder to get each pill out) of no more than 16. At 500 mg, that only gets you up to 8 g if you eat the whole thing, which is still hopefully non-fatal. I always thought a simple over-the-co…

NAC is so amazing for us in terribly polluted areas. Also great before drinking
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