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I wonder how this relates to sleep apnea, as in that state you sleep more the less oxygen you get. By the way, many people who don't think they have it yet feel tired during the day or simply feel like they need more sleep should get tested for it, as it's not just a problem for the obese.
Earlier quoted context omitted.
What would happen to the main and brain with "Healthy" wakefulness promoting drugs .
Probably nothing initially. Then over years of us and accumulated data, people will realize that they can't game a complex system that the body needs like sleep with a simple drug, and those "healthy" wakefulness drugs will either be banned or face lots of controversy.
But then Ozempic was released and it turned out there was a shortcut after all.
Which is not to say that such things are necessarily "healthy" or desirable, just that you can't rule out that biochemically-modifiable characteristics, however complex, have "one simple trick!" you can use to attain a desired end.
Given its role in energy transfer, does this suggest creatine might be a good supplement for improving sleep?
That's a bizarre coincidence. For the past few days I've run across a bunch of accounts of people taking more creatine than suggested (10-20g a day). They seem to all talk about how it makes them work better during sleep deprivation. So the answer seems like it helps.
So the ancient mystery of why we need sleep might have just been answered. The paper shows that cell‑autonomous mild uncoupling in Drosophila sleep‑inducing neurons -- via Ucp4A/Ucp4C -- keeps the flies awake by lowering mitochondrial Δp and therefore electron leak. This suggests a biochemical rationale for sleep -- which is postponed by the uncoupler. That form of pharmacological manipulation is also a very local in…
How far away are we from making this a pill? So we can stay up 18 hours a day, or something. Any estimates. Any idea what foods or current methods, to trigger the same mechanism?
https://www.nature.com/articles/s41586-025-09261-y
Not an expert in this area, but the essay feels a bit like an oversimplification. Not only is this in flies, but I wasn't entirely convinced this isn't about rest rather than sleep per se. It's a cool paper, interesting to read and read about, but my hunch is there's more steps in the chain, and am not sure it will replicate in humans or even mammals. But maybe I'll be wrong.
I wonder how this relates to sleep apnea, as in that state you sleep more the less oxygen you get. By the way, many people who don't think they have it yet feel tired during the day or simply feel like they need more sleep should get tested for it, as it's not just a problem for the obese.
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Earlier quoted context omitted.
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I said you sleep more the less oxygen you get, not the converse (ie, because you get less oxygen, you sleep more). And it is a factual statement that obese people are likelier to have sleep apnea, it is not a "stigma" and there is nothing wrong in suggesting that people who aren't in that category get tested too, don't try to find things to get offended by.
Earlier quoted context omitted.
Probably nothing initially. Then over years of us and accumulated data, people will realize that they can't game a complex system that the body needs like sleep with a simple drug, and those "healthy" wakefulness drugs will either be banned or face lots of controversy.
That's almost exactly what people said about the appetite -- about the biochemical pathways which govern hunger, which are known to be massively redundant and overlapping. But then Ozempic was released and it turned out there was a shortcut after all. Which is not to say that such things are necessarily "healthy" or desirable, just that you can't rule out that biochemically-modifiable characteristics, however complex…