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Acetaminophen vs. ibuprofen

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Re: Acetaminophen vs. ibuprofen

#41

Earlier quoted context omitted.

> What does ingesting 10g of acetaminophen even look like? 20 not-especially-large tablets

Is this not suicidal behavior?

This can easily happen over the course of 24 hours if you're in "fuck me I'll do anything to make it stop" levels of pain. I've taken more than 20 ibuprofens in a day a few times in my life, which, while not medically advised, did not kill me. I actually had no idea acetaminophen was so dangerous.

Re: Acetaminophen vs. ibuprofen

#42

I've known people who've overdosed on Tylenol and died. I'm not saying that ibuprofen won't give you acid reflux and won't damage your kidneys, but due to I tend to take a lot of ibuprofen and also for take another medication that constricts my arteries and for get a lot of blood/urine work done... and my kidney function is good and despite everything I'm generally healthy. So I would say, like many things, what medi…

> You just might die from taking tylenol if you don't realize your liver is already damaged for other reasons.

If you don’t realize your kidneys are already damaged you might die from kidney failure because of ibuprofen.

Re: Acetaminophen vs. ibuprofen

#43

The following article showing a link between Acetaminophen/Paracetamol usage and decline in positive empathy is highly relevant here; The medications that change who we are - https://www.bbc.com/future/article/20200108-the-medications-... Excerpt: Mischkowski’s own research has uncovered a sinister side-effect of paracetamol. For a long time, scientists have known that the drug blunts physical pain by reducing activi…

> Mischkowski suspects that this would also be more difficult to summon after taking the drug.

Why should I trust someone who doesn’t test properly but just suspects?

Re: Acetaminophen vs. ibuprofen

#44

IANADATINMA. Max dose combination (IBU/APAP FDC) can be useful as a substitute in emergency therapeutic situations compared to opiates. Not recommended ordinarily because of liver, kidney, and stomach impairment.[0] Taking ibuprofen with questionable stomach condition may want to consider taking a famotidine adjuvant or duexis [1] or acetaminophen instead. Overdose treatment of acetaminophen poisoning is the stinky N…

For those who struggled similarly to me:

I Am Not A Doctor And This Is Not Medical Advice.

(I think?).

Re: Acetaminophen vs. ibuprofen

#45
post #17

Really lovely article. In paramedicine we usually treat 10g of acetaminophen in a 24-hour window as a potentially fatal overdose. That's also why the law in Australia was changed to require acetaminophen to come in blister packs (harder to get each pill out) of no more than 16. At 500 mg, that only gets you up to 8 g if you eat the whole thing, which is still hopefully non-fatal. I always thought a simple over-the-co…

You can still die if you take your idiot-proof Aussie blister packs with alcohol. So it's more an inefficient use of cabinet space. You can overdose on water too, they haven't banned 5-gallon jugs (yet).

No. Ethanol and tylenol compete for CYP2E1 that produces toxic NAPQI, so no, acute alcohol intoxication has a protective effect at least where it comes to tylenol toxicity.

Re: Acetaminophen vs. ibuprofen

#46
post #17

Really lovely article. In paramedicine we usually treat 10g of acetaminophen in a 24-hour window as a potentially fatal overdose. That's also why the law in Australia was changed to require acetaminophen to come in blister packs (harder to get each pill out) of no more than 16. At 500 mg, that only gets you up to 8 g if you eat the whole thing, which is still hopefully non-fatal. I always thought a simple over-the-co…

What does ingesting 10g of acetaminophen even look like? I've got to imagine the fatal dose is far, far, far lower with chronic usage. Finding out that people are ingesting grams is profoundly disturbing.

Taking too much acetaminophen is bad for you but 10g is 20 extra strength pills and that much isn't likely at all to kill you but damage your organs is quite possible. Reading this might make someone in a bad place think that much will do the job and it won't. Tylenol poisoning's most likely outcome is permanent organ damage and pain, don't try it.

Re: Acetaminophen vs. ibuprofen

#47

Earlier quoted context omitted.

> What does ingesting 10g of acetaminophen even look like? 20 not-especially-large tablets

Is this not suicidal behavior?

I took 2 full packs in a day once while trying to recover from severe pain. Didnt find out until later that it was supposedly a fatal dose.

Re: Acetaminophen vs. ibuprofen

#48
post #5

This is some of the most useful information I've received in a while. Like the author, the low overdose threshold of acetaminophen made me avoid it, even though I always take low doses anyway and ibuprofen gives me acid reflux almost every time.

Same here. Great article. I avoid both and stick with naproxen sodium. Any issues with that one? Lasts the longest too.

None of us are your doctors but Naproxen has well-known gastric issues up to ulcers and stomach bleeding which is why it's advised to be taken with food and why it's also often prescribed with a PPI or H2 Antagonist. Cox-2 selectives such as Celecoxib greatly reduce this risk but seem to be associated with some small cardiovascular risk (admittedly this is a feature of all NSAIDs though less so in Naproxen apparently).

Re: Acetaminophen vs. ibuprofen

#49
post #43

The following article showing a link between Acetaminophen/Paracetamol usage and decline in positive empathy is highly relevant here; The medications that change who we are - https://www.bbc.com/future/article/20200108-the-medications-... Excerpt: Mischkowski’s own research has uncovered a sinister side-effect of paracetamol. For a long time, scientists have known that the drug blunts physical pain by reducing activi…

> Mischkowski suspects that this would also be more difficult to summon after taking the drug. Why should I trust someone who doesn’t test properly but just suspects?

What? Read the article fully; it has to do with "negative empathy" different from "positive empathy".

Dominik Mischkowski is a Pain Researcher at Ohio University who has been studying this for a while. The word "suspects" here is statistical research-speak meaning there is a correlation (w.r.t. positive empathy) but more studies are warranted (w.r.t. negative empathy). That is all.

Re: Acetaminophen vs. ibuprofen

#50
post #35

Earlier quoted context omitted.

Or 10 slightly larger ones edit: https://www.24pharma.nl/paracetamol-eg-1000mg-120-tabletten

I’ve pretty much only ever seen them sold at 500mg; are you regularly seeing them where you are sold in 1g form?

They are common in France, but not in such packages: There are restrictions that prevent you from buying more than than 8g/day (theoretically at least, I don't believe they are strictly applied in practice).
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