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Sleep apnea pill shows striking success in large clinical trial

science.org

51–60 of 226 posts

Re: Sleep apnea pill shows striking success in large clinical trial

#51
post #15

It's definitely an interesting outcome and nice to see such a significant improvement in a clinical trial. And as the article states, there are questions that aren't addressed - does the reduction in obstructive events change the clinical symptoms such as daytime sleepiness? Intuitively you would think it does, but it should be measured in the trial. I also didn't see anything about adverse events during the trial. S…

Five events is the threshold at which (mild) sleep apnea can be diagnosed.

Re: Sleep apnea pill shows striking success in large clinical trial

#52
post #50
post #19

Or try, no booze, lose a bit of weight, increase cardio activity and sleep on your side. This works pretty well for obstructive but sadly not central apnea.

Any way to discern one from another?

A sleep study. Central and obstructive sleep apnea aren't mutually exclusive, either.

Re: Sleep apnea pill shows striking success in large clinical trial

#53
post #29

Earlier quoted context omitted.

My CPAP does the first two. But generally if you get event the tiniest leak (and it's hard to stop all the leaks) it's very noisy for my partner. My masks leaks so little that I have between 0 and 1 events per hour but it's still annoyingly loud so my partner usually sleeps in our guest bedroom. If I could take a pill instead I would do so gladly. That being said my CPAP machine typically reduces events by 98% or so,…

Luckily my partner likes to sleep with a large fan; the noise of the CPAP blends well with that. But you're right about the leak noise -- about once a month I do get swatted in the middle of the night to adjust my mask.

There are cheap white noise machines that can cover the CPAP noise, without producing wind.

Took me 1-2 nights to be used to it when I tried it.

Re: Sleep apnea pill shows striking success in large clinical trial

#54
I don't have sleep apnea but during allergy season my nose does like to get stuffed at night causing my mouth the get really dry which causes me to wake up a few times.

I've been using nasal strips for the last few weeks and those events have stopped. I swear I also feel better during the day.

Re: Sleep apnea pill shows striking success in large clinical trial

#55
post #19

Or try, no booze, lose a bit of weight, increase cardio activity and sleep on your side. This works pretty well for obstructive but sadly not central apnea.

OSA is not always positional. Further, there are patients with normal BMI who also don't drink.

Re: Sleep apnea pill shows striking success in large clinical trial

#56

I don't have sleep apnea but during allergy season my nose does like to get stuffed at night causing my mouth the get really dry which causes me to wake up a few times. I've been using nasal strips for the last few weeks and those events have stopped. I swear I also feel better during the day.

Fluticasone can be especially helpful for people with allergies and/or OSA.

"Intranasal fluticasone treatment may be useful for patients with nasal obstruction-related obstructive sleep apnea to improve sleep quality and limit daytime dysfunction."

https://pubmed.ncbi.nlm.nih.gov/31521518/

"Intranasal steroids and montelukast did not decrease AHI; however, total sleep time and percent of stage R sleep significantly increased. Self-reported improvement could be explained by observed changes in sleep parameters. Larger prospective studies could help elucidate the effects of medical therapy on adult patients with OSA."

https://pubmed.ncbi.nlm.nih.gov/31383235/

Re: Sleep apnea pill shows striking success in large clinical trial

#57
post #4

I worry about developing sleep apnea, not only for the effects on my health, but also on my relationship with my partner. A medicine that treated sleep apnea would be revolutionary for so many people.

There are already nasal and throat sprays that help. I use throat spray and it helps a lot for getting better sleep for me and wife.

Call me curious. Where do these sprays fall between homeopathy and verifiable?

I used to use a CPAP but now use an approved dental appliance (fancy word for an expensive mouth guard that readjusts your jaw). I would incorporate a spray that actually helps, if only just a little.

Re: Sleep apnea pill shows striking success in large clinical trial

#58
post #11
post #5

Earlier quoted context omitted.

We have numerous good options to deal with high blood pressure, I wouldn't say this is really a problem. Many people take medicine for high blood pressure and live the rest of their lives completely unhampered.

Virtually any pill you have to take for life has negative side effects. Medicine made serious progress in all kind of ways but we don't have magic pills yet, even simple things like fixing a broken bone "only" has a 90-95% success rate without complications. Stay in shape, eat clean an exercise, once it's gone it's gone for good

Many people have high blood pressure in spite of being in the top percentage of health and fitness. It gets tiring seeing people blame it on lack of exercise. Genetics is a thing.

Re: Sleep apnea pill shows striking success in large clinical trial

#59
post #19

Or try, no booze, lose a bit of weight, increase cardio activity and sleep on your side. This works pretty well for obstructive but sadly not central apnea.

While I agree with you and have done this myself, if you're going to make lifestyle change recommendations, at least spell "lose" correctly ;)

I went from ~220 lbs/100 kg to ~160 lbs/ 73 kg. I had to dial back my CPAP over time and eventually switched to a mouth guard which can treat both OSA and TMD.

Re: Sleep apnea pill shows striking success in large clinical trial

#60
post #14
post #4

I worry about developing sleep apnea, not only for the effects on my health, but also on my relationship with my partner. A medicine that treated sleep apnea would be revolutionary for so many people.

> also on my relationship with my partner That's not really much of an issue. There's an adjustment period, and there's a bit of an art to finding an appropriate mask. One that fits perfectly fine for you might have an exhaust port that blows air in your partner's face. Or the one that your partner can't hear at all might sound thunderously loud in your ears. But all in all, your partner would much rather have you sl…

> That's not really much of an issue.

Yes yes love conquers everything and whatnot. Doesn't change the fact that some people need absolute silence to fall asleep and a CPAP machine is very disturbing to them. So they have to sleep with earplugs which, again, is an issue for other reasons.

Please don't generalize your own experience with your partner onto all of us.

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