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The first non-opoid painkiller

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Re: The first non-opoid painkiller

#81

Post by privatelypublic »

billforsternz wrote: post #40
ggm wrote: post #2

Colloquially acetaminophen/paracetamol and ibuprofen are "painkillers" but this is in a different class, it's amazing to have something which performs like the opioid pain relief but without at least some of the side effects. It's the first non opioid painkiller applicable for situations like post operative use. I'd have loved this after my hernia op, the last thing you need with that is opioid induced constipation.

Off topic complaint: I am guessing an absolutely massive amount of (admittedly minor in each instance) grief has been caused by the most widely deployed simple, inexpensive, useful and familiar drug unnecessarily having two different names acetaminophen / paracetamol. Finally figured this out this year (aged 64) after previously being confused why I couldn't find any damn paracetamol in pharmacies on my occasional vi…

Don't forget people like to call it APAP too.

Re: The first non-opoid painkiller

#82

Post by theoreticalmal »

billforsternz wrote: post #40
ggm wrote: post #2

Colloquially acetaminophen/paracetamol and ibuprofen are "painkillers" but this is in a different class, it's amazing to have something which performs like the opioid pain relief but without at least some of the side effects. It's the first non opioid painkiller applicable for situations like post operative use. I'd have loved this after my hernia op, the last thing you need with that is opioid induced constipation.

Off topic complaint: I am guessing an absolutely massive amount of (admittedly minor in each instance) grief has been caused by the most widely deployed simple, inexpensive, useful and familiar drug unnecessarily having two different names acetaminophen / paracetamol. Finally figured this out this year (aged 64) after previously being confused why I couldn't find any damn paracetamol in pharmacies on my occasional vi…

My wife and I got colds while vacationing in Edinburgh and had a heck of a time before realizing to ask for paracetamol rather than acetaminophen. Also, the rules the UK has for limiting paracetamol purchases to small amount per day are so fantastically stupid.

Re: The first non-opoid painkiller

#83

Post by closewith »

theoreticalmal wrote: post #82
billforsternz wrote: post #40

Earlier quoted context omitted.

Off topic complaint: I am guessing an absolutely massive amount of (admittedly minor in each instance) grief has been caused by the most widely deployed simple, inexpensive, useful and familiar drug unnecessarily having two different names acetaminophen / paracetamol. Finally figured this out this year (aged 64) after previously being confused why I couldn't find any damn paracetamol in pharmacies on my occasional vi…

My wife and I got colds while vacationing in Edinburgh and had a heck of a time before realizing to ask for paracetamol rather than acetaminophen. Also, the rules the UK has for limiting paracetamol purchases to small amount per day are so fantastically stupid.

> Also, the rules the UK has for limiting paracetamol purchases to small amount per day are so fantastically stupid.

Yes, but:

> Responsible for 56,000 emergency department visits and 2600 hospitalizations, acetaminophen poisoning causes 500 deaths annually in the United States. Notably, around 50% of these poisonings are unintentional, often resulting from patients misinterpreting dosing instructions or unknowingly consuming multiple acetaminophen-containing products.

Source: https://www.ncbi.nlm.nih.gov/books/NBK441917/#:~:text=Acetam...

Re: The first non-opoid painkiller

#84

Post by EasyMark »

perching_aix wrote: post #38

> Another example involves nerve growth factor inhibitors like tanezumab. Although tanezumab alleviated inflammatory pain from conditions like osteoarthritis, Phase III trials revealed an unfortunate side effect: rapidly progressive osteoarthritis. Researchers hypothesized that because patients felt so much better, they overused their arthritic joints, accelerating damage. Although further trials were conducted at lo…

maybe they could lower the dosage in future studies? I'm sure they've considered that though and will take it into account.

Re: The first non-opoid painkiller

#85

Post by EasyMark »

OJFord wrote: post #9

I think a better title here than: > The first non-opoid [sic] painkiller might be: > The first non-opioid nociceptive pain-killer Nociceptive pain being that by actual damage to tissue, as opposed to neuropathic pain like a headache or inflammation that you might take a (non-opioid!) NSAID for. https://www.iasp-pain.org/resources/terminology/

I guess that would make sense in a scientific paper or journal, but most people would have no idea what that means and just make for a confusing title that would turn people off from reading it. Almost everyone has heard of opiates in the evening news or social media.

Re: The first non-opoid painkiller

#86

Post by closewith »

billforsternz wrote: post #40
ggm wrote: post #2

Colloquially acetaminophen/paracetamol and ibuprofen are "painkillers" but this is in a different class, it's amazing to have something which performs like the opioid pain relief but without at least some of the side effects. It's the first non opioid painkiller applicable for situations like post operative use. I'd have loved this after my hernia op, the last thing you need with that is opioid induced constipation.

Off topic complaint: I am guessing an absolutely massive amount of (admittedly minor in each instance) grief has been caused by the most widely deployed simple, inexpensive, useful and familiar drug unnecessarily having two different names acetaminophen / paracetamol. Finally figured this out this year (aged 64) after previously being confused why I couldn't find any damn paracetamol in pharmacies on my occasional vi…

Paracetamol is the standard and WHO approved name used everywhere except certain parts of the US. It's ridiculous the FDA chose acetaminophen.

Re: The first non-opoid painkiller

#87

Post by stavros »

theoreticalmal wrote: post #82
billforsternz wrote: post #40

Earlier quoted context omitted.

Off topic complaint: I am guessing an absolutely massive amount of (admittedly minor in each instance) grief has been caused by the most widely deployed simple, inexpensive, useful and familiar drug unnecessarily having two different names acetaminophen / paracetamol. Finally figured this out this year (aged 64) after previously being confused why I couldn't find any damn paracetamol in pharmacies on my occasional vi…

My wife and I got colds while vacationing in Edinburgh and had a heck of a time before realizing to ask for paracetamol rather than acetaminophen. Also, the rules the UK has for limiting paracetamol purchases to small amount per day are so fantastically stupid.

True, but paracetamol overdoses are not a fun death. Granted, you need to take a massive amount, but still.

Re: The first non-opoid painkiller

#88

Post by wtcactus »

rob74 wrote: post #53
ggm wrote: post #2

Colloquially acetaminophen/paracetamol and ibuprofen are "painkillers" but this is in a different class, it's amazing to have something which performs like the opioid pain relief but without at least some of the side effects. It's the first non opioid painkiller applicable for situations like post operative use. I'd have loved this after my hernia op, the last thing you need with that is opioid induced constipation.

I would certainly consider ibuprofen a "painkiller", it works wonders when I get a headache. So the phrase "the first non-opioid pain reliever suitable for treating post-surgery pain" used later in the article should actually have been the title IMHO...

Interesting that for me ibuprofen doesn’t do absolutely anything (and I’m someone that avoided painkillers almost all my life) I take 1g pills and nothing.

Well, not nothing, my stomach clearly doesn’t like it and I feel it.

Human pain and painkillers response seems extremely variable across different subjects.

Re: The first non-opoid painkiller

#89

Post by johnisgood »

4gotunameagain wrote: post #70
ggm wrote: post #2

Colloquially acetaminophen/paracetamol and ibuprofen are "painkillers" but this is in a different class, it's amazing to have something which performs like the opioid pain relief but without at least some of the side effects. It's the first non opioid painkiller applicable for situations like post operative use. I'd have loved this after my hernia op, the last thing you need with that is opioid induced constipation.

What kind of hernia ? In the US it seems like they prescribe opioids like candy. I've never heard of opioids post hernia surgery in Europe.

In Europe they almost never give you opioids. :|

Re: The first non-opoid painkiller

#90

Post by EasyMark »

Snoozus wrote: post #5

This is clickbait, there are at least two classes of non opioid painkillers in use since a long time. https://en.wikipedia.org/wiki/Analgesic

It might be clickbait, but it's also pretty big news of a fairly universal topic and not in the vein of "This one secret that your doctor doesn't want to know!"
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