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Ageing accelerates around age 50 ― some organs faster than others

nature.com

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Re: Ageing accelerates around age 50 ― some organs faster than others

#131

Post by dotancohen »

csallen wrote: post #39
NoOn3 wrote: post #11

Earlier quoted context omitted.

Maybe. But why in this case do we not see bugs and failures in this program, i.e. no one lived 5 times more than the average or did not live forever at all, for example? I'm not making a statement, just a guess.

Lots of models could explain this. For example, let's say it's not just one program, but thousand of programs running in your body, trying to get you to age or die. The chances that all of them bug out would be astronomically low.

But there have been astronomically high qualities of humans produced, none of which have shown this phenomenon.

Re: Ageing accelerates around age 50 ― some organs faster than others

#132

Post by exe34 »

JKCalhoun wrote: post #81
exe34 wrote: post #7

Mine started late-thirties. Stomach doesn't handle spices as it used to. Any bravery at dinner time means poor sleep and tiredness for a day or two. Bumps/strained things take days to stop hurting.

No harm in adding probiotics to your daily diet. Kefir, Kombucha, Kimchi are a few.

Will look into that thanks!

Re: Ageing accelerates around age 50 ― some organs faster than others

#133

Post by drgo »

antonvs wrote: post #69
snowwrestler wrote: post #65

Earlier quoted context omitted.

You’re not going to find a reliable “debunking” in HN comments of a scientific paper published in Cell. But this paper is about analyzing tissue samples from internal organs. Which is generally not what people feel when they “feel” aging. In fact most internal organs can’t be felt at all (no nerve endings), which is how people get surprised with Stage IV cancer diagnoses like pancreatic cancer. What people generally…

> In fact most internal organs can’t be felt at all (no nerve endings) That might be technically true, but I think it's worth noting that many internal organs can produce pain, e.g. kidneys, gallbladder, pancreas, prostate, urethra, stomach, intestines, bladder, heart.

We get plenty of sensations from our internal organs; just ask anyone who had kidney stones. The sensations may or may not feel like pain, but the internal organs are definitely not silent. The issue of referred pain is mostly related to organs sharing nerve supply at the spinal level, e.g., the liver and the left shoulder.

Re: Ageing accelerates around age 50 ― some organs faster than others

#134

Post by drgo »

I think this study adds to growing evidence that aging doesn’t progress linearly. There’s less evidence supporting a specific inflection point for aging. If aging is like any other biological process, it’s likely to vary a lot between individuals depending on genetic, lifestyle and environmental factors and within an individual between different tissues. Until we develop accurate measures of tissue aging, there’s much we can do other than live as well as we can and as hard as possible.

Re: Ageing accelerates around age 50 ― some organs faster than others

#135

Post by NoOn3 »

hyperman1 wrote: post #13
NoOn3 wrote: post #11

Earlier quoted context omitted.

Maybe. But why in this case do we not see bugs and failures in this program, i.e. no one lived 5 times more than the average or did not live forever at all, for example? I'm not making a statement, just a guess.

You could say this woman is immortal. Or at least her cancer is. https://en.m.wikipedia.org/wiki/Henrietta_Lacks

I'm not a biologist. But it seems to me that this is at the level of one cell. Yes, a cell can become immortal, but cells live much less than a whole person. Over the course of a person's life, many many cells change. And the program for human life, rather than individual cells, is perceived differently.

Re: Ageing accelerates around age 50 ― some organs faster than others

#136

Post by potamic »

wonderwonder wrote: post #66
Mistletoe wrote: post #58

Earlier quoted context omitted.

Can you give more details about what you did?

First thing I did was just get out of the house and go to the gym. I work remotely, it became a trap where I spent all my free time sitting in front of the computer. Prioritizing at least an hour a day 5x a week was huge. I just made the time. I did that for about 2 years with good results. I was 240lbs. I looked big at 6’1 but had lots of fat. I snored all night long, affecting my wife’s sleep as well. About 1 year…

How long do you intend to be on trt? I hear the body returns back to its previous low levels on stopping.

Re: Ageing accelerates around age 50 ― some organs faster than others

#137

Post by Lyngbakr »

bob_theslob646 wrote: post #122
Lyngbakr wrote: post #74

Earlier quoted context omitted.

> And the truth is, there is a lot a person can do to adjust or mitigate these things, through simple lifestyle changes like diet and exercise. This is spot on. I'm 46 and I've been fortunate to be healthy and in decent shape my entire life; however, a check up that was fine but trending in the wrong direction prompted these lifestyle changes. I lift run or lift daily, have reduced my carb intake significantly, stopp…

Why did you reduce your carb intake?

To lose weight. I was at the cusp of being overweight, so decide to get my BMI (an admittedly flawed, but still useful metric) firmly into the middle of the expected range rather than at the upper bound.

Re: Ageing accelerates around age 50 ― some organs faster than others

#138

Post by Lyngbakr »

boppo1 wrote: post #125
Lyngbakr wrote: post #74

Earlier quoted context omitted.

> And the truth is, there is a lot a person can do to adjust or mitigate these things, through simple lifestyle changes like diet and exercise. This is spot on. I'm 46 and I've been fortunate to be healthy and in decent shape my entire life; however, a check up that was fine but trending in the wrong direction prompted these lifestyle changes. I lift run or lift daily, have reduced my carb intake significantly, stopp…

Say more about carb intake and cushion time. What % of calories?

I can't put a number on that, unfortunately. I don't do well with diets that require I keep track of all the details — it feels like a chore and I tend to give up — so I decided instead to adopt a simple rule of thumb: avoid carbs where possible. In practice, this means no breads, no pasta, no doughnuts, no sugary foods, etc. Instead, I eat more protein. This works well for me and I lost 15-20 lbs quite quickly and I now maintain a good weight. YMMV, though.

As for cushion time, my practice is very basic: just 10 minutes of mindfulness meditation each day (usually after working out). I feel calmer, less irritable, and more present in everyday life. It's not a panacea, but I find it helps me.

Re: Ageing accelerates around age 50 ― some organs faster than others

#139

Post by csallen »

dotancohen wrote: post #131
csallen wrote: post #39

Earlier quoted context omitted.

Lots of models could explain this. For example, let's say it's not just one program, but thousand of programs running in your body, trying to get you to age or die. The chances that all of them bug out would be astronomically low.

But there have been astronomically high qualities of humans produced, none of which have shown this phenomenon.

Combinatorics can make things astronomically unlikely.

Imagine the "aging program" bugs out 1 in 100 times, a pretty high failure rate. However, imagine the program runs in 10 systems in the body, and success in any one of these systems is enough to age and kill you. The body is quite fragile after all.

If this were the case, then in order to not age at all, a person would need not just a 1/100 event to occur, but a (1/100)^10 event to occur. That's 1 in 100,000,000,000,000,000,000. In other words, one in a hundred quintillion.

A hundred quintillion is about 840 million times higher than the number of humans who have ever lived, which is 120 billion.

Re: Ageing accelerates around age 50 ― some organs faster than others

#140

Post by HSO »

senectus1 wrote: post #126
kelnos wrote: post #94

Earlier quoted context omitted.

Well, shit, I just turned 44 a few weeks ago. Great, that's what I have to look forward to this year...

I turn 51 this year. I am also in denial. its not just a wet place in egypt.

> its not just a wet place in egypt.

Ill be honest, that one took a few secs for me to get it ("whut??") :)))

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