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Ageing accelerates around age 50 ― some organs faster than others

nature.com

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Re: Ageing accelerates around age 50 ― some organs faster than others

#61

Post by contingencies »

wonderwonder wrote: post #26
zemvpferreira wrote: post #24

Earlier quoted context omitted.

Have you happened upon Keith Barr’s work on tendon repair? Up to a few years ago tendon injuries were thought to be mostly unfixable (you could strengthen what was left of an injured tendon at best) but Barr’s work is proving otherwise. And using a very low risk isometric exercise protocol. It won’t make you feel 32 again but it might help you get rid of a lot of lingering aches and pains.

I combined vitamin C with a daily dose of collagen and it did wonders for my tendons when combined with stretching exercises. My Achilles went from constant pain and at least a couple hours every morning of hobble walking to no pain and just feeling like normal. The doctor recommended surgery and even then made no promises. I still can't run for any real distance but the quality of life difference of just being able…

Glad you found some relief. But take note everyone! Running is probably not that good for you if you plan to live longer than average-lifespan-in-the-past! Cycling, swimming, walking are all low on joint damage. Running isn't.

Re: Ageing accelerates around age 50 ― some organs faster than others

#62

Post by worldsayshi »

bilsbie wrote: post #48
wonderwonder wrote: post #12

I felt incredibly old from ~36 - 42. Then I started seriously working out, took control of my diet (it had very much always controlled me) and started aggressively pursuing a "better living through chemistry" approach to life. I feel 25 years younger now. My BP and cholesterol are under control and I roll out of bed actually feeling rested (probably due to not snoring anymore).

I had a similar experience. It really felt like my body became way more sensitive to my diet in my 40s. I feel great when I eat clean.

I think there's a bunch of anecdata telling that once you start going with a healthier diet you tend to react strongly to eating less healthy food or alcohol.

Re: Ageing accelerates around age 50 ― some organs faster than others

#63

Post by antonvs »

mellosouls wrote: post #49

I've only opened these comments in the hope somebody here will debunk these findings or at least point out they are dubious... :(

I mean, I'm 61, working at a smallish SaaS company that "just growed" from a startup, having fun. I write code, which is the work I enjoy most, I do architecture and explain to the kids why we're doing what we're doing. My health is fine, but I exercise regularly and eat reasonably healthy.

Re my health, I kinda feel like Mad Magazine's Alfred E. Neuman: "What, me worry?" I worry more about the state of the US than I do about my own health. We're all going to die - I've lived a lot longer than many people. I've outlived Steve Jobs by 5 years at this point. Suck it, Steve! (And Jim Morrison? 34 years. Looooser!)

If you do cardio - even just walking/hiking - and weight training, you're going to be healther than 95% of people, and live longer with better quality of life. It's not that difficult.

As you age, if you're reasonably sane, you start letting go of the idea that you can or should live forever.

Re: Ageing accelerates around age 50 ― some organs faster than others

#64

Post by PaulHoule »

pinkmuffinere wrote: post #54
Qem wrote: post #32

Earlier quoted context omitted.

Perhaps not a phase-out program, but a progressive shut-down program, as a trade off between peak performance and total lifespan, where the characteristic patterns of ageing is what allowed humans to live much longer than other animals around the same size. Similar to the idea in this comic: https://www.badspacecomics.com/post/the-suit By this logic, as a hedge against sudden death around ~50, the human body start cr…

I think this argument only makes sense on the surface level. If it was the case that humans hit some hard limit to growth (perhaps running out of 'room' to grow, or losing the ability to process new energy, etc), then I think it could make sense to do this sort of 'graceful decommissioning' behavior, which we'd come to know as aging. But is there a hard limit we hit, aside from the aging process itself? None is obvio…

It's commonly thought that if your cells kept dividing the way that they do when you're young and they accumulated genetic damages you'd get cancer more often.

Re: Ageing accelerates around age 50 ― some organs faster than others

#65

Post by snowwrestler »

mellosouls wrote: post #49

I've only opened these comments in the hope somebody here will debunk these findings or at least point out they are dubious... :(

You’re not going to find a reliable “debunking” in HN comments of a scientific paper published in Cell.

But this paper is about analyzing tissue samples from internal organs. Which is generally not what people feel when they “feel” aging. In fact most internal organs can’t be felt at all (no nerve endings), which is how people get surprised with Stage IV cancer diagnoses like pancreatic cancer.

What people generally feel are their muscles and joints are weaker and more painful. Or their eyesight gets worse. Or their digestive system works worse. And the truth is, there is a lot a person can do to adjust or mitigate these things, through simple lifestyle changes like diet and exercise.

So there is your ray of hope: you can do things differently to feel less old. Plenty of examples in the comments here.

That said, you are 100% for sure going to age and die, and there are also things you can do to help accept and prepare for that. Your body will change; your mind can change too.

