Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Sleep apnea pill shows striking success in large clinical trial

science.org

Post reply on HN
Print view View original

111–120 of 226 posts

Re: Sleep apnea pill shows striking success in large clinical trial

#111

Post by EA-3167 »

elric wrote: post #7

I swear CPAP wouldn't get such a bad rep if the media would stop using pictures of men with obscenely large full face masks. The most commonly used CPAP mask is probably the minimalist Resmed P10 [1]. It looks a lot less intimidating than a bulky full face mask. And in most cases, full face masks aren't needed (no sources to cite, but titrating to the correct pressure allows most people to breathe through their noses…

These aren't drugs that I'd choose to take when a proven therapy like the use of a CPAP exist, the list of potential serious adverse reactions isn't trivial at all. Most amusingly insomnia is a known risk of atomoxetine.

I understand that this might be a viable option for people who simply cannot tolerate CPAP therapy, have tried alternatives and found them lacking, and aren't surgical candidates... but I certainly hope it never becomes a first line treatment. My concern would also be that insurance companies will see this as a much cheaper option and try to force it on people who would otherwise tolerate CPAP therapy.

Re: Sleep apnea pill shows striking success in large clinical trial

#112

Post by mmmBacon »

I would love to try this. I couldn’t tolerate CPAP. I used a dental appliance and that worked really well for a while, although was not perfect. I’m now on a path to have jaw surgery to move my lower and upper jaw by 1cm. I’ve started with extensive orthodontic treatment and it’s super uncomfortable. The thought of the surgery is also fairly terrifying. So if there’s a pill that could help, I’d sign up in about a millisecond.

Re: Sleep apnea pill shows striking success in large clinical trial

#113

Post by cjbgkagh »

It is Tirzepatide which is a GLP-1 agonist, like Semaglutide (Ozempic). I don't know how much of the co-occurring issues from sleep apnea are caused by the sleep apnea or are comorbidities for something else. I suspect quite a lot of the later. I think we're going to find that GLP-1 agonists are really good for a lot of things beyond obesity including many auto-immune conditions which I think underlies many mental conditions.

Re: Sleep apnea pill shows striking success in large clinical trial

#114

Post by gosub100 »

N00dlesHead wrote: post #68

I cant use a cpap so anything else worth trying is good for me. I have nocturnal seizures, need a sports guard to keep from biting chunks off my tongue while sleeping, plus a deviated septum. Cpap doesnt work for me theres no air flow,so Im waiting on both surgery on my nose (going on 3 years) and a mouth guard to pull my jaw forward which is taking forever as well. I havent had a decent sleep in years

this won't solve all your problems, but replacing the sports guard with a rubber one that is meant for bruxism, or even better, paying the $400 and getting a custom one from your dentist, will help a lot. the sports guards aren't soft enough to prevent damage to the surface of your teeth. My custom dental guard has lasted for several years, and although I was skeptical at first, the cost was worth it.

Re: Sleep apnea pill shows striking success in large clinical trial

#116

Post by petesergeant »

jonmagic wrote: post #107

After nearly 14 years of using a cpap ( https://theprogrammingbutler.com/blog/archives/2014/02/13/sl... ) and then bipap religiously I was able to switch away recently. All I do now is use now is a piece of kinesthetic tape to make sure my mouth stays closed and that somehow works. I’d just done another sleep study to see if I had options other than the bipap because it’s been filling me with air since I was intubate…

A similar fix for me was a nasal steroid taken every night. Got me off the CPAP

Re: Sleep apnea pill shows striking success in large clinical trial

#117

Post by op00to »

balls187 wrote: post #10
elric wrote: post #7

I swear CPAP wouldn't get such a bad rep if the media would stop using pictures of men with obscenely large full face masks. The most commonly used CPAP mask is probably the minimalist Resmed P10 [1]. It looks a lot less intimidating than a bulky full face mask. And in most cases, full face masks aren't needed (no sources to cite, but titrating to the correct pressure allows most people to breathe through their noses…

Do you wear a cpap? It sucks. I have an OA now. And it also sucks.

My cpap mask doesn’t suck at all. It blows. (Wokka wokka!)

But it also makes sleep way more comfortable. I slept the entire night in my mask the first night, I was so worried about it and it turned out to be a non-issue. I love my mask.

Re: Sleep apnea pill shows striking success in large clinical trial

#118

Post by op00to »

aziaziazi wrote: post #46
bryanlarsen wrote: post #21

Earlier quoted context omitted.

My CPAP provides 3 massive life changing benefits: - a proper night's sleep - moisture that ensures I don't wake up with a massive sinus headache that destroys my morning - letting my partner have a proper night's sleep Any one of the 3 would be worth the minor inconveniences of a CPAP.

> letting my partner have a proper night's sleep I’m interested in this: how’s the CPAP noise perceived by the partners? I don’t snore and usually wake up quickly when doing the "apnea noise", stopping before waking her up. In the meantime I read that CPAP produce a a constant sound + an inconstant sound from the air coming in and out. She needs quietness to sleep and disturbing her sleep refrained me to try it out.…

My partner has never heard any “cpap noise”. I just asked.

Re: Sleep apnea pill shows striking success in large clinical trial

#119

Post by leovander »

bagels wrote: post #86
nanipunani wrote: post #81

People using a CPAP - have you looked at Inspire? [1]. My pulmonologist friend highly recommends it. The device has very high success rate and is now in the 5th generation of development. https://www.inspiresleep.com/en-us/

Is it an implanted device? The website makes it really hard to find out how it is worn, or if it is surgically implanted.

Surgically implanted under the collar bone.

https://www.accessdata.fda.gov/cdrh_docs/pdf13/P130008d.pdf

Re: Sleep apnea pill shows striking success in large clinical trial

#120

Post by ianburrell »

rowanseymour wrote: post #64
Citizen8396 wrote: post #63

Earlier quoted context omitted.

You might want to consider an oral appliance. There's no guarantee you will tolerate them or get the desired effect, but the same goes for surgery. Oral surgeries often have dentists who are certified in sleep medicine who can create a custom, medical-grade appliance for you. https://en.wikipedia.org/wiki/Mandibular_advancement_splint

I tried everything I could find on Amazon but obviously that crap doesn't work. I can believe something custom made could help but my orthodontist persuaded me the only really solution was surgery or CPAP.

There are specialized dentists that make appliances. My understanding is custom works much better cause fits perfectly instead of having to mold it. If you can, go to dentist that has experience. They are expensive, mine was $3k.
Post reply on HN