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From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency

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Re: From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency

#81

Post by apple4ever »

jorvi wrote: post #72
philipkglass wrote: post #68

Earlier quoted context omitted.

This is not a cravings loss drug but largely a cravings management drug. Which is still pretty great but it saddles healthcare funding systems with an enormous burden for the next 20 years. Semaglutide goes off-patent in 2032 in the US, and in 2026 in Canada and China: https://journals.library.columbia.edu/index.php/stlr/blog/vi... https://www.ncbi.nlm.nih.gov/books/NBK602920/table/t03/

Wait, what? I thought these were extremely new drugs, only approved for a couple of years now.

No they have been on the market for decades, but only recently have been found to be of use to non-diabetics. That's why you are hearing about them much more.

Re: From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency

#82

Post by cjbgkagh »

mattgreenrocks wrote: post #73
cjbgkagh wrote: post #57

Earlier quoted context omitted.

Yeah, that's one of the reasons I waited for usage data is that I was pretty sure people with hEDS would have an overly strong reaction, and that did happen in my case and appears to have happened with other with hEDS. I started at 0.025mg (1/20th the 0.5mg starting dose at the time) and still got temporary gastroparesis which was indeed very uncomfortable. I had done long term fasting prior to semaglutide so I had t…

Wow. Glad it panned out for you.

Thanks, highly recommended. I forgot to answer, I don’t have MCAS but I do get PEM which I do believe is another form of allergic reaction. I do like to eat histamine inducing foods and I wonder if has kept MCAS desensitized.

Re: From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency

#83

Post by apple4ever »

francisofascii wrote: post #19
blakesterz wrote: post #2

“We think that, by modulating cerebrospinal fluid pressure and reducing intracranial venous sinuses compression, these drugs produce a decrease in the release of calcitonin gene-related peptide (CGRP), a key migraine-promoting peptide”, Dr Braca explained. “That would pose intracranial pressure control as a brand-new, pharmacologically targetable pathway.” I'm not sure I understand what that means, but I wonder if th…

I wonder if the drug itself reduces CGRP or perhaps the altered diet is the cause.

I was wondering the same thing. Might be a mix depending on person.

Re: From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency

#84

Post by deegles »

ascorbic wrote: post #54
neom wrote: post #4

Is there any good consensus on what the deal is with this drug yet? I don't know how to think about GLP-1. In the headlines it seems like every month it's a miracle cure for something new, yet we don't really understand it? But it seems like just generally...everyone, including me, would benefit from being on it...? The whole thing makes me uneasy but I'm not exactly sure why outside of it seems weird to have one dru…

There are currently several hypotheses. Some say that it's just because it helps you lose weight, and obesity increases the risk of so many things. However while this is true, there are lots of examples where there are effects even when you control for weight loss. One of the more interesting theories is that it's down to their anti-inflammatory effects, because chronic inflammation is linked to so many conditions.

but are the GLP-1s reducing inflammation or is it a side effect of the reduced caloric intake? does it matter?

Re: From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency

#86

Post by rootusrootus »

apple4ever wrote: post #79
jorvi wrote: post #58

Earlier quoted context omitted.

The Alzheimer """cure""" claim was already disproven by another study. Aside from that, the people who stop taking GLP, 75% gain 50-75% of their bodyweight back and lose all concomitant cardiovascular, cancer etc. risk benefits. No research out on, say, alcoholism yet, but I'd hazard a guess the results are the same. This is not a cravings loss drug but largely a cravings management drug. Which is still pretty great…

> the people who stop taking GLP, 75% gain 50-75% of their bodyweight back and lose all concomitant cardiovascular, cancer etc. risk benefits. I don't think that framing is right, from another study: * 17.5% maintained 75+% of their weight loss * 25% maintained 50-75% of their weight loss * 23% maintained 25-50% of their weight loss * 24% maintained 0-25% of their weight loss At least 75% (possibly more!) maintained…

> I don't understand this desire to say "people should suffer!" instead of taking something that helped them.

Religion is my assumption. Or human nature more generically. Gluttony is one of the seven deadly sins in Christianity. So it is a moral issue for many people.

Re: From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency

#87

Post by throwaway2037 »

didibus wrote: post #74
neom wrote: post #4

Is there any good consensus on what the deal is with this drug yet? I don't know how to think about GLP-1. In the headlines it seems like every month it's a miracle cure for something new, yet we don't really understand it? But it seems like just generally...everyone, including me, would benefit from being on it...? The whole thing makes me uneasy but I'm not exactly sure why outside of it seems weird to have one dru…

It's too soon to really know the downsides. Statins for example only recently are better understood and there's a lot more downsides we know about now. It's likely going to be true for GLP-1 as well.

The downsides of statins? This is the first I heard about it.

Google AI tells me:

    > The main downsides of statins include muscle pain, weakness, and fatigue, and a small increased risk of developing type 2 diabetes.
Are there others?

Re: From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency

#88

Post by throwaway2037 »

llm_nerd wrote: post #9
neom wrote: post #4

Is there any good consensus on what the deal is with this drug yet? I don't know how to think about GLP-1. In the headlines it seems like every month it's a miracle cure for something new, yet we don't really understand it? But it seems like just generally...everyone, including me, would benefit from being on it...? The whole thing makes me uneasy but I'm not exactly sure why outside of it seems weird to have one dru…

GLP-1 is a naturally occurring hormone regulating blood sugar, satiety, and gastric emptying. Some people simply don't have enough naturally (which can be a result of diet composition and lifestyle -- there are diet and behaviour modifications to increase your natural production) and artificial supplementation is beneficial. The overwhelming benefits from GLP-1 are courtesy of weight loss and better blood sugar contr…

I need to ask: What is it with HN attracting the "inflammation explains everything" crowd whenever there is a discussion about medical topics? I don't understand it. Is there any hard science behind all these explanations of phenom via the inflammation pathway? Or is this just another seed oil conspiracy theory?

Re: From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency

#89

Post by array_key_first »

throwawaysleep wrote: post #27
mikhailt wrote: post #11

Earlier quoted context omitted.

Nobody understands why it all helps, they just noticed it does work for something, quickly pushed it to the market first to get patents and get all the profits from it before generics + derivatives hit their pockets. Now, everyone is studying it because there's all new funding coming in for it and finding other versions of it that they can profit off it. Nobody knows what migraine really is, so this isn't a surprise…

> Keep in mind that a lot of the benefits go away once patients come off GLP-1 All medicines taken for chronic conditions as this way.

Right, this mentality peeves me a little bit.

The idea that drugs shouldn't be taken forever just doesn't make any sense. There are plenty of forever diseases, naturally those should require forever drugs.

Re: From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency

#90

Post by array_key_first »

didibus wrote: post #74
neom wrote: post #4

Is there any good consensus on what the deal is with this drug yet? I don't know how to think about GLP-1. In the headlines it seems like every month it's a miracle cure for something new, yet we don't really understand it? But it seems like just generally...everyone, including me, would benefit from being on it...? The whole thing makes me uneasy but I'm not exactly sure why outside of it seems weird to have one dru…

It's too soon to really know the downsides. Statins for example only recently are better understood and there's a lot more downsides we know about now. It's likely going to be true for GLP-1 as well.

The downside of statins are more or less made up by people who want to convince you that you can prevent heart disease by taking their magic supplement (which isn't like other supplements, this one really works!)

Either that or out-of-touch fitness people who push overly restrictive diets and workout plans. Which work, but actually no they don't, because nobody with a sane mind would want to stick to them. And now you're back at square one but you also have a disdain for food and exercise.

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