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The first non-opoid painkiller

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Re: The first non-opoid painkiller

#131

Post by croemer »

gorjusborg wrote: post #34
Snoozus wrote: post #5

This is clickbait, there are at least two classes of non opioid painkillers in use since a long time. https://en.wikipedia.org/wiki/Analgesic

I don't feel the title is misleading, but it may be a cultural language difference. The term 'painkiller' is reserved for strong pain relief, and wouldn't include things like ibuprofen. That made me think immediately of a non-opioid pain blocker not just a pain reliever.

All dictionaries I've looked at (MW, OED, Cambridge) define painkiller broadly as any drug that relieves pain. Do you have a source for your claim that it's used narrowly? Here's mine: https://www.merriam-webster.com/dictionary/painkiller

Re: The first non-opoid painkiller

#132

Post by hn_throw2025 »

4gotunameagain wrote: post #70
ggm wrote: post #2

Colloquially acetaminophen/paracetamol and ibuprofen are "painkillers" but this is in a different class, it's amazing to have something which performs like the opioid pain relief but without at least some of the side effects. It's the first non opioid painkiller applicable for situations like post operative use. I'd have loved this after my hernia op, the last thing you need with that is opioid induced constipation.

What kind of hernia ? In the US it seems like they prescribe opioids like candy. I've never heard of opioids post hernia surgery in Europe.

I had open surgery for an inguinal hernia here in the UK. Was sent home with a box of Codeine, 15mg tablets, to go with the Paracetamol.

Plus some sachets of laxative for any constipation.

Re: The first non-opoid painkiller

#133

Post by colaco »

ocrow wrote: post #121
hallway_monitor wrote: post #102

Earlier quoted context omitted.

I avoid it at all costs because of the possibility of liver damage. Ibuprofen seems to have the same effect without potentially serious side effects.

The drawback of Ibuprofen is that it tends to cause damage to stomach and intestinal linings. That's why you are advised to take with food and/or lots of water. You don't want it absorbing all in one place. Long term use exacerbates the effect, making it more likely to cause ulcers and eventually internal bleeding. My partner ended up in the hospital with a serious internal bleed caused by taking Ibuprofen daily for…

And also kidney failure in prolonged use, usually in patients with any sort of previous kidney damage.

Re: The first non-opoid painkiller

#134

Post by qart »

hallway_monitor wrote: post #102
bigfudge wrote: post #100

Earlier quoted context omitted.

You don't need to take that much. LD50 is surprisingly close to the normal dose, and possible to do if you don't realise that cold remedies contain it (or that aminocetophen and paracetamol are the same thing!)

I avoid it at all costs because of the possibility of liver damage. Ibuprofen seems to have the same effect without potentially serious side effects.

https://x.com/theliverdr/status/1908363713771425946

Again and again, this hepatologist makes his message clear: "Acetaminophen (Paracetamol) is the safest anti-fever and anti-pain medicine even among patients with liver disease. It is the first choice for fever and pain management even in advanced cirrhosis."

Look for some of his other posts on the topic for studies and citations.

Re: The first non-opoid painkiller

#135

Post by hn_throw2025 »

Spivak wrote: post #125
lopis wrote: post #69

Earlier quoted context omitted.

Gabapentin is an anticonvulsants. Ibuprofen and paracetamol are anti-inflammatory. While they are effective at reducing pain, they are technically not "pain killers". The title is therefore correct.

Is that true? That ibuprofen is only reducing my pain via reduced inflammation? I'm sure I've taken it for pain that isn't caused by inflammation.

Yes, but the parent isn't accurate about Paracetamol. It's not anti-inflammatory.

You can take them together within the stipulated limits for each, as one will reduce inflammation and the other will reduce the perception of pain.

Just have to be careful with the stomach when it comes to Ibuprofen... perhaps eat first.

Re: The first non-opoid painkiller

#136

Post by Marazan »

theoreticalmal wrote: post #82
billforsternz wrote: post #40

Earlier quoted context omitted.

Off topic complaint: I am guessing an absolutely massive amount of (admittedly minor in each instance) grief has been caused by the most widely deployed simple, inexpensive, useful and familiar drug unnecessarily having two different names acetaminophen / paracetamol. Finally figured this out this year (aged 64) after previously being confused why I couldn't find any damn paracetamol in pharmacies on my occasional vi…

My wife and I got colds while vacationing in Edinburgh and had a heck of a time before realizing to ask for paracetamol rather than acetaminophen. Also, the rules the UK has for limiting paracetamol purchases to small amount per day are so fantastically stupid.

As annoying as it is (and I agree it is fantastically annoying) much to my surprise admissions for paracetamol overdose to UK hospitals absolutely plummeted after purchasing restrictions were introduced.

Score one for the nanny state.

Re: The first non-opoid painkiller

#137

Post by sigzero »

closewith wrote: post #86
billforsternz wrote: post #40

Earlier quoted context omitted.

Off topic complaint: I am guessing an absolutely massive amount of (admittedly minor in each instance) grief has been caused by the most widely deployed simple, inexpensive, useful and familiar drug unnecessarily having two different names acetaminophen / paracetamol. Finally figured this out this year (aged 64) after previously being confused why I couldn't find any damn paracetamol in pharmacies on my occasional vi…

Paracetamol is the standard and WHO approved name used everywhere except certain parts of the US. It's ridiculous the FDA chose acetaminophen.

I've live for all my life in a lot of places in the US and "Paracetamol" was never used. I'd never heard that term until this HN thread.

Re: The first non-opoid painkiller

#138

Post by delusional »

dspillett wrote: post #108
theoreticalmal wrote: post #82

Earlier quoted context omitted.

My wife and I got colds while vacationing in Edinburgh and had a heck of a time before realizing to ask for paracetamol rather than acetaminophen. Also, the rules the UK has for limiting paracetamol purchases to small amount per day are so fantastically stupid.

> the rules the UK has for limiting paracetamol purchases to small amount per day are so fantastically stupid Worse than that: it is effectively per day per shop. In a very short space of time I can buy two packs in Boots, two in Tesco, two in Sainsbury, ooh look another small Tesco I'll get two there as well, two from Savers, two from SuperDrug, …

Worse in what ways? I think it's a pretty neat feature of the design. If you just need some, you don't get a lot, and you don't get to buy a lot "just in case". If you truly need a lot, you can go though the hassle of going to multiple stores.

It's essentially just raising a barrier for (under normal circumstances) undesirable behavior.

Re: The first non-opoid painkiller

#139

Post by hinkley »

No. Not even the 100th.

Wikipedia:

> At least 100 distinct phytocannabinoids have been isolated from cannabis, although only four (i.e., THCA, CBDA, CBCA and their common precursor CBGA) have been demonstrated to have a biogenetic origin.[6] It was reported in 2020 that phytocannabinoids can be found in other plants such as rhododendron, licorice and liverwort,[7] and earlier in Echinacea.

Cannibinoid receptors are separate from opioid receptors.

Re: The first non-opoid painkiller

#140

Post by closewith »

sigzero wrote: post #137
closewith wrote: post #86

Earlier quoted context omitted.

Paracetamol is the standard and WHO approved name used everywhere except certain parts of the US. It's ridiculous the FDA chose acetaminophen.

I've live for all my life in a lot of places in the US and "Paracetamol" was never used. I'd never heard that term until this HN thread.

The overseas territories are split on which variant they use.
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