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GLP-1 drugs linked to lower death rates in colon cancer patients

today.ucsd.edu

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Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#91

Post by ck2 »

isoprophlex wrote: post #26
exabrial wrote: post #21

Earlier quoted context omitted.

Private people invested a lot of money to develop this and get it through testing. Allowing them to reap the benefits from their investment for a limited time is just fine. It's not people couldn't also: Diet, exercise, choose veggies, eat more fiber, etc

"Sorry bro gonna let you die because, muh investments, you see" Your closing remark is overly simplistic and offers a contradiction: if those things would work for these obese people, they wouldn't need GLPs.

just want to point out it's not just for obesity

GLP-1 has been demonstrated to even cure some types of long-covid in some people in some cases

and various other diseases

but it's priced way out of reach even for micro-doses until it becomes generic

so all those cases suffer until 2030, if they make it that far, five years is a long time

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#92

Post by fgimenez »

surfsvammel wrote: post #59

I am on GLP-1 (very low dose), and I’ve found that it seems to help me moderate my alcohol consumption as well. Maybe some thing like that could also be contributing to the effect.

They have a lot of anecdotal, observational, and emerging RCT evidence on their effects on substance consumption and abuse.

The biggest effect and best tested is on alcohol use disorder. Mechanistically we don't know if it's through some complex reward mechanism, or something simpler like "alcohol is a calorie and you consume fewer calories." The JAMA study showed that GLP-1 reduce Heavy Drinking Days (>2 drinks/day), but did not reduce overall drinking days. This would imply the simple mechanism -> it's hard to drink a lot of calories even if you do enjoy a drink.

More anecdotal evidence showing this effect in opiates, but nothing in an RCT yet.

So far, nothing has worked in stimulants. Cocaine and Meth abuse are insanely difficult to manage therapeutically right now.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#94

Post by trallnag »

cyrusradfar wrote: post #81
jl6 wrote: post #22

> However, the study authors emphasize that more research is needed to confirm these mechanisms and determine whether the survival benefit observed in this real-world analysis represents a direct anti-cancer effect or an indirect result of improved metabolic health Given it’s an observational study, I would bet on the latter. It’s really hard to know you’ve controlled for all confounding factors, and there’s a strong…

Agreed. I'm a big fan of intermittent and water fasting. Have seen things in my blood work that doctors would require me on meds to reverse. Outside of that, I can't speak to the positive impacts on my mood, and general ability to focus. The simplest solution to a lot of problems is consuming less with the assumption that, most of us (maybe not you), have a lot of spare energy sitting around. A lie that we don't unle…

Awesome insight. It's not the disability I have, it's that I have never tried healing by fasting. Of course. Because my body was always busy trying to eat food instead of fixing and regrowing all the malformed tissue. Because that's how it works. When a person without legs starts to fast, the legs will suddenly develop.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#95

Post by itchyouch »

cyrusradfar wrote: post #81
jl6 wrote: post #22

> However, the study authors emphasize that more research is needed to confirm these mechanisms and determine whether the survival benefit observed in this real-world analysis represents a direct anti-cancer effect or an indirect result of improved metabolic health Given it’s an observational study, I would bet on the latter. It’s really hard to know you’ve controlled for all confounding factors, and there’s a strong…

Agreed. I'm a big fan of intermittent and water fasting. Have seen things in my blood work that doctors would require me on meds to reverse. Outside of that, I can't speak to the positive impacts on my mood, and general ability to focus. The simplest solution to a lot of problems is consuming less with the assumption that, most of us (maybe not you), have a lot of spare energy sitting around. A lie that we don't unle…

An interesting FYI is a comment made by Peter Attia on his podcast.

He had a patient with metabolic markers that were not improving and they had exhausted all the typical avenues. Presumably they were things like weight loss.

They put the patient on GLP-1 but injected into the thighs (or butt, I don't recall) for the metabolic benefits without the hunger blunting effects.

It seems like GLP1, even in skinny patients (implied by Attia in this particular case), has metabolic benefits.

The longevity community seems to be hinting that there may be geroprotective aspects of GLp1 as well, so we may be looking at the benefits beyond weight loss for metabolism.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#96

Post by xtracto »

bicx wrote: post #2

Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.

Several members of my family are into glp-1 both for glucose control and for weight loss. Taking different brands (wegovy, ozempic and others.) They all mention.th terrible secondary effects when you eat something "forbidden" (tacos, cake or icecream e.g.) .

  Also It causes constipation apparently,  which for most of them is not that much of an issue, but given that I've IBS-C, I'm happy to not have to take it.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#97

Post by m463 »

bicx wrote: post #2

Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.

I wonder if you could ask: are there downsides to losing weight?

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#98

Post by kube-system »

ck2 wrote: post #90
kube-system wrote: post #75

Earlier quoted context omitted.

Compounded GLP-1s are still floating around in the US

if you saw the 60 Minutes on compounding pharmacies, which are completely unregulated and never inspected, and sometimes contaminate products out of lack of care/repercussions you'd never touch a compounded pharmacy product ever again people have died from contamination

Compounding pharmacies are regulated by section 503 of the FD&C act, and also subject to inspection.

Are you referring to the fact that the FDA does not inspect all facilities because they have limited resources? This applies to pharmaceutical companies as much as it does to compounders. If you think the FDA posts inspectors at every pharmaceutical company in India, you’d be wrong.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#99

Post by MangoToupe »

m463 wrote: post #97
bicx wrote: post #2

Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.

I wonder if you could ask: are there downsides to losing weight?

Hey some of us struggle to eat enough and/or remember to eat in the first place

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#100

Post by MangoToupe »

exabrial wrote: post #21
ck2 wrote: post #15

no GLP-1 generics until 2030 lots of people will miss out on benefits, like oh preventing death our drug system is weird

Private people invested a lot of money to develop this and get it through testing. Allowing them to reap the benefits from their investment for a limited time is just fine. It's not people couldn't also: Diet, exercise, choose veggies, eat more fiber, etc

> Allowing them to reap the benefits from their investment for a limited time is just fine.

Or we could just move to a sane economic system where we don't have to beg the rich/reward people for having money

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