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Ozempic shows anti-aging effects in trial

trial.medpath.com

21–30 of 868 posts

Re: Ozempic shows anti-aging effects in trial

#21

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

Naturally skinny people hate Ozempic for the same reason I know many talented engineers who hate AI coding.

It is not fun when your superpower becomes a commodity.

Re: Ozempic shows anti-aging effects in trial

#24

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

The drug companies are very good at making new drugs with high profit potential look better than they are. I'm worried semaglutides are another fen-phen, Vioxx, Quaaludes, Trovafloxacin or OxyContin. One thing to watch for is effect size: how big of an anti-aging effect does Ozempic confer relative to other good interventions? Were the subjects doing other solid anti-aging interventions like the Fasting Mimicking Die…

I think that's a completely reasonable concern to have, it doesn't seem to be the case wrt obesity but for the myriad of other potential effects it's important to keep in mind.

Re: Ozempic shows anti-aging effects in trial

#25

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

[deleted]

Re: Ozempic shows anti-aging effects in trial

#26

This is specifically a study on people with HIV-associated lipohypertrophy, which is associated with accelerated aging. Not clear what this would mean for people generally.

People on ozempic certainly look more like the crypt keeper than a younger version of themselves. You lose all that buccal fat that defines your young adult face.

Re: Ozempic shows anti-aging effects in trial

#27

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

Many people (will only speak to America), view being fat as a literal moral failing. Gluttony or overeating are not the sin, but being fat. (From that perspective:)a miracle cure that allows someone to stop being fat is like an indulgence (in the Roman Catholic sense). It’s a cheat, a shortcut that allows the unworthy to reach a state they do not deserve. My opinion is to wait long enough to validate there are no lon…

>My opinion is to wait long enough to validate there are no long term harms,

What's your threshold on that? How many years is "long enough"? Trying to calibrate my own sense of risk.

Re: Ozempic shows anti-aging effects in trial

#28

Earlier quoted context omitted.

The drug companies are very good at making new drugs with high profit potential look better than they are. I'm worried semaglutides are another fen-phen, Vioxx, Quaaludes, Trovafloxacin or OxyContin. One thing to watch for is effect size: how big of an anti-aging effect does Ozempic confer relative to other good interventions? Were the subjects doing other solid anti-aging interventions like the Fasting Mimicking Die…

I think that's a completely reasonable concern to have, it doesn't seem to be the case wrt obesity but for the myriad of other potential effects it's important to keep in mind.

I'm not even ready to concede that it is a good weight-loss drug -- but then I haven't really investigated much, so I'm just repeating what I heard from researcher Ben Bikman and maybe other researchers. I heard that most people choose to discontinue it after 4 or 5 years or less, regain most or all of the weight, then refuse to go back on it.

Re: Ozempic shows anti-aging effects in trial

#29

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

[deleted]

Re: Ozempic shows anti-aging effects in trial

#30

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

I think there's a justifiable fear/dread when things that used to demonstrate virtues no longer do so.

For instance, being in shape used to (usually) demonstrate discipline. Art or music used to demonstrate attention to craft and practice. Knowledge demonstrated time devoted to study.

This isn't to say that the world is worse with these advances (I'd be hopeless without search engines, and I am grateful that people get to live longer and healthier with semaglutide), but I think a little bit of mourning is understandable: what used to be the fruits of hard work are now a dime-a-dozen commodity.

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