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Prozac 'no better than placebo' for treating children with depression, experts

theguardian.com

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Re: Prozac 'no better than placebo' for treating children with depression, experts

#91
post #63
post #62

Earlier quoted context omitted.

[flagged]

This gets even more interesting when you realize many SSRIs are antibacterials.

It gets less interesting when one notices that social animals are much more prone to depression.

Inflammation and depression are linked. Infection causes inflammation. It doesn’t follow that depression is caused by infection.

Re: Prozac 'no better than placebo' for treating children with depression, experts

#92
post #43

I can't bring myself to try an SSRI. I just cannot do it. I've got a prescription for an NDRI on my desk, and I still won't take it. I am not anti-psychiatry either. I take psychiatric medication for a different condition already. But something about anti-depressants just doesn't sit well with me. As crazy as it may sound, I think a lot of my depression stems from living a life that is not true to myself and due to c…

> *depression is just a symptom of my situation and not some true disorder+

There is a great Bojack Horseman episode in which Diane struggles with the idea of taking antidepressants for similar reasons.

If it’s depression, that’s closer to allergies, chronic inflammation or a broken bone healed wrong than vomiting after food poisoning.

Re: Prozac 'no better than placebo' for treating children with depression, experts

#93

Maybe SSRIs work for some, but Paxil gave me serotonin syndrome and Prozac made my mom psychotically homicidal. I've tried every SSRI titrating on and off (except Paxil), but they all caused deal-breaking side-effects.

Sorry to hear it. I believe it's best practice to try different types of drugs (SNRI, atypical/Bupropion, etc).

Re: Prozac 'no better than placebo' for treating children with depression, experts

#94
post #43

I can't bring myself to try an SSRI. I just cannot do it. I've got a prescription for an NDRI on my desk, and I still won't take it. I am not anti-psychiatry either. I take psychiatric medication for a different condition already. But something about anti-depressants just doesn't sit well with me. As crazy as it may sound, I think a lot of my depression stems from living a life that is not true to myself and due to c…

> not some true disorder there's a tool on your desk that might help you solve your problem; what does it matter if the problem is an "appropriate response of your body"? so is pain/anxiety/diarrhea

> stems from living a life that is not true to myself and due to countless failed attempts to be someone I cannot never be.

If this is their mindset, they might benefit from CBT more than medication.

I'm not against SSRI at all. But after taking them for a few months in my 20's, and experiencing how terrible the withdrawal symptoms are when stopping, I'd be very hesitant to ever start up on them again. I remember having to open up the lowest dose pill capsule and splitting the dose into very tiny increments to be able to wean off completely.

Re: Prozac 'no better than placebo' for treating children with depression, experts

#95
post #82
post #67

Earlier quoted context omitted.

Do you have a plan to get her off, or is she on the maintenance drug for life? It's too early to say. Obviously the idea is to get her off it if possible. SSRIs never help because of boosting serotonin. That's a hell of a claim, which could use some evidence.

> > SSRIs never help because of boosting serotonin. > That's a hell of a claim, which could use some evidence. My experience with the chatbots is that they start with the conventional marketing tropes, but if you ask pointed questions they'll dig into the actual research. This thread started with a generic question about why ECT seemed to help some patients. It had a really good reasoning about why SSRIs are still th…

The chatbot is great as a first-line of research for many things, but something like this needs to be backed up by actual research to make a concrete claim. It will absolutely fabricate falsehoods or misrepresent truths based on an unknown number of stochastic factors behind any response. Shame on your for propagating a bunch of mumbo-jumbo that every reader must go verify for themselves if they want to substantiate or refute your claim - in response to a request for substantiation!

Re: Prozac 'no better than placebo' for treating children with depression, experts

#96
post #23

Our 11 year old daughter was seriously depressed recently. N=1, but fluoxetine was life changing (and potentially life saving) for her, at least.

Placebo can be life changing

Absolutely. These random namedrops of drugs are irritating. People respond to different psychiatric medications in wilddly different ways. And actually, the majority do not respond at all. Throwing a random name of some random medication helps absolutely nobody. It will just make some desperate people seek "this one drug" that they heard about on the internet.

Re: Prozac 'no better than placebo' for treating children with depression, experts

#97
post #63

Earlier quoted context omitted.

This gets even more interesting when you realize many SSRIs are antibacterials.

It gets less interesting when one notices that social animals are much more prone to depression. Inflammation and depression are linked. Infection causes inflammation. It doesn’t follow that depression is caused by infection.

Correct.

It’s caused by inflammation,

one of the causes being: detox inefficiency.

Re: Prozac 'no better than placebo' for treating children with depression, experts

#98
post #88
post #62

Earlier quoted context omitted.

[flagged]

Depression is likely to have many possible underlying causes. It’s a description of a persistent set of symptoms not necessarily any specific biological process.

Correct.

and one of the leading causes is what I described.

Re: Prozac 'no better than placebo' for treating children with depression, experts

#99
post #43

I can't bring myself to try an SSRI. I just cannot do it. I've got a prescription for an NDRI on my desk, and I still won't take it. I am not anti-psychiatry either. I take psychiatric medication for a different condition already. But something about anti-depressants just doesn't sit well with me. As crazy as it may sound, I think a lot of my depression stems from living a life that is not true to myself and due to c…

Depression is almost never caused by actual life circumstance - just by your response and usually a delayed response.

Also you should try your SSRI prescription. They really aren't very strong drugs. You might get mild relief or if you're like me and the majority of people you will see no effect whatsoever. It's worth a try anyway. You won't get "high" or "dull" or any of that nonsense. At best it will lift your mood a bit. But more often than not, just won't do anything.

Re: Prozac 'no better than placebo' for treating children with depression, experts

#100
post #97

Earlier quoted context omitted.

It gets less interesting when one notices that social animals are much more prone to depression. Inflammation and depression are linked. Infection causes inflammation. It doesn’t follow that depression is caused by infection.

Correct. It’s caused by inflammation, one of the causes being: detox inefficiency.

> It’s caused by inflammation

No, it’s not. Depression can be influenced by inflammation.

This thread is a good example of the GIGO pitfalls that researching with chatbots entails.

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