Re: Ageing accelerates around age 50 ― some organs faster than others

#66

Post by wonderwonder »

Mistletoe wrote: post #58
wonderwonder wrote: post #12

I felt incredibly old from ~36 - 42. Then I started seriously working out, took control of my diet (it had very much always controlled me) and started aggressively pursuing a "better living through chemistry" approach to life. I feel 25 years younger now. My BP and cholesterol are under control and I roll out of bed actually feeling rested (probably due to not snoring anymore).

Can you give more details about what you did?

First thing I did was just get out of the house and go to the gym. I work remotely, it became a trap where I spent all my free time sitting in front of the computer. Prioritizing at least an hour a day 5x a week was huge. I just made the time.

I did that for about 2 years with good results. I was 240lbs. I looked big at 6’1 but had lots of fat. I snored all night long, affecting my wife’s sleep as well. About 1 year in I got on trt. Huge changes as far as energy levels, sex drive and confidence. Numbers soared at the gym but I was still 240lbs. Still stress eating after 8pm, easily 1200 calories in sugar a night.

In January I got on Glp-1 and am now 209lbs at 46 years old with a 405lb bench. I just stopped eating after 6pm on it. Weight came pouring off. I never experienced any of the side effects people mention. I can eat a whole large pizza if I want without issues, i just don’t.

I’ve since upped the testosterone im on so one can fairly say im on steroids (i am) plus I am an aggressive user of various peptides. I get my blood work done at regular intervals and feel good.

I just decided to take control of my body and do what works for me and not worry about what the medical establishment tells me to do but to do it with proper insight via regular blood tests.

Just got back from a family vacation and after the pool one day my wife asked if I knew that everyone stared at me when I walk past. Felt good. Funny thing is that at 6’1, 209lbs im not that big, im just lean whereas most people are overweight.

I don’t recommend my regime to anyone i just recommend throwing away preconceived notions of what you can and shouldn’t do and to get after being the you that you are proud of.

Re: Ageing accelerates around age 50 ― some organs faster than others

#67

Post by munksbeer »

wonderwonder wrote: post #12

I felt incredibly old from ~36 - 42. Then I started seriously working out, took control of my diet (it had very much always controlled me) and started aggressively pursuing a "better living through chemistry" approach to life. I feel 25 years younger now. My BP and cholesterol are under control and I roll out of bed actually feeling rested (probably due to not snoring anymore).

How did you get the snoring under control?

Re: Ageing accelerates around age 50 ― some organs faster than others

#68

Post by wonderwonder »

munksbeer wrote: post #67
wonderwonder wrote: post #12

I felt incredibly old from ~36 - 42. Then I started seriously working out, took control of my diet (it had very much always controlled me) and started aggressively pursuing a "better living through chemistry" approach to life. I feel 25 years younger now. My BP and cholesterol are under control and I roll out of bed actually feeling rested (probably due to not snoring anymore).

How did you get the snoring under control?

I lost 30lbs. Gone, I sleep like a baby and more importantly so does my wife

Re: Ageing accelerates around age 50 ― some organs faster than others

#69

Post by antonvs »

snowwrestler wrote: post #65
mellosouls wrote: post #49

I've only opened these comments in the hope somebody here will debunk these findings or at least point out they are dubious... :(

You’re not going to find a reliable “debunking” in HN comments of a scientific paper published in Cell. But this paper is about analyzing tissue samples from internal organs. Which is generally not what people feel when they “feel” aging. In fact most internal organs can’t be felt at all (no nerve endings), which is how people get surprised with Stage IV cancer diagnoses like pancreatic cancer. What people generally…

> In fact most internal organs can’t be felt at all (no nerve endings)

That might be technically true, but I think it's worth noting that many internal organs can produce pain, e.g. kidneys, gallbladder, pancreas, prostate, urethra, stomach, intestines, bladder, heart.

Re: Ageing accelerates around age 50 ― some organs faster than others

#70

Post by blargey »

kkoncevicius wrote: post #31
NoOn3 wrote: post #11

Earlier quoted context omitted.

Maybe. But why in this case do we not see bugs and failures in this program, i.e. no one lived 5 times more than the average or did not live forever at all, for example? I'm not making a statement, just a guess.

Such arguments go both ways. For example, if aging is accumulation of damage and not programmed, then why don't we see lucky people who live 5 times longer. Also how come the patterns of aging are so similar between individuals and even between different species (wrinkly skin, grey hair, fragile bones).

How do you propose someone would "luck out of" the wear and tear your body undergoes just to function? It's accumulation of damage to the very systems that work to prevent and repair damage, leading all organs to accumulate the damage they would have hidden by fast repair in "youth". It's unavoidable and accelerating by definition, and that reflects what we observe in aging.

The "patterns of aging" you describe are, again, definitionally just what happens when the same organs built and functioning the same way across species undergo their respective failure modes. It makes more sense for all skins to exhibit the same signs of aging if they're all just wearing out the way "skin" does, rather than being attacked by species-specific "age limiter" processes artificially enforcing lifespan limits. Why would something like skin even need to decay at all, when it's basically unrelated to aging-related death?

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