I thought this was already known? I can’t recall exactly but there was some research pointing to SSRIs in general as not being particularly effective at all. They were just hyped a lot and became mainstream.
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Prozac 'no better than placebo' for treating children with depression, experts
121–130 of 561 posts
Re: Prozac 'no better than placebo' for treating children with depression, experts
#122From the article: > They can also increase suicidal ideation. A very close family member committed suicide, after Prozac dosage adjustments made his brain chemistry go haywire. This happened 30 years ago, and it has been known to us that Prozac can cause this, since then. The Guardians headline is way, way understating the real situation here.
I also had a close family member who committed suicide shortly after going on Prozac -- this also happened nearly 30 years ago. His young son later went on Prozac himself (several months after his fathers suicide) and immediately started demonstrating bizarre disinhibited anti-social behavior (e.g., damaging property, stealing from friends, etc). He was immediately yanked off Prozac when he started articulating his own thoughts of suicide. The bizarre anti-social behavior improved after discontinuing Prozac.
For some people, Prozac is a very dangerous drug. It is fully deserving of its FDA black label warning (which it didn't have 30 years ago).
Re: Prozac 'no better than placebo' for treating children with depression, experts
#123I was very young when my mom started Prozac but do remember how angry and sad she was before compared to after. Years later there was a time when me and my sister noticed our mom was acting a bit strange -- more snappish and irritable than usual, and she even started dressing differently. Then at dinner she announced proudly that she had been off Prozac for a month. My sister and I looked at each other and at the sam…
> my 7-year-old son just started half that dose
This is horrifying.
Re: Prozac 'no better than placebo' for treating children with depression, experts
#124I was very young when my mom started Prozac but do remember how angry and sad she was before compared to after. Years later there was a time when me and my sister noticed our mom was acting a bit strange -- more snappish and irritable than usual, and she even started dressing differently. Then at dinner she announced proudly that she had been off Prozac for a month. My sister and I looked at each other and at the sam…
Your anecdote has nothing to do with whether it's better than a placebo or not.
His anecdote explicitly mentions the possibility of it being a placebo.
Re: Prozac 'no better than placebo' for treating children with depression, experts
#125I thought this was already known? I can’t recall exactly but there was some research pointing to SSRIs in general as not being particularly effective at all. They were just hyped a lot and became mainstream.
Here the context is for children, not in general.
Re: Prozac 'no better than placebo' for treating children with depression, experts
#126I was very young when my mom started Prozac but do remember how angry and sad she was before compared to after. Years later there was a time when me and my sister noticed our mom was acting a bit strange -- more snappish and irritable than usual, and she even started dressing differently. Then at dinner she announced proudly that she had been off Prozac for a month. My sister and I looked at each other and at the sam…
> my 7-year-old son just started half that dose This is horrifying.
Why? If a kid has diabetes, would it be horrifying to treat it? Why would it be different for a neurochemistry issue that makes the same kid tired and sad all the time?
Re: Prozac 'no better than placebo' for treating children with depression, experts
#127A post on HN a couple years ago discussed research showing antidepressants only work for about 15% of patients: https://news.ycombinator.com/item?id=37671529
The thing is, they work very well for that 15%. I suspect the eventual conclusion will be that depression is a syndrome with multiple causes rather than a single condition, and SSRIs treat one of the causes.
Edit: Mark Horowitz is one of the authors of both studies.
Re: Prozac 'no better than placebo' for treating children with depression, experts
#128I was very young when my mom started Prozac but do remember how angry and sad she was before compared to after. Years later there was a time when me and my sister noticed our mom was acting a bit strange -- more snappish and irritable than usual, and she even started dressing differently. Then at dinner she announced proudly that she had been off Prozac for a month. My sister and I looked at each other and at the sam…
> my 7-year-old son just started half that dose This is horrifying.
Why?
Re: Prozac 'no better than placebo' for treating children with depression, experts
#129Earlier quoted context omitted.
You really have to unpack "detox inefficiency" because even a google search comes back with nothing.
When your normal lymphatic processes (and glymphatic processes) are slowed, or near-halted.
Is there a known correlation between lymphedema and depression?
Re: Prozac 'no better than placebo' for treating children with depression, experts
#130Earlier quoted context omitted.
> my 7-year-old son just started half that dose This is horrifying.
Why? If a kid has diabetes, would it be horrifying to treat it? Why would it be different for a neurochemistry issue that makes the same kid tired and sad all the time?
Because the problem's not a "neurochemistry issue" (that theory's been debunked and the "chemicals" in play have never been known), and the solution is "no better than placebo."