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Anti-aging injection regrows knee cartilage and prevents arthritis

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Re: Anti-aging injection regrows knee cartilage and prevents arthritis

#71

Post by mcswell »

IsTom wrote: post #56
chrisfosterelli wrote: post #38

Earlier quoted context omitted.

Among endurance athletes collagen supplements have become increasingly popular the past couple years -- from what I understand the evidence is kind of mixed though e.g. https://thefeed.com/products/pillar-performance-collagen-1?v...

I don't get what's the supposed mechanism of action here. Collagen is a hard to digest protein and it has to get digested to be processed and then it's no longer collagen. Why not just eat any other protein source instead?

I was going to say that too, thanks for beating me to it!

Re: Anti-aging injection regrows knee cartilage and prevents arthritis

#72

Post by mcswell »

Volundr wrote: post #5
weeksie wrote: post #4

in mice

Always a good call out, but also: > Human knee tissue collected during joint replacement surgeries also responded positively to the treatment. These samples, which include both the joint’s supporting extracellular scaffolding, or matrix, and cartilage-producing chondrocyte cells, began forming new cartilage that functioned normally.

Good, but what does it mean for tissue samples to function normally? Function as what?

Re: Anti-aging injection regrows knee cartilage and prevents arthritis

#73

Post by mcswell »

Anecdote for any runners reading this: I'm a 75 year old runner. (Some young runners might say I run at a jogger's pace, I just tell them to keep off my lawn.)

A couple decades ago, I stopped running on concrete or asphalt, and took up trail running, i.e. running on (mostly) dirt. It feels way easier than running on asphalt, much less on concrete. If you're skeptical that running on concrete or asphalt feels harder, give it a try. YMMV, but I'd bet you notice a difference.

And yes, I do fall sometimes, tripping over roots or rocks. But I recover quickly.

Re: Anti-aging injection regrows knee cartilage and prevents arthritis

#75

Post by dw_arthur »

linsomniac wrote: post #27

I have had fairly serious arthritis in my hips for close to a decade now. Cortizone shots directly into the joint have helped the worst of the flare-ups (limping on my way into the shot, having 0 pain walking out of it, lasting a year). 5+ years ago when I was looking for another injection, my PCP said "Well, time for a hip replacement." Now, for reasons I don't understand I think he was being way premature on that (…

This has been my experience with every sports of weightlifting injury I've had and I'm in my 40s. The body wants to heal or at least compensate in some way. Light activity is often better than rest. I've got a knee that is acting up a little bit but I think I've figured out how to keep it healthy while running.

Re: Anti-aging injection regrows knee cartilage and prevents arthritis

#76

Post by 8f2ab37a-ed6c »

elorant wrote: post #48
8f2ab37a-ed6c wrote: post #42

I would love this for some of my finger joints beat up from decades of typing.

Have you tried mechanical keyboards? They were a life saver for me. I can type more than 100k keystrokes/day without any pain whatsoever.

Yep. On a keyboard with 8 thumb cluster keys per side, and custom 35g switches to lower the force needed to actuate, that helped a lot, but still not enough to be pain-free. Unfortunately once the damage is done on certain joints you can only do so much short of not using those fingers at all. 30 years of hammering keys pretty hard eventually catch up to you.

Re: Anti-aging injection regrows knee cartilage and prevents arthritis

#77

Post by bikenaga »

Something similar was done in a sheep model:

"A bioactive supramolecular and covalent polymer scaffold for cartilage repair in a sheep model" - https://www.pnas.org/doi/10.1073/pnas.2405454121

"Abstract: Regeneration of hyaline cartilage in human-sized joints remains a clinical challenge, and it is a critical unmet need that would contribute to longer healthspans. Injectable scaffolds for cartilage repair that integrate both bioactivity and sufficiently robust physical properties to withstand joint stresses offer a promising strategy. We report here on a hybrid biomaterial that combines a bioactive peptide amphiphile supramolecular polymer that specifically binds the chondrogenic cytokine transforming growth factor β-1 (TGFβ-1) and crosslinked hyaluronic acid microgels that drive formation of filament bundles, a hierarchical motif common in natural musculoskeletal tissues. The scaffold is an injectable slurry that generates a porous rubbery material when exposed to calcium ions once placed in cartilage defects. The hybrid material was found to support in vitro chondrogenic differentiation of encapsulated stem cells in response to sustained delivery of TGFβ-1. Using a sheep model, we implanted the scaffold in shallow osteochondral defects and found it can remain localized in mechanically active joints. Evaluation of resected joints showed significantly improved repair of hyaline cartilage in osteochondral defects injected with the scaffold relative to defects injected with the growth factor alone, including implantation in the load-bearing femoral condyle. These results demonstrate the potential of the hybrid biomimetic scaffold as a niche to favor cartilage repair in mechanically active joints using a clinically relevant large-animal model."

Re: Anti-aging injection regrows knee cartilage and prevents arthritis

#78

Post by mancerayder »

mcswell wrote: post #73

Anecdote for any runners reading this: I'm a 75 year old runner. (Some young runners might say I run at a jogger's pace, I just tell them to keep off my lawn.) A couple decades ago, I stopped running on concrete or asphalt, and took up trail running, i.e. running on (mostly) dirt. It feels way easier than running on asphalt, much less on concrete. If you're skeptical that running on concrete or asphalt feels harder,…

I'd worry about sprained ankles on a false step or a slippery leaf-rock trap. Is there a technical approach to running in these conditions?

Re: Anti-aging injection regrows knee cartilage and prevents arthritis

#79

Post by nradov »

mcswell wrote: post #73

Anecdote for any runners reading this: I'm a 75 year old runner. (Some young runners might say I run at a jogger's pace, I just tell them to keep off my lawn.) A couple decades ago, I stopped running on concrete or asphalt, and took up trail running, i.e. running on (mostly) dirt. It feels way easier than running on asphalt, much less on concrete. If you're skeptical that running on concrete or asphalt feels harder,…

You're not wrong, but most of us don't live near a good dirt running trail so we have to drive to reach the trail head. When we have to squeeze in a run on workdays it becomes a choice between running on the street versus not running at all. Mud is also a problem for trail running in areas that get much rain.

Re: Anti-aging injection regrows knee cartilage and prevents arthritis

#80

Post by lifter3101 »

leechy wrote: post #66

Turns out the pain in my knee was a latent infection with staph aureus, forming small nubs under the skin. Debrided the skin, removing the nubs, applied 3% doyiciclin creme and pain is gone. This for a knee with 2 operations before and teo doctors saying I need a replacement. Doctors are mostly unhelpful idiots imho.

Glad to hear you’re feeling better! How did you find out the root cause and treatment?
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