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Sleep apnea pill shows striking success in large clinical trial

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Re: Sleep apnea pill shows striking success in large clinical trial

#131

Post by garyclarke27 »

bryanlarsen wrote: post #65
BurningFrog wrote: post #34

Earlier quoted context omitted.

I've been using CPAP for 10 years, and it's pretty much the best thing that ever happened to me! The morning after my first real sleep in ~5 years was an unreal improvement. It felt like I was snatched from my death bed and back to normal. I use the nostril mask, and it doesn't really bother me. The full face mask experience is a lot worse. PS Technically, it blows!

I started with full face -- I thought I needed to because I was a mouth breather at night. But with the nostril mask I breathe through my nose.

I tape my mouth shut and use the CPAP nostril mask, work great, I wake fully refreshed.

Re: Sleep apnea pill shows striking success in large clinical trial

#132

Post by D-Coder »

aziaziazi wrote: post #46
bryanlarsen wrote: post #21

Earlier quoted context omitted.

My CPAP provides 3 massive life changing benefits: - a proper night's sleep - moisture that ensures I don't wake up with a massive sinus headache that destroys my morning - letting my partner have a proper night's sleep Any one of the 3 would be worth the minor inconveniences of a CPAP.

> letting my partner have a proper night's sleep I’m interested in this: how’s the CPAP noise perceived by the partners? I don’t snore and usually wake up quickly when doing the "apnea noise", stopping before waking her up. In the meantime I read that CPAP produce a a constant sound + an inconstant sound from the air coming in and out. She needs quietness to sleep and disturbing her sleep refrained me to try it out.…

My partners prefer it to my not-breathing for 30 seconds or more, then gasping for air.

Re: Sleep apnea pill shows striking success in large clinical trial

#133

Post by ProllyInfamous »

mmmBacon wrote: post #112

I would love to try this. I couldn’t tolerate CPAP. I used a dental appliance and that worked really well for a while, although was not perfect. I’m now on a path to have jaw surgery to move my lower and upper jaw by 1cm. I’ve started with extensive orthodontic treatment and it’s super uncomfortable. The thought of the surgery is also fairly terrifying. So if there’s a pill that could help, I’d sign up in about a mil…

>I’m now on a path to have jaw surgery to move my lower and upper jaw by 1cm.

Please don't do this. See my other comment for more suggestions, but try losing weight and/or sleeping with body pillows [i.e. on your side] before you go mutilating your jaw.

>I used a dental appliance and that worked really well

Same — perhaps you need it to be thicker (i.e. spread your jaw just a bit more).

Re: Sleep apnea pill shows striking success in large clinical trial

#134

Post by genocidicbunny »

gertop wrote: post #60
elric wrote: post #14

Earlier quoted context omitted.

> also on my relationship with my partner That's not really much of an issue. There's an adjustment period, and there's a bit of an art to finding an appropriate mask. One that fits perfectly fine for you might have an exhaust port that blows air in your partner's face. Or the one that your partner can't hear at all might sound thunderously loud in your ears. But all in all, your partner would much rather have you sl…

> That's not really much of an issue. Yes yes love conquers everything and whatnot. Doesn't change the fact that some people need absolute silence to fall asleep and a CPAP machine is very disturbing to them. So they have to sleep with earplugs which, again, is an issue for other reasons. Please don't generalize your own experience with your partner onto all of us.

Or alternatively, they need the noise, but cannot tolerate rhythmic noise. A CPAP machine to me isn't disturbing because of the noise -- if anything I would prefer some noise to drown out the mild tinnitus. It would be disturbing because it would be a fairly repetitive noise, and my brain would very quickly lock onto it and not allow itself to relax and let me sleep. Even a lot of 'random noise' videos on youtube end up being repetitive enough to trigger this.

I had a friend stay with me for a week or so, and they use a CPAP machine. Due to the poor sound insulation in the house, I could hear the machine from the guest bedroom to mine. It was one of the few times when I had to find some really long-form content on youtube to leave it playing all night on the tv in my bedroom to drown out the repetitiveness of the CPAP machine. For the first few hours of the first night I ended up waking up two or three times an hour because of the repetitive sound of the machine before I realized it.

Re: Sleep apnea pill shows striking success in large clinical trial

#135

Post by morjom »

kimjune01 wrote: post #91

Sleep apnea is a structural issue, either soft or bone. CPAP helps, but it doesn't address the root cause. Fixing it is a matter of airway geometry, with many obstructions along the way. Bodybuilders or wrestlers, otherwise in good health, can suffer from OSA because of too much muscle in their neck. You may not know it, but your tongue may be tied. It is one of many possibilities causing OSA. I made this: Do I have…

Central Sleep Apnea exists aswell.

Re: Sleep apnea pill shows striking success in large clinical trial

#136

Post by felideon »

cjbgkagh wrote: post #113

It is Tirzepatide which is a GLP-1 agonist, like Semaglutide (Ozempic). I don't know how much of the co-occurring issues from sleep apnea are caused by the sleep apnea or are comorbidities for something else. I suspect quite a lot of the later. I think we're going to find that GLP-1 agonists are really good for a lot of things beyond obesity including many auto-immune conditions which I think underlies many mental co…

Hmm? Article says it’s a combination of atomoxetine and aroxybutynin.

Re: Sleep apnea pill shows striking success in large clinical trial

#137

Post by ProllyInfamous »

gosub100 wrote: post #114
N00dlesHead wrote: post #68

I cant use a cpap so anything else worth trying is good for me. I have nocturnal seizures, need a sports guard to keep from biting chunks off my tongue while sleeping, plus a deviated septum. Cpap doesnt work for me theres no air flow,so Im waiting on both surgery on my nose (going on 3 years) and a mouth guard to pull my jaw forward which is taking forever as well. I havent had a decent sleep in years

this won't solve all your problems, but replacing the sports guard with a rubber one that is meant for bruxism, or even better, paying the $400 and getting a custom one from your dentist, will help a lot. the sports guards aren't soft enough to prevent damage to the surface of your teeth. My custom dental guard has lasted for several years, and although I was skeptical at first, the cost was worth it.

>paying the $400 and getting a custom one from your dentist

This was also a very difficult financial decision for me, but like you already said:

>although I was skeptical at first, the cost was worth it.

Re: Sleep apnea pill shows striking success in large clinical trial

#138

Post by lrasinen »

sfink wrote: post #104

One thing that I've found very helpful, and wish my doctor had mentioned: when putting on the CPAP (nasal pillows in my case), time turning it one with your breathing such that the machine first kicks in during an inhale. That's it. It sounds trivial. But my biggest problem[1] with the CPAP is that it feels like it's smothering me. I can get more air in, faster, without the CPAP, and I still vividly remember the init…

My preferred method (Resmed Mirage FX) is to put the mask on, but without the hose connected. Then turn the machine on, wait until I can hear the air whooshing out of the hose and then clip the hose to the mask.

... but also as @elric has said, getting it set up properly is important. The first few weeks it felt restrictive, I complained and the hospital cranked up the initial pressure from 4 units to 6 units, and it's been great ever since.

Re: Sleep apnea pill shows striking success in large clinical trial

#139

Post by cjbgkagh »

felideon wrote: post #136
cjbgkagh wrote: post #113

It is Tirzepatide which is a GLP-1 agonist, like Semaglutide (Ozempic). I don't know how much of the co-occurring issues from sleep apnea are caused by the sleep apnea or are comorbidities for something else. I suspect quite a lot of the later. I think we're going to find that GLP-1 agonists are really good for a lot of things beyond obesity including many auto-immune conditions which I think underlies many mental co…

Hmm? Article says it’s a combination of atomoxetine and aroxybutynin.

Ah, you are correct, for some reason only the later mentioned previously approved drug was retained in memory.

Re: Sleep apnea pill shows striking success in large clinical trial

#140

Post by blarg1 »

ProllyInfamous wrote: post #125

I am a fattie (BMI 36.5). I also have sleep apnea. Wearing a CPAP, I couldn't ever get any sleep (toss&turner). Things that've helped: 1) Using body pillows to force sleeping on side, which straightens the neck (versus face-down) — also lessens low-back pain 2) DENTAL GUARD (a 3D-printed plastic insert which form-fits my teeth, slightly opening jaw-angle/mouth) 3) Losing weight — YES, sleep apnea is worsened by exces…

> 3) Losing weight — YES, sleep apnea is worsened by excess weight

That solved it for me.

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