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Sleep all comes down to the mitochondria

science.org

151–160 of 325 posts

Re: Sleep all comes down to the mitochondria

#151
post #42

Earlier quoted context omitted.

Would a hyphen be correct here instead of the comma? Or do you start a new sentence?

It's more about the 2 missing apostrophes and the 2 missing capital letters.

youre on the internet boi, go live in a dictionary if you want proper english

Re: Sleep all comes down to the mitochondria

#152

Earlier quoted context omitted.

> If you need oxygen, then you need sleep! Do plants sleep? Don't some insects, like flies, live without any sleep?

Plants breathe out oxygen, like we breathe out the other one.

That's true for photosynthesis but don't they still have oxygen respiration (i.e. oxidizing sugar for energy?)

Re: Sleep all comes down to the mitochondria

#153
post #88
post #66

Sleep is super important. I’ve seen too many workaholic types that barely sleep. So many of these folks end up with serious issues later in life.

One best things about getting laid off from work is that one get to sleep as long as one want in the morning!

Or binge watch the entire Walking Dead series in a month

Re: Sleep all comes down to the mitochondria

#154
post #5

So the ancient mystery of why we need sleep might have just been answered. The paper shows that cell‑autonomous mild uncoupling in Drosophila sleep‑inducing neurons -- via Ucp4A/Ucp4C -- keeps the flies awake by lowering mitochondrial Δp and therefore electron leak. This suggests a biochemical rationale for sleep -- which is postponed by the uncoupler. That form of pharmacological manipulation is also a very local in…

> So the ancient mystery of why we need sleep might have just been answered. I would be very surprised if sleep would serve only one purpose. In complex interconnected systems you usually don't get far with monocausal explanations.

When I'm awake for a very long time (32hrs+) it feels like there is poison built up in my mind, then sleep clears it up/feel better.

Also if you lift in the mornings you feel lack of sleep/alcohol sleep disruption.

Re: Sleep all comes down to the mitochondria

#156
post #140

Earlier quoted context omitted.

I don't think they meant "Modern" sleep. I think they meant "Only brief periods of highly energetic activity before returning to the usual activities were precursors to our modern consciousness/wakefulness"

That is also what I am referring to. Energetic activity is required to live and to reproduce, those are the normal activities. An active creature may have evolved a state of dormancy for various reasons, but there was never an organism in a state of pure dormancy.

Do sponges sleep?

Re: Sleep all comes down to the mitochondria

#157
post #140

Earlier quoted context omitted.

I don't think they meant "Modern" sleep. I think they meant "Only brief periods of highly energetic activity before returning to the usual activities were precursors to our modern consciousness/wakefulness"

That is also what I am referring to. Energetic activity is required to live and to reproduce, those are the normal activities. An active creature may have evolved a state of dormancy for various reasons, but there was never an organism in a state of pure dormancy.

A seed?

Re: Sleep all comes down to the mitochondria

#158
post #132

There is a difference between being physically tired as a result of metabolic effort, and being mentally tired/sleepy. Even if you lie on the couch all day you will still be tired come night time, and can not survive for long if deprived of sleep. It seems the mental need for sleep comes from the brain needing offline (no sensory input) downtime for "housekeeping" activities - perhaps essentially organizing and filin…

the brain burns more power when doing mentally exhausting tasks than at idle, so it makes sense to have to recharge mitochondria in there. (the 'more' is not huge, like 5% - so it also makes sense to be tired after a lazy day I guess)

But we're sleepy every night regardless of how much or how little we have done mentally during the day. Doing more work (mental or physical) than usual will make us feel more tired, but the basic need for the 24hr sleep cycle is there regardless.

We fundamentally sleep at night based on circadian rhythm (evolved from earth's 24hr day), not based on activity level. We do also feel tired after a strenuous activity, but recover after a little rest and nutrition - this doesn't appear to be the same thing as the fundamental need for sleep.

Re: Sleep all comes down to the mitochondria

#159
post #155

> If you need oxygen, then you need sleep! Would this also correlate with the desire to yawn? I always heard that yawning was a response to needing more oxygen.

It has nothing to do with oxygen; Yawning is caused by other people yawning in the vicinity.

Of course not. Sympathy yawning is a thing of course, but have you never yawned by yourself with no one around?

Re: Sleep all comes down to the mitochondria

#160

Could this be an explanation for why people who go without sleep for long enough eventually just die? The Guinness Book of World Records doesn't accept records on staying awake for the same reason they don't accept records for the longest game of Russian Roulette.

While it is true that Guiness stopped keeping track of records of staying awake for health reasons, people with severe sleep deprivation ends up being psychotic and admitted to psychiatric care and administered sleep inducing drugs. So, lack of sleep is not something you die from short term. Long term (years, decades) short sleep is associated with higher all cause mortality risk though.
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