131–140 of 325 posts
It seems the mental need for sleep comes from the brain needing offline (no sensory input) downtime for "housekeeping" activities - perhaps essentially organizing and filing away the day's short-term memories.
There is a difference between being physically tired as a result of metabolic effort, and being mentally tired/sleepy. Even if you lie on the couch all day you will still be tired come night time, and can not survive for long if deprived of sleep. It seems the mental need for sleep comes from the brain needing offline (no sensory input) downtime for "housekeeping" activities - perhaps essentially organizing and filin…
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That's almost exactly what people said about the appetite -- about the biochemical pathways which govern hunger, which are known to be massively redundant and overlapping. But then Ozempic was released and it turned out there was a shortcut after all. Which is not to say that such things are necessarily "healthy" or desirable, just that you can't rule out that biochemically-modifiable characteristics, however complex…
And exactly as I said, Ozempic does more harm in the long run.
So the ancient mystery of why we need sleep might have just been answered. The paper shows that cell‑autonomous mild uncoupling in Drosophila sleep‑inducing neurons -- via Ucp4A/Ucp4C -- keeps the flies awake by lowering mitochondrial Δp and therefore electron leak. This suggests a biochemical rationale for sleep -- which is postponed by the uncoupler. That form of pharmacological manipulation is also a very local in…
I'm curious how the few famous people that do not sleep at all, what's going on in their biochemestry? I don't mean celebrities, there are a few people who became famous because they do not sleep. They hold 2 complete careers, one during the day and one at night to keep from getting bored.
Earlier quoted context omitted.
That's almost exactly what people said about the appetite -- about the biochemical pathways which govern hunger, which are known to be massively redundant and overlapping. But then Ozempic was released and it turned out there was a shortcut after all. Which is not to say that such things are necessarily "healthy" or desirable, just that you can't rule out that biochemically-modifiable characteristics, however complex…
And exactly as I said, Ozempic does more harm in the long run.
Increasing the count and efficiency of mitochondria is gonna be a big deal. ME/CFS is caused by these organelles not working as they should.
[1]: https://docs.google.com/spreadsheets/u/1/d/1ZKl5Me4XwPj4YgJC...
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There definitely was never a life form which exclusively slept - all the critical parts of life require being awake. Life that didn't sleep, however, is possible.
Maybe not 'exclusively' slept, but koalas[1] sleep for a majority of the day (16-20 hours) in order to digest highly toxic eucalyptus leaves which constitute the main portion of their diet. [1] https://en.wikipedia.org/wiki/Koala
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It was applicable to all neural networks, not just LLMs. Can we say that after ChatGPT's release in 2022, now antitech bros think everything is about LLMs specifically?
The statement was "AI frenzy almost convinced me that sleep was the training of our neural network with all the prompts of the day." Prompts are specific to LLMs. Most neural networks don't have prompts. Additionally, prompts happen during LLM inference, not LLM training. There are many non-technical people who claim they have experience "training" LLMs, when they are just an end user who added a lot of tokens to the…
It is pretty common during the fine-tuning phase.
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There definitely was never a life form which exclusively slept - all the critical parts of life require being awake. Life that didn't sleep, however, is possible.
I don't think they meant "Modern" sleep. I think they meant "Only brief periods of highly energetic activity before returning to the usual activities were precursors to our modern consciousness/wakefulness